生上皮

Results showed that TDI induced toxic action on spermatogenic cell,while the chondriosome was its target within the length and concentrations.

结果表明：在本实验染毒时间和染毒剂量范围内，TD I对雄性的生殖毒性主要表现为对各级生精细胞均有一定的毒性作用，作用的靶点是细胞内的线粒体；TD I通过影响各种酶的活性，干扰了睾丸组织的有氧代谢和无氧供能，抑制了细胞对能量的利用，损伤了各级生精细胞，导致生精上皮不可逆的损害，从而造成了其对雄性生殖系统的损伤；TD I对雄性生殖细胞的核酸代谢以及DNA合成有一定影响。

In this study, we found that β-catenin, c-JUN, c-myc and GSK3β might be involved in squamous metaplasia of airway epithelium induced by methylcholanthrene, vitamin A deficiency or cigarette smoking by investigating the rat model of squamous metaplasia.

本项目通过维生素A缺乏、吸烟及气管内注入甲基胆蒽复制体外气道上皮鳞化动物模型，发现β-连环素、c-JUN、c-myc 及GSK3β可能介导了甲基胆蒽、VitA 缺乏与吸烟所致的大鼠支气管上皮鳞状化生。

Result of HE and special dye1.1 result of HE More cells are found in subsequent cholesteatoma. Cholesterol crystal, both sequestrum and neogenesis bone , gland metaplasia, Polykaryocyte are found in subepidermis of subsequent cholesteatoma.

结果1、HE染色结果：可见后天性胆脂瘤上皮的细胞层次增多，上皮内及上皮下有不同程度的急性、慢性炎细胞浸涧；上皮下有时可见胆固醇肉芽肿、死骨与新骨形成、腺体化生等病理改变。

Part I Role of glycogen synthase kinase 3 in squamous differentiation induced by cigarette smoke in porcine airway epithelial cell Squamous differentiation of airway epithelium induced by diverse stimuli, such as cigarette smoke, has been thought to be an adaptive response to chronic injury as well as a precancerous lesion of lung squamous carcinoma.

第一部分糖原合成酶激酶3在吸烟诱导的猪气道上皮细胞鳞状分化中的作用研究气道上皮的鳞状细胞化生常见于慢性支气管炎症、致癌剂刺激等，一般被认为是对慢性损伤的一种适应性反应，也是肺鳞癌的癌前病变，其分子机制尚未完全阐明。

A portion of ductal cells and individual serous acinic cells of the minor salivary gland also expressed Fas not only in membranous but also in cytoplasmic pattern.

结果发现，在正常鼻咽粘膜表面及隐窝的假复层纤毛柱状上皮细胞胞膜、部分小涎腺的导管上皮和个别浆液性腺泡上皮细胞的胞膜和胞浆Fas阳性表达；鳞状化生上皮的表层细胞胞膜有Fas表达，但基底细胞未见Fas表达；浸润的淋巴细胞也不表达Fas.45.9%（17/37）的鼻咽非角化性癌Fas阳性，但只有不足10%的癌细胞胞膜微弱表达Fas。

These cancer cells might histogenetically be related to the transitional or metaplastic epithelium of prostate according to morphological analysis,(2) Mucinous adenocarcinoma, Xanthomatous carcinoma, ductal carcinoma, medullary carcinoma, endometrioid carcinoma, papillary carcinoma and signet-ring cell carcinoma were positive for PSA and 35βH11, these carcinomas might histogenetically be related to prostatic secretory epithelium,(3) Prostatic carcinoid showed positive to PSA, 35βH11, NSE and CgA, corresponded with endocrine cell originator,(4) Small cell carcinoma were negative for PSA, 35βH11, NSE and CgA, whether or not it originates from endocrine cells, storage cells or basal cell of prostate had yet to be proved,(5) 34βE12 marking was negative in cancerous areas of 27 cases, and the basal cells were absent in PPTC.

从形态分析，这两种癌可能同源于移行上皮或化生上皮：（2）粘液腺癌、黄色瘤样癌、导管癌、髓样癌、宫内膜样癌、乳头状癌及印戒细胞癌均显PSA及35βH11阳性，提示这几种癌可能来源于分泌上皮，（3）类癌对PSA、35βH11、NSE及CgA均显阳性，符合内分泌细胞来源，（4）小细胞癌无PSA、NSE及CgA表达，对c-erbB-2及35βH11显阳性，是否来源于前列腺内分泌细胞、储备细胞或基细胞有待证实，（5）27例癌区均无34βE12表达，提示PPTC中基细胞缺失。

ResultsIn group C and D hyperplasia of epithelium cell and infiltrations of inflammative cell in day 14 that were severe than that of day 7,ciliate cell was piece loss,the glands were hyperplasia（≥40% of group C,≤20% of group D）in windpipe,and pulmonary alveolus were congestion and dropsy.In group C the epidermis were pucked and connective tissue was hyperplasia in the skin,the quantity of hair ball and the sweat glands of group C and D in the food were significantly reduced than that of group A.

