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Objective To investigate the resistance of erthromycin and clidamycin in Gram-positive coccus and help to reasonably use clindamycin. Methods Use of MIC to detect 578 isolates randomly collected from January to September in our hospital, double antimicrobial agents detect the clidamycin induce test.

目的 探讨阳性球菌中红霉素诱导克林霉素耐药性的发生情况,合理指导临床用药方法 MIC法检测某院579株阳性球菌对克林霉素和红霉素的耐药情况;双纸片法检测可诱导克林霉素耐药。

In this experiment, 1.5% optimized microbial populations were added. The optimized microbial populations were primarily identified as Pseudomonas, Micrococcus, Actinomayces, Penicillium and Aspergillus.

在实验装置内加入了1.5%的优化菌群制剂,优化出的菌群初步鉴定主要有:假单胞菌属、微球菌属、放线菌属、真菌类的青霉属和曲霉属等。

A bacteriocin-like substance producing strain T12 was screened from 212 lactic acid bacteria isolated from intestine of healthy pigs by paper disk test and was identified as Lactobacillus. The supernatant of T12 exhibited strong inhibitory activity against the gram-positive bacteria, including Micrococcus lysodeikticus, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. A strong activity was also observed against the gram–negative bacteria and some eumycete, such as Escherichia coli, Salmonella typhimurium and Fusarium graminearum.

通过滤纸片法从健康肉猪猪大肠、小肠中分离得到212株抗生物质产生菌,以杯碟法复筛,得到1株对溶壁微球菌、金黄色葡萄球菌、枯草芽孢杆菌、蜡状芽孢杆菌等革兰氏阳性菌和大肠杆菌、鼠伤寒沙门氏菌等革兰氏阴性菌以及部分真菌如禾谷镰刀霉均有强烈抑制作用的乳酸菌。

Com-pound 11 showed best antifungal activity with broad antifungal spectrum and proved to be more active against Cryptococcus neo-formans, C andida albicans, Microsporum lanosum and Trichophyton rubrum than ketoconazole.

化合物11的抗菌谱最广,抗真菌活性最高,对新型隐球菌、白色念珠菌、羊毛状小孢子菌和红色毛癣菌的抗菌活性比酮康唑高,有进一步开发的价值。

Among pathogens , the most common pathogens associated with VAP were Pseudomonas aeruginosa ( 3013 %), Acinetobacter baumanii (1115 %), Klebsiella pneumoniae ( 1017 %), Escherichia coli ( 716 %) and S taphylococcus aureus ( 618 %). Their multiple drug2resistance to antibiotics was serious. Drug sensitivity tests indicated that the GNB had lower drug2 resistance to such antibiotics as imipenem , amikacin , piperacillin/ tazobactam , ceftazidime , cefepime , cefoperazone/sulbactam , ciprofloxacin and ticarcillin/ clavulanate. Polymicrobial pathogens were more isolated in late2onset VAP than in early2onset VAP.

结果 共检出致病菌383 株,革兰阴性细菌占8411 %,其中非发菌占5114 %,肠杆菌科占3216 %,革兰阳性球菌占1218 %,其中MRSA和MRSE 占615 %,真菌占311 %;前5 位致病菌分别为铜绿假单胞菌(3013 %)、鲍氏不动杆菌(1115 %)、肺炎克雷伯菌(1017 %)、大肠埃希菌(716 %)、金黄色葡萄球菌(618 %)等;药敏结果显示这几类菌株的多重耐药现象严重,较为敏感的抗菌药物有亚胺培南/西司他丁、阿米卡星、哌拉西林/他唑巴坦、头孢他啶、头孢吡肟、头孢哌酮/舒巴坦、环丙沙星及替卡西林/克拉维酸等,革兰阳性细菌均对万古霉素敏感;迟发性VAP 的混合培养比例显著高于早发性VAP。

Organisms culture included: 5 Staphylococcus aureus, 2 methicillin-resistant S. aureus, 5 non–S. aureus, 5 Propionibacterium acnes, 3 Escherichia coli, 2 Enterococcus,2 Enterobacter, 2 Protes in 2 patients each.

