环甲的

In our paper,1-hexylcarbamoyl-5-fluorouracils and1-cyclohexyl-carbamoyl-5-fluorouracils were prepared through 5-fluorouracil reacting with hexyl isocyanate or cyclohexyl isocyanate by using dimethylaminopyridine as the catalyst.

以5-氟尿嘧啶(5-FU)、正己基异氰酸酯和环己基异氰酸酯为原料，在N，N-二甲氨基吡啶的催化下，通过N-脲化反应制成1-己基氨基甲酰基-5-氟尿嘧啶及1-环己基氨基甲酰基-5-氟尿嘧啶。

Goal compound synthesis namely: Take the vanillic acid as outset raw material, obtains 4- hydroxyl - 3- anisole methyl formate with the methyl alcohol reflux conditions, then after the etherification, the nitration, the return to original state, the ring closure response obtains 6- methoxy - 7- animal pen oxygen radical kui zuo lin - 4- alkone, then passes through the chlorination, the substitution aniline, to escape responses again and so on animal pen oxygen radical, etherification to obtain the goal compound; The goal compound and the diethylamine had the amine substitution reaction to obtain TM1, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(N, N- two ethyl aminos) third oxygen radical] kui zuo lin; Through zuo has the etherification with the Austria niter to respond obtains TM2, namely 4- benzene amino - 6- methoxy - 7- [2- hydroxyl - 3-(2- methyl - 5- nitryl imidazole) third oxygen radical] kui zuo lin.

目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Synthesis of target compounds namely: to vanillic acid as the starting material with methanol under reflux conditions for 4 - hydroxy -3 - p-methyl, then ether, and nitration, reduction, cyclization reaction 6 - methoxy -7 - benzyloxy-quinazoline -4 - one, and then by the chloride in place of aniline, benzyloxy-off, such as etherification reaction of the target compounds; target compounds with the second and third occurrence of substitution reactions of amines by the TM1, that is, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(N, N-diethyl amino) oxy c] quinazoline; with ether occurred Ornidazole reaction of TM2, namely, 4 - amino-benzene -6 - methoxy -7 - [2 - hydroxy -3 -(2 - methyl -5 - nitroimidazole) C oxy] quinazoline.

本论文以嘌呤类似物喹唑啉为母核，分别在其4位和7位引入结构多样的取代苯氨基和柔性侧链，设计了一系列4-取代苯胺基-6-甲氧基-7-(2-羟基取代丙氧基)喹唑啉类化合物。目标化合物的合成即：以香草酸为起始原料，与甲醇回流条件下得到4-羟基-3-甲氧基苯甲酸甲酯，然后经过醚化、硝化、还原、环合反应得到6-甲氧基-7-苄氧基喹唑啉-4-酮，然后再经氯化、取代苯胺、脱苄氧基、醚化等反应得到目标化合物；目标化合物与二乙胺发生胺取代反应得到了TM1，即4-苯氨基-6-甲氧基-7-[2-羟基-3-丙氧基]喹唑啉；通过与奥硝唑发生醚化反应得到TM2，即4-苯氨基-6-甲氧基-7-[2-羟基-3-(2-甲基-5-硝基咪唑)丙氧基]喹唑啉。

Both styrene conversion and epoxide selectivity can be obviously improved when a solution of N,N-dimethylformamide and dimethyl sulfoxide with an appropriate proportion is used.

使用适当比例的N，N-二甲基甲酰胺和二甲亚砜的混合溶剂能够显著提高苯乙烯的转化率和环氧化物的选择性。

The results of bioassay suggest that 2-methylthio-6-methyl-4-substituted pyrimidine and 4, 6-dimethoxy-2-substituted pyrimidine derivatives show herbicidal activity. In these target compounds, 4, 6-dimethoxy-2-substituted pyrimidine benzylamine and 4, 6-dimethoxy-2-Substituted pyrimidine benzylidene amine exhibit good herbicidal activity, and the herbicidal will be affected by the substituents in the benzene ring.