结果第14天时，C组、D组气管上皮鳞状化生，C组气管纤毛多呈片状缺损，而D组多呈灶状缺损；两组气管黏膜炎性细胞浸润均较第7天为重，伴气管浆液腺上皮黏液腺化生（D组≥40%、C组≤20%）、肺泡淤血、水肿。C组皮肤表皮呈不规则皱缩、毛球数明显减少；C组、D组足垫部皮肤表皮增厚、汗腺减少伴结缔组织增生。

This study demonstrated ①the infraglottic mucosa of the 〓 month human fetus iscandidate for culturing human laryngeal epithelial cells;②the cytokeratins of lowmolecular weight could be used as identified marker;③the basal and intermediatecells might possess the ability of bipotential differentiation and the ciliatedepithelium of the 〓 week fetal larynx might be a transitional form of thesquamous metaplasia.

抗低分子量细胞角蛋白抗体可用作细胞鉴定的标志；3.13周以后胎喉声门下粘膜为纤毛上皮，其基底细胞和中间细胞具有双向分化的潜能，在某些条件的刺激下，有可能化生为鳞状上皮细胞。

The results show that the secretory ducts are schizogenous cavity which are only distributed in the stem and the leaf.The initial of the secretory duct drives from the ground meristem.

结果表明，分泌道为裂生腔隙，只分布于茎和叶中；分泌道原始细胞起源于基本分生组织；分泌道原始细胞团裂隙的扩大靠鞘细胞的插入和上皮细胞自身的切向伸长；成熟的分泌道呈圆形或椭圆形，由一层上皮细胞和其外的1 ～2 层鞘细胞包被。

Histologically, the seminiferous tubules contained numerous Sertoli cells and more Sertoli-spermatozoa complexes, accompanied by the depletion of Leydig cells with deeply stained nuclei. Mature spermatozoa were stored up in the epididymis, but only a few in the efferent ducts. In the second place was testicular atrophy（32/120; 26.7%）. The seminiferous tubules showed moderate to severe inactivity of spermiogenesis with evidence of only spermatogonia, spermatocytes and Sertoli cells. The Leydig cells were obviously decreased in numbers associated with decrease of lipid droplets in their cytoplasms. Testicular hypoplasia was the third disorders（22/120; 18.3%）. Only a few spermatogonia and Sertoli cells appeared without any spermiogenesis. The associated changes was decreased in Leydig cells and fibrous hyperplasia in the interstitium.Epididymal stones were sometimes found（12/120; 10%）. Grossly, yellowish-white nodules with various sizes and firm in consistency were observed in the epididymis and the front efferent ducts. Microscopically, the epididymal ducts were dilated with voluminous spermatozoa storage, even showed calcification in severe cases. The deposited calcium salts were stained positively by Von Kossa and Alizarin red methods.Amyloidosis was also detected in 10 roosters（8.3%）. Eosinophilic, homogeneous, amyloid-like substances were deposited mainly in the testicular interstitium and the periphery of blood vessels. These substances showed positive reaction by Congo red staining. Five roosters（4.2%）had Marek's lesions in the testis, epididymis and peripheral nerves with infiltration of pleomorphic lymphocytes. Only one case showed epithelial necrosis of seminiferous tubules accompanied by fibrous proliferation in the interstitium.

结果发现，在总共搜集的120个病例中，其中因年老所导致的产精力不佳为最多，占38例（31.7%），於镜下可见大量精虫黏附於Sertoli cell的表面，并可见Sertoli cell数量明显增多而Leydig cell明显减少，且其细胞核呈现浓染的现象，而在其副睪中仍可见到成熟精虫蓄留於管腔中，但在其输精管内却只有少量精虫存在；其次为睪丸萎缩，占32例（26.7%），镜下可见中度至重度无造精作用，其生精小管中只见到精母细胞、精原细胞及Sertoli cell存在，但Leydig cell数量明显减少且其细胞质内的脂质也明显减少；睪丸发育不全，占22例（18.3%），於生精小管内只见到精母细胞及少量Sertoli cell存在，不见造精细胞分化，於生精小管间质可见Leydig cell减少并伴随结缔组织增生；副睪结石，占12例（10%），肉眼下可在副睪及输精管前段见到黄白色大小不一的结节，触感坚硬，於镜下可见副睪管扩张并有大量成熟精虫蓄积，严重时可见钙化现象，以Von Kossa及茜素红染色均呈阳性反应；类淀粉沉著症，占10例（8.3%），镜下在睪丸间质及血管周围可见粉红均质样的物质沉积，以刚果红染色成阳性反应；马立克病，占5例（4.2%），镜下可在睪丸、副睪实质及周边神经内均可见到嗜碱性大小不一的淋巴样细胞浸润；睪丸坏死，占1例（0.8%），镜下可见生精小管上皮细胞坏死脱落及间质结缔组织增生。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。