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RESULTS: N-octyl-N'-succinyl chitosan possessed stronger affinity than control cell lines and growth inhibition with the four kinds of tumor cells.

结果:N-正辛基-N'-琥珀酰基壳聚糖对4种肿瘤细胞亲和性明显强于空白细胞株(P.01),并具有一定的肿瘤抑制作用。

OBJECTIVE: To prepare cholesterol succinyl chitosan anchored liposomes, and to investigate the effect of CHCS anchored liposomes on the release property in vitro of loading drugs taking epirubicin as a model drug.

目的:通过"锚定"的方式制备胆甾醇琥珀酰基壳聚糖锚定脂质体,并以表阿霉素作为模型药物,考察其对包载药物体外释放性质的影响。

Methods Thirty adult patients,ASA grade Ⅰ~Ⅱ,scheduled for selective craniotomy,were randomly allocated to receive intravenous infusion of hypertonic saline,succinyl gelatin,or Lactate Ringer's,with 10 cases in each group.

方法30例择期行开颅手术患者,ASAⅠ~Ⅱ级,随机分为高渗盐水组、琥珀酰明胶组和乳酸钠林格氏液组,每组10例,术前缓慢放血,放血量以放血后血细胞比容不低于25%为原则,三组于放血同时分别输入HS、GEL和LR维持正常血压。

N-octyl-N'-succinyl chitosan may possibly be a tumor-targeting carrier.

N-正辛基-N'-琥珀酰基壳聚糖有望作为抗肿瘤药物的靶向载体。

Self-assembled nanomicelles of N -cholesterol succinyl O -carboxymethyl chitosan were prepared by probe sonication method. The amphiphilic property and the critical micelle concentration of CCMC were determined by fluorescence probe technique; the morphology and the size of CCMC self-assembled nanomicelles were analyzed by transmission electron microscopy and the dynamic laser light scattering.

以 N -胆甾醇琥珀酰基- O -羧甲基壳聚糖(CCMC,胆甾醇基取代度6.9%)为原料,在水溶液中通过探头超声处理制备其自组装凝胶纳米胶束,采用稳态荧光探针法考察临界胶束浓度,并通过透射电镜和动态激光散射仪检测胶束的形态大小。

The main study of this dissertation is shown as follows.1.Two new amphiphilic steroid derivatives(N-cholesteryl succinyl glucosamine, CSG and N-deoxycholyl glucosamine,DCG) were designed and synthesized.Their chemical structures have been confirmed by means of Fourier Transform Infrared Spectrometry,Nuclear Magnetic Resonance Spectrometry and Mass Spectrometry.

设计、合成了新型的两亲性甾族衍生物—N-胆固醇琥珀酰基氨基葡萄糖(N-cholesteryl succinyl glucosamine,CSG)和N-脱氧胆酰基氨基葡萄糖(N-deoxycholyl glucosamine,DCG),并采用傅立叶红外波谱仪(Fourier TransformInfrared Spectrometry,FT-IR)、核磁共振波谱仪(Nuclear Magnetic ResonanceSpectrometry,NMR)和质谱等分析仪器对原料、中间产物和最终产物的化学结构进行表征。

Diethylthiourea, doxylamine succinate, kojic acid, methimazole and sulfamethazine were evaluated for the first time.

二乙基,doxylamine琥珀,曲酸,他巴唑和磺胺二甲嘧啶)的首次评价。

Drugs (methimazole, methylthiouracil, propylthiouracil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole.

抗甲状腺?药物(他巴唑,甲基硫氧嘧啶,丙基硫氧和硫氧嘧啶);一些镇静剂(doxylamine琥珀和苯巴比妥),以及包括系统性真菌抗生素灰黄霉素,安体舒通的利尿一些其他药物,以及抗菌磺胺类药物和磺胺二甲嘧啶。

Sulfa drugs, such as cotrimoxazole, isoxazole sulfonamides, sulfa Micronesia acridine, Sulfamethoxazole, Sulfonamides methoxy pyrazine, sulfonamides Formamidine, probenecid, double pyrimidine films, bacteriostatic sulfonamide, trimethoprim, sulfathiazole, such as amber.

磺胺类药物,如复方新诺明、磺胺异恶唑、磺胺密啶、磺胺甲基异恶唑、磺胺甲氧吡嗪、磺胺脒、丙磺舒、双嘧啶片、制菌磺、甲氧苄氨嘧啶、琥珀磺胺噻唑等。

Two artificial antigens Bz_HS_protein and Bz_SO 2_protein have been synthesized by the succinic anhydride_carbodiimide method and the sulfonyl chloride method separately.

琥珀酸酐-碳二亚胺法和氯磺化法合成了毕兹的两种人工抗原Bz_HS_protein和Bz_SO2_protein。

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