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The chitosan-based microsphere delivery system enhanced the humoral immune response induced by polytope DNA vaccine.

壳聚糖微球疫苗投递系统可提高多表位DNA疫苗的免疫应答效果。

The magnetic polymer complex microspheres with core-shell structure were synthesized by copolymerizing of pyrrolidone acid and methacrylic on surface of Fe3O4 particles modified by OP, using potassium persulfate as a initiator.

以N-乙烯基吡咯烷酮和甲基丙烯酸为原料,过硫酸钾为引发剂,采用乳液聚合的方法共聚包埋自制的磁流体Fe3O4,制得了Fe3O4/P核壳复合微球。

The prepara tion,characterization,mechanism,the effect on shells from reactional condi-t ion and the development trend of hollow spheres are summarized.

本文介绍了纳米金属氧化物空心球的制备及表征方法,并对其形成机理、反应条件对壳层的影响以及存在的问题及今后的发展方向进行了初步探讨。

No significant difference was found between the volumes of GM, right caudate nucleus, globus pallidus, bilateral frontal lobes, anterior cingulate gyri, thalami, hy, and amygdalae in both groups.

结果 与正常对照组相比,OCD患者组的全脑白质、双侧壳核体积增加;左侧尾状核和苍白球体积减小(P<0.05)。

The varying of expression of Cfos in different phases and different brain tissue including caudate nucleus, putamen, globus pallidus, hippocampus, nuclei ventrolaterales thalami, parvocellular reticular nucleus, and dorso lateral magnocellular nucleus were examined by immunohistochemical technique.

采用Cfos免疫组化染色,在显微镜下观察Cfos于不同时相在脑膜、脑皮质区及相关核团如尾壳核、苍白球、海马、背侧丘脑腹后外侧核、小细胞网状核、背侧旁巨细胞核的阳性细胞数。

(1) Verification of the expressions of Cfos in caudate nucleus, putamen, globus pallidus, hippocamp, nuclei ventrolaterales thalami, parv ocellular reticular nucleus, dorso lateral magnocellular nucleus after rats subarachnoid hemorrhage are variation with different phases.(2) There are certain relationships between subarachnoid hemorrhage and different phases.

(1)大鼠蛛网膜下腔出血后不同时相Cfos在脑膜、脑皮质区及尾壳核、苍白球、海马、背侧丘脑腹后外侧核、小细胞网状核、背侧旁巨细胞核中都有表达且表达量随时相改变;(2)大鼠蛛网膜下腔出血后相关症状与不同时相Cfos在脑中表达之间存在着相关联系,具有规律性。

Purpose Perfusion-weighted images were acquired to analyze quantitatively the changes of cerebral hemodynamics in adult unmedicated patients with obsessive-compulsive disorder after symptom provocation.

高分辨率MRI三维全脑结构像发现OCD成年患者脑白质、尾状核、壳核和苍白球体积的改变,为OCD病理生理学研究提供重要的神经影像学依据。

Polyvinylpyrrolidone/vanadyl glycolate VO(OCH2-CH2O core-shell microspheres were assembled by soft-templating method using vanadyl acetylacetone VO(acac2 as raw materials.

以自制的二乙酰丙酮氧钒VO(aca2为原料,通过软模板法组装出聚乙烯吡咯烷酮/钒前驱体核壳结构的复合微球。

Methods:All the 40 Winstar rats were divided into four groups:group A:the rats were fed with normal diet,group B:the rats were fed with only high|cholesterol diet(no vitamin D3),group C:the rats were treated with one intramuscularly injection of vitamin D3(300 000 U/kg) and were denudated of endothelium,followed by high|cholesterol diet,group D:the rats were treated with 5% chitosan added into the diet besides treatment as group C.Ninety days later,the formation of atherosclerosis plaques and the activities of nitric oxide synthase in aortas in the four group rats were investigated.

40只Wistar大鼠均分为:A组;B组:饲以高脂饲料(不含维生素D3);C组:一次性给予大鼠维生素D3(30万U/kg体重)肌肉注射,以球囊损伤主动脉内皮和饲以含维生素D3(1.25×106U/kg)的高脂饲料;D组在C组的基础上饲料中加入5%壳聚糖。90 d后检测主动脉动脉粥样硬化斑块形成及NOS的活性。

For PNA selective targeting to a monocyte– macrophage compartment, we evaluated two novel delivery systems based on polymeric core-shell microspheres and autologous loaded opsonized RBC.

为实现肽核酸对单核细胞-巨噬细胞体系的选择性靶向作用,我们对基于聚合核-壳微球和自体载药调理素化的RBC这两种传导系统进行了评估。

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