甘草酸

Amounts of the glycyrrhizic acid were determined by ultraviolet spectrophotometry at 252 nm wavelengh. Result The best extraction conditions from decoct method were that amount of affusion wate was 200 mL, extract 2 times, boiling time was 5 min, crash time was 20 s.

利用正交试验4因素3水平选择最佳提取条件(包括加水量、提取次数、煮沸时间、粉碎时间、溶剂量、振荡时间、氨水浓度)，用紫外分光光度法在252 nm波长处测定甘草酸含量。

Methods 108 cases with chronic severe hepatitis were randomly divided into treatment group (n=36) treated with compound glycyrrhizin and control group (n=36) treated with diammonium glycyrrhizinate, and compare the curative effect between 2 groups.

将108例慢性重症肝炎患者随机分为治疗组和对照组，治疗组给予复方甘草酸苷，对照组给予甘草酸二铵，比较2组临床治疗疗效。

This effect was observed clearly at final concentration between 1 and 10μ mol/L after treating for 24 hours. We concluded that the possible mechanisms of hydroquinone bleaching hyperpigmented skin were through its inhibition of tyrosinase activity at lower concentration and its cytotoxicity at higher one.

提示18α-甘草酸双胺盐、熊果苷的皮肤脱色作用机制与氢醌可能不同，后者低浓度时以抑制酪酸酶活性为主，高浓度时主要是细胞毒，且细胞早期的损伤部位可能发生在树状突。18α-甘草酸双胺盐能否成为一种无细胞毒酪氨酸酶抑制型皮肤脱色剂有待进一步临床加以验证。

Objective: To establish an improvement of identification method of Monoammonium Glycyrrhizinate in Compound Ammonium Glycyrrhetate Injection.

目的：建立复方甘草酸单铵注射液中甘草酸单铵鉴别方法的改进方法。

The detection sensitivity of the new method is shown higher than the old method that it can be used to the identification of Monoammonium Glycyrrhizinate in Compound Ammonium Glycyrrhetate Injection.

本方法的检测灵敏度较原方法高，可用于复方甘草酸单铵注射液中甘草酸单铵的鉴别。

Studied the extraction and purification of glycyrrhiza acid from licorice residue,obtained the better process condition through effect factors and orthotropic experiments,the yield of monoammonium glycyrrhizinate was 1.45% and content was 95%.

对超临界萃取后固形物提取纯化甘草酸的工艺进行了研究，通过影响因素试验和正交试验得出最佳工艺条件，甘草酸铵收率1.45％，纯度95％。

Stearyl 18B Glycyrrhetinate,18B Glycyrrhetinate,Monoammonium Glycyrrhizinate, Dipotasssium Glycyrrhizinate.

主要产品：甘草次酸硬脂基脂，甘草次酸，甘草酸单铵盐，甘草酸二钾盐

18β-glycyrrhizic acid and 18α-glycyrrhizic acid up-regulate and down-regulate CYP3A1 expression at the transcriptive levels.

18β-甘草酸和18α-甘草酸在转录水平上分别上调和下调大鼠肝细胞CYP3A的表达。

The therapy of protection of liver function is very necessary: diammonium glycyrrhizinate can recover the non-specific damage of liver cells, Fufangdanshen can improve the microcirculation of liver, and tiopronin and reduced glutathione has the unique function to recover liver damage caused by fat invasion. Of 168 cases, 60 cases (35.7%) show exacerbation of liver function after using fat-reducing drugs for 1-2 weeks. Of 41 cases (male 36 and female 5) with the complication DM2, 58.5%(24/41) of cases also show exacerbation of liver function after using sugar-reducing drugs.

保肝治疗非常必要，甘草酸二铵有修复非特异性的肝细胞损伤的作用，复方丹参可以改善肝脏微循环；硫普罗宁或还原性谷胱甘肽，对于脂肪肝之由于脂肪浸润引起的肝细胞损伤的修复有独到的作用。168例中有60例（35.7%）因用降脂药物1～2周出现肝功能异常的加重；合并2型糖尿病的41例（男36例，女5例）患者中有58.5%(24/41)的人用降糖药物后也出现肝功能异常的加重。

Diet-controlling and movement for weight-reducing are the utmost method for the therapy of NAFL. The therapy of protection of liver function is very necessary: diammonium glycyrrhizinate and Fufangdanshen as basic drugs and tiopronin as main drugs. We should be prudent to use sugar-reducing drugs. And we shouldn't advocate to use fat-reducing drugs routinely.

控制饮食和运动以减肥是治疗NAFL的首要措施；保肝治疗非常必要，甘草酸二铵和复方丹参作为基本用药，硫普罗宁或还原性谷胱甘肽作为必选药物；慎用降糖药物，不提倡常规使用降脂药物。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。