对分子库中的目标分子进行了生物活性筛选研究，发现其中的2-甲硫基-6-甲基-4-取代嘧啶衍生物和4，6-二甲氧基-2-取代嘧啶类化合物显示出除草活性，其中4，6-二甲氧基-2-取代嘧啶苄胺类化合物和4，6-二甲氧基-2-取代嘧啶亚苄胺类化合物具有较好的除草活性，而且其活性和苯环上的取代基有关。

Our company supply raw materials and related intermediates as follows: Second dibutyryl cAMP calcium, voriconazole, terbinafine, vecuronium amines, cAMP, thiamphenicol, a chlorophenol hydrochloride esters, card network sodium phosphate tilmicosin, foscarnet, lornoxicam, Tilmicosin, Cephalosporium aspirin acid, ceftiofur hydrochloride, ceftiofur sodium, Ozagrel, ondansetron hydrochloride ketones, hydroxyurea, ticarcillin sodium, telmisartan, esmolol hydrochloride, hydrochloric acid Daguan Nikkomycin, adefovir dipivoxil, buflomedil hydrochloride, granisetron hydrochloride, warfarin sodium,-methyl gabexate acid, nicergoline, pantoprazole sodium,·, tegafur, cefepime hydrochloride, vecuronium bromide, hydrochloric acid meclofenoxate, sertraline hydrochloride, Cefonicid amine salt, aztreonam, ticarcillin, cefdinir, cefodizime sodium, sodium ferulate, colloidal pectin secretion, 2,3 - cyclopentene and pyridine, Piperacillin acid, cefetamet US-acid, hydrochloride Cefmenoxime ,3-TZ, 2 - deoxy-D-glucose, two-amidine urea benzene, sodium Cefonicid, Cefonicid intermediates, ester Cefamandole sodium, Cefalotin acid, intermediates cefpirome, cefepime sulphate, cefepime intermediate nucleus of cefepime, cefpirome nucleus, Cefamandole sodium, ceftriaxone new active ester, oxaliplatin, cyclophosphamide vary gland amines, polyene match him.

我公司供应的原料药及相关中间体为：二丁酰环磷腺苷钙、伏立康唑、盐酸特比萘芬、维库溴胺、环磷腺苷、甲砜霉素、盐酸甲氯酚酯、卡络磺钠、磷酸替米考星、膦甲酸钠、氯诺昔康、替米考星、头孢匹胺酸、头孢噻呋盐酸盐、头孢噻呋钠、奥扎格雷、盐酸恩丹西酮、羟基脲、替卡西林钠、替米沙坦、盐酸艾司洛尔、盐酸大观霉素、阿德福韦酯、盐酸丁咯地尔、盐酸格拉司琼、华法林钠、甲磺酸加贝酯、尼麦角林、泮托拉唑钠、普拉洛芬、替加氟、盐酸头孢吡肟、维库溴铵、盐酸甲氯芬酯、盐酸舍曲林、头孢尼西胺盐、氨曲南、替卡西林、头孢地尼、头孢地嗪钠、阿魏酸钠、胶体果胶泌、2，3-环戊烯并吡啶、哌拉西林酸、头孢他美酸、头孢甲肟盐酸盐、3-TZ、2-脱氧-D-葡萄糖、双脒苯脲、头孢尼西钠、头孢尼西中间体、头孢孟多酯钠、头孢噻吩酸、头孢匹罗中间体、头孢吡肟硫酸盐、头孢吡肟中间体、头孢吡肟母核、头孢匹罗母核、头孢孟多钠、头孢曲松新型活性酯、奥沙利铂、异环磷腺胺，多烯他赛。

A novel method for determination of benzoyl peroxide with spectrophotometry was developed. Inclusion ratio of β cyclodextrin to dibenzoy peroxide and benzoic acid is obtained with spectrophotometry.The mechanism of the inclusion was studied,too. The results showed that β-CD react with dibenzoyl peroxide to form a 1:1 or 2:1 host-guest complex, with the apparent formation constants of 5.0× 10~2and 2.5× 10~4 , respectively.β-CD reacts with benzoic acid to form a 1:1 host-guest complex with the apparent formation constant of 6.9 × 10~2 after the dibenzoyl peroxide was reduced by hydroxyl ammonium chloride.

