生性

Breast proliferative fibrocystic change: often caused by endocrine disorders, with intraductal papillary hyperplasia were prone to cancer.

乳腺增生性纤维囊性变：常因内分泌失调引起，伴有导管内乳头状增生者易发生癌变。

Fibrocystic breast disease is an abnormal breast tissue proliferative diseases neither inflammatory nor tumor belong to the RUPI area of the TCM.

乳腺囊性增生症是一种乳腺组织异常增生性疾病，既非炎症，也不是肿瘤，属于中医&乳癖&的范畴。

Methods Nuclear β-catenin expression was detected by immunohistochemistry in 77 lesions with desmoid-type fibromatosis and 171 other spindle cell lesions, including superficial fibrmoatosis (n=18), nodular fasciitis (n=36), keloid (n=16), scar (n=10), granulation tissue (n=9), synovial sarcoma (n=38), neufibroma (n=13), solitary fibrous tumor (n=12), gastrointestinal stromal tumor (n=10), low-grade myxofibrosarcoma (n=3), low-grade fibromyxoid sarcoma (n=3), and smooth muscle tumor (n=10). In addition, the immunohistochemical expressions of ER-α, ER-β and Ki-67 were examined in all of the lesions with desmoid-type fibromatosis. The nuclear immunohistochemical staining for nuclear βcatenin and ER-β was graded as high level (≥25% of cells), low level (5%-25%) or none.

采用免疫组织化学染色法检测77例韧带样型纤维瘤病和171例其它良、恶性梭形细胞病变（包括结节性筋膜炎36例、浅部纤维瘤病11例、瘢痕疙瘩16例、增生性瘢痕10例、肉芽组织9例、滑膜肉瘤38例、神经纤维瘤13例、孤立性纤维性肿瘤12例、胃肠间质肿瘤10例、低度恶性黏液纤维肉瘤3例、低度恶性纤维黏液样肉瘤3例及平滑肌肿瘤10例）组织中β-catenin核阳性的表达，同时检测韧带样型纤维瘤病中ER-α、ER-β和Ki-67的表达。

Connective tissue growth factor may play an important role in promoting the fibrotic process of hypertrophic scar and keloid tissue.

结论结缔组织生长因子在增生性瘢痕和瘢痕疙瘩纤维化进程中可能起着促进作用

Methods1. Twenty-four preretinal fibrovascular membranes were obtained from the patients with PDR during vitrectomy, of them 12 received Avastin intravitreally before surgery and the other 12 did not. Ten preretinal membranes were obtained from patients with proliferative vitreoretinopathy served as controls.

方法1。玻璃体切除术中取出的24例PDR患者的视网膜前新生血管膜，其中术前玻璃体内注射Avastin者12例，未使用Avastin治疗者12例；以10例增生性玻璃体视网膜病变的视网膜前增生膜作为对照。

Add natural disposition, can help advance somebody's career with soil, bush shape, tall 2 ～ 3 meters; The bine is compressed, foliaceous, much more ramose, in costal region is remarkable; Articulatory, do not have thorn glossily; Beautiful sheet is unripe, large body, two side are symmetrical, pure white, have scent, be in about evening 10 when the left and right sides is open, next dies of old age before morning day break.

附生性，能用土壤栽培，灌木状，高2～3米；茎扁平，叶状，多分枝，中肋显著；分节，光滑无刺；花单生，大形，两侧对称，纯白色，有芳香，约在晚间10时左右开放，翌晨天亮前凋谢。

ObjectivesOsteoarthritis of the knee, also named as hyperplasive gonarthritis, or osteoarthrosis of the knee, is a common degenerative articular disease, characterized with pain and stiffness of the knee, and fractional sound when the knee is moving.

一。研究目的膝骨性关节炎(Osteoarthritis of the knee，KOA)，又称增生性膝关节炎、膝骨关节病等，是一种常见的退行性关节疾病，临床上以膝关节疼痛、僵硬、活动受限、活动时可有摩擦响声为特征，是一种累及骨、滑膜及关节周围支持结构的疾病。

Our result showed that P450scc expression was observed in hippocampus, habenular nucleus, neuron nucleus of thalamus and hypothalamus, and cerebral neocortex. The colocalization of P450scc and NeuN demonstrated that most of P450scc exist in neuron cell in these regions. In order to clarify the transcriptional regulation of CYP11A1 gene, established the transient SCC-iCre transgenic mice model by using R26R system to study the promoter activity of human CYP11A1 gene in the brain.

为了证明内生性P450scc在这些脑区的表现，本研究利用免疫组织染色分析，说明了在小鼠海马回结构，间脑内的上视丘疆核、视丘神经核、下视丘神经核，与新皮质等区域中皆可侦测到，且主要表现在神经细胞。

In the present study, biochanin A and hesperitin were shown to activate endogenous CBF1-dependent Notch signaling via both time- and dose-dependent manners.

本论文的研究得知结果显示，biochanin A与hesperitin可活化K562细胞的内生性Notch讯息传导，并且这些活化现象都具有剂量与时间依赖效应。

In the biological functionaddition, both biochanin A and hesperitin might inhibited the colony -formation forming ability of K562 cells through up-regulated Notch signaling. Besides,The treatment with biochanin A and hesperitin enhanced the erythroid-differentiation of K562 cells. It is important to investigate Tthe molecular mechanisms of biochanin A and hesperitin to regulate the endogenous CBF1-dependent Notch signaling will be further investigated.

在生物功能方面，biochanin A与hesperitin可能经由Notch讯息传导的活化，抑制了K562细胞群落的形成，除此之外，这两种药物均明显促进K562细胞往红血球分化。biochanin A与hesperitin对於CBF1所媒介之内生性Notch讯息传导的分子调控机制仍有许多问题尚未厘清，需要更多的实验与研究来讨论。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。