细菌培养的结果为:5例出现金葡菌;2例出现耐青霉素金葡菌;5例非硫金葡菌;5例短棒杆菌;3例大肠杆菌;2例肠道球菌;2例肠杆菌;2例真菌感染。

The Etest is an altenmative to agar dilution method for gonococci susceptibility testing to ceftriaxone,penicillin and ciprofloxacin due to its rapid,effectiveness and significant relationship with agar dilution method.

菌株来源实验菌株均从我所STD门诊患者的泌尿生殖道分泌物中分离得到,所有菌株经革兰染色、氧化酶试验和糖发酵试验证实为淋球菌传代一次,洗于脱脂牛奶中,于- 78℃低温冰箱冻存备用。2 。

85 And 119486/79. They are a novel type of antibiotic having both the wide antibacterial spectrum and high safety of penicillin and cephem antibiotics belonging to beta -lactam antibiotics, as well as the potent antibacterial activity and high beta -lactamase stability of carbapenem antibiotics.Sodium-(5R, 6S)-6-[-1-hydroxyethyl]-7-oxo-3- [-2-tetrahydrofuryl]-4-thia-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylate 5/2 hydrate (faropenem sodium, hereinafter referred to as compound 1) is currently used as an oral drug for various infectious diseases and is reported to show potent antibacterial activity against not only methicillin-sensitive Staphylococcus aureus, Streptococcus pyrogenes and Streptococcus pneumoniae but also gram-positive bacteria for which conventional beta -lactam drugs have proved ineffective such as penicillin-resistant pneumococci, oral staphylococci and enterococci, also showing a wide antibacterial spectrum covering gram-negative bacteria such as Haemophilus influenzae and anaerobic bacteria such as the genus Bacteroides, which activity is due to its novel skeleton penem ring (Kagaku Ryoho no Ryoiki The Field of Chemotherapy, Vol.

他们是一种新型的抗生素都具有广泛的抗菌谱和高度的安全青霉素和cephem抗生素,属于β-内酰胺类抗生素,以及作为强大的抗菌活性和高β-内酰胺酶稳定的碳青霉烯类antibiotics.sodium -( 5 R , 6 S )-6 -[ - 1 -羟乙基] - 7 -氧- 3 - [ - 2 - t etrahydrofuryl] - 4 -硫杂- 1 -氮杂双环[ 3 。2.0]庚- 2 -节能- 2 -羧酸5 / 2水合物(法罗培南钠,以下简称为化合物1 )是目前用来作为口服药物,为各种传染病和报道,以显示强大的抗菌活性,不仅对甲氧敏感的金黄色葡萄球菌,链球菌pyrogenes和肺炎链球菌,但也克阳性菌为常规β-内酰胺类药物已证明无效,如青霉素耐药pneumococci ,口腔葡萄球菌和肠球菌,也显示出广泛的抗菌谱,包括革兰阴性菌如流感嗜血杆菌和厌氧菌如属杆菌,这活动是由于其新颖的骨架青霉烯环((化学ryoho没有ryoiki领域的化疗),第13卷,第10号,第74-80 , 1997年)。

The probe of chip includes the entire genomic DNA of at least ten thiobacillus ferrooxidans, at least two thiobacillus acidophilus sulfur oxides, at least one eosinophils thiobacillus, at least one acidithiobacillus albertensis bacteria, at least six thiobacillus oxidation of ferrous - Lo, at least eight heterotrophic bacteria acidophilus, at least one metal leaf sulfur bacteria, at least one Acidianus tengchongensis, at least a Metallosphaera sedula and at least two of thermophilic bacillus curing.

该芯片的探针包括至少10株氧化亚铁硫杆菌、至少2株嗜酸氧化硫硫杆菌、至少1株喜温嗜酸硫杆菌、至少1株Acidithiobacillus albertensis菌、至少6株氧化亚铁微螺菌、至少8株异养嗜酸菌、至少1株金属硫叶菌、至少1株嗜酸两面菌、至少1株勤奋金属球菌和至少2株嗜热硫化杆菌的全基因组DNA。这种芯片,能够检测酸性环境中丰度较低的微生物,具有高通量、同时、快速、准确、灵敏地分析酸性环境中微生物群落组成的优点。

The result of durg resistance suggested that Gram positive coccus were shawed very serious,but still be senstive about vancomycin relatively.

分离率较高的依次为大肠埃希菌、葡萄球菌属、变形杆菌属、枸橼酸杆菌属、肺炎克雷伯菌、肠球菌属、铜绿假单胞菌。

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