建立了用β环糊精测定过氧化苯甲酰的分光光度法，并测定了β环糊精与过氧化苯甲酰和苯甲酸的包结比，随着β-CD浓度的增大，可与BPO分别形成1：1或2：1的包容络合物，包结常数分别为5.0×10~2和2.5×10~4，与苯甲酸形成1：1的包容络合物，包结常数为6.9×10~2；由于包结物的吸光度值比过氧化苯甲酰的吸光度值大大增加，建立了一种当β-CD存在下，在水溶液中测定过氧化苯甲酰的方法。

Personally,i believe i am just the person who can best fill this position.to begin with,my major , my degree exactly meet the basic requirements of the advertised position.second,i have 6 years of experience rotating in surgical departments.as having pererrorerrorerrorformed 2000 or so procedures,i am able to deal with most basic clinical problems in most surgical departments,and i am good at all kinds of basic surgical skills and procedures,including tracheotomy,endotracheal intubation,thyrocricocentesis,central vein catheterization,external lateral ventricular drainage,closed drainage of thoracic cavity,peritoneocentesis,suprapubis vesicopun c ture,gastrointestinal decompression,urethral catheterization,cranial traction,bone marrow pun c ture,plaster immobilization, routine fracture fixation and traction, phlebotomy , excellent debridement and suturing, and so on.conclusively,i am competent in most basic surgical work and good at organising residents on first aid work.

我自信我正是贵公司所需要的雇员。首先，我的学历，学位和工作经验正符合贵公司在网站中告知的该职位的应聘条件。其次，我有 6 年的外科各科室轮转的工作经历。毕业至今我已经参与完成大小手术 2000 台次，鉴于此，我能处理各外科科室的基本临床问题，熟练进行外科各科室的基本临床操作和手术，比如气管切开术，气管内插管术，环甲膜穿刺术，中心静脉置管术，侧脑室外引流术，胸腔闭式引流术，腹腔穿刺术，胃肠减压术，耻骨上膀胱穿刺术，导尿术，颅骨牵引术，骨髓穿刺术，各种骨折固定和牵引术，静脉切开术，娴熟的清创缝合术等。总的说来，我能胜任外科各科室临床常规工作并组织住院医师进行急救工作。

Rhesus macaques could be infected by the inoculation of thyrocricoid puncture. And it was proved to be a good method for the similar experiments.

环甲膜穿刺接种恒河猴感染H5N1流感病毒具有很高的可行性，是恒河猴感染H5N1流感病毒和造模的良好途径，并为其它通过呼吸道感染的病原的造模和研究工作提供参考。

Methods: A randomized, single blind controlled clinical design was used to accomplish the series clinical trials included 123 cases. The troop of gatifloxation injection with sodium chloride included 20 cases in gatifloxation group and 23 cases in ciprofloxation group; The troop of gatifloxation injection with glucose included 21 cases in gatifloxation group and 19 cases in levofloxacin group; The troop of gatifloxation pivoxil included 19 cases in gatifloxation group and 21 cases in ciprofloxation group. The antibacterial activity of clinical isolates were detected by scrips which contain gatifloxation(5ug/L), levofloxacin (5ug/L), ciprofloxation (5ug/L), spafloxation(5ug/L), cefotaxime(30ug/L), penicillin(10U/L) respectively. The MICs of sixkinds of antibiotics were detected by 2-fold agar dilution method. Result: The common data of patients in the two groups of 3 troops were similiar.

采用区组分层均衡随机单盲试验设计，分别完成甲磺酸加替沙星氯化钠注射液组试验药20例及对照药23例、甲磺酸加替沙星葡萄糖注射液组试验药21例及对照药19例、甲磺酸加替沙星片剂组试验药19例及对照药21例共123例感染患者的临床试验；用K-B法测定临床分离致病菌对加替沙星(5ug／L)、左氧氟沙星(5ug／L)、环丙沙星(5ug/L)、司帕沙星(5ug/L)、头孢噻肟(30ug／L)、青霉素(10U／L)纸片的敏感性，再用按美国国家实验室标准委员会(National Committee for Clinical Laboratory Standards，NCCLS)推荐的琼脂平皿对倍稀释法测定临床分离菌株对加替沙星、左氧氟沙星、环丙沙星、司帕沙星、头孢噻肟、青霉素的最低抑菌浓度(Minimum Inhibitory Concentration，MIC)以了解其体外抗菌活性。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了