环胺

Heterocyclic nitramine RDX and HMX (cyclotetramethylene tetranitramine) are high explosives widely used with better comprehensive properties.

环杂硝胺RDX和HMX是使用广泛、综合性能很好的猛炸药。

We observed that cyclophosphamide-immunosuppressed adult mice were Susceptible to acute infection leading to death.4-8 week old C57 mice or outbred Kunming strain mice inoculated in-tracerebrally with HFRS virus A-16 strain and immunosuppressed with four 50mg/kg CY doses at days -1,+1,+ 2,+ 4 (day O:virai infection), developed a lethal disease94% m...

在第-l、+1，+2、+4天注射环磷酰胺50mg/kg体重(第0天感染病毒)，可使小鼠由隐性感染变为急性致死性感染，病死率为94％。在病死动物的脑，肺、肝、脾和肾等器官中，检查翻HFRS病毒抗原。这些器官显示微血管系统和实质组织的病变。这种成龄鼠模型可用于本病的研究。

The semi-aromatic polyamide containing oxazole ring of the invention has the advantages of easy processing and high heat-resistant temperature.

本发明含唑环半芳香聚酰胺具有易加工和耐热温度高的优点。

Disclosed is a semi-aromatic polyamide containing oxazole ring and the related synthesis method, relating to a semi-aromatic nylon and the synthesis method.

一种含唑环半芳香聚酰胺及其合成方法，它涉及一种半芳香族尼龙及其合成方法。

The synthesis method of the invention is as follows: first, 5-amino-2-(p-aminophenyl)- benzoxazole and aliphatic diacid are respectively recrystallized; NMP is distilled; solubilizer is dried; second, in an atmosphere of nitrogen, after Py and NMP are mixed evenly and added to a sealed reactor, the solubilizer is added into the reactor, followed by the 5-amino-2-(p-aminophenyl)- benzoxazole, then the mixture in the reactor is stirred; second, in an atmosphere of nitrogen, the mixture in the second step is stirred and heated to 50-150 DEG C, then the aliphatic diacid is added, followed by TPP for condensation; fourth, after methanol is poured into the reactor, the sediment is separated out from the mixture, filtered, washed and dried, so the semi-aromatic polyamide containing oxazole ring is obtained.

本发明的合成方法如下：一、分别重结晶5-氨基-2-苯并唑与脂肪族二酸；蒸馏NMP；干燥增溶剂；二、在氮气气氛下，Py与NMP混匀后加入密封的反应器中，再加入增溶剂，然后加入5-氨基-2-苯并唑，搅拌；三、在氮气气氛下，将步骤二的混合液搅拌并升温至50℃～150℃后加入脂肪族二酸，再加入TPP后缩聚；四、再倾入甲醇析出沉淀，过滤，清洗沉淀，再干燥；即得到含唑环半芳香聚酰胺。

One of these compounds, 2-diethyl- aminoethyl-5--(4-methoxybenzylidene) cyclo- pentanone hydrochloride (T81) possessed sig- nificant antiinflammatory and analgesic ac- tivity when administered orally.

Ⅲ类化合物完全无抗癌活性，对其中一个化合物2-二乙胺乙基-5--（4-甲氧基苯亚甲基）环戊酮盐酸盐（T81）试验结果表明，它经口给药时具有显著的抗炎、镇痛活性。

Methods One injection was performed intra peritoneally with GAD purified from pig brain, together with Freund incom plete adjuvents, into female NOD mice at the age of 4 weeks as treated gro up (n=32), other 19 mice were injected FIA 100 μl alone as control group.

用猪脑GAD和不完全弗氏佐剂混合后给4周龄雌性NOD小鼠腹腔注射(32例)，同时单独注射等量FIA作为对照组。8周龄时腹腔注射环磷酰胺以加速糖尿病。

MethodsThe transplanted tumor model of the mouse S180 sarcoma was established.Fifty mice were randomly divided into five groups,the control group,the CTX group,the Gecko group.They were treated respectively with oral administration of saline,and intraperitoneal injection of CTX 100 mg/kg only one time,oral administration of Gecko in doses of 13.5,9,4.5 g/kg,one time a day.After 14 days,the anti-tumor activity was evaluated by tumor tissue weighing. The impact on immune organ was detected by accounting thymus index, spleen index and the number of peritoneal macrophage which phagocytose chicken red blood cells.The protein express of vascular endothelin growth factor and basic fibroblast growth factor were detected by SABC immunohistochemistry.

方法建立移植瘤小鼠S180肉瘤模型，将50只雌鼠随机分为对照组、环磷酰胺组、壁虎高组、中组、低组共5组，分别给于生理盐水灌胃1次/d，CTX（100 mg/kg）腹腔注射1次，壁虎高、中、低组（13.5，9，4.5 g/kg），每天灌胃1次。14 d后，称取荷瘤小鼠瘤重、胸腺重、脾脏重，计算抑瘤率、胸腺指数、脾脏指数，观察腹腔巨噬细胞吞噬鸡血红细胞实验指标；用SABC免疫组化法检测血管内皮生长因子、碱性成纤维细胞生长因子的蛋白表达，TUNEL方法检测细胞凋亡率。

Ifosfamide ; Cancer chemotherapy ; Lung cancer ; Non一Hodgkin's lym- phoma

异环磷酰胺；肿瘤化疗；肺癌；非霍奇金淋巴瘤

By using 4-chloro-5-nitro phthalimide as raw material and through aminoysis, reduction, cyclization and hydrolysis, end-produce benzimidazole-5,6-diformic acid is prepared.

本发明公开了一种苯并咪唑－5，6－二甲酸的制备方法。该方法是以4－氯－5－硝基邻苯二甲酰亚胺为原料，依次经过氨解、还原、环合、水解反应过程，制得最终产品苯并咪唑－5，6－二甲酸。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失