环烯

Photoreactions of 8 with 15-19, on the other hand, furnished the corresponding [2+2] cyclobutane products and the annulation products together.

二氯马来酰亚胺（8）与15—19的光化反应中则分别得到相应[2+2]的环丁烷产物和增环产物，在与19的反应中，还得到由环丁烷产物脱氯化氢后得到的环丁烯开环的二烯产物。

They were eucalyptol, bicyclo［2.2.1］heptan-2-one,1,7,7-trimethyl-,(1R)-, borneol, 1-methyl-2-(1-methyl ethenyl)-(1R-cis)-cyclobutaneethanol, limonene, 1-hydroxymethyl-7,7-dimethy lbicyclo［2.2.1］heptan-2-one,-spathulenol, 3,7,11,15-Tetramethyl-2-hexadecen-1-ol, isocitronellol,-9-Octadecenoic acid, heneicosane, respectively.

阿给中共有11个阿给炭没有检测出的成分，包括桉油精、D-樟脑、冰片、(1R-cis)- 1-甲基-2-(1-甲基乙烯基)环丁基乙醇、二戊烯、1-羟甲基-7，7-二甲基-双环［2.2.1］庚-2-酮、-匙叶桉油烯醇、3，7，11，15-四甲基-2-十六碳烯-1-醇、异香茅醇、-9-十八碳烯酸和廿一烷。

This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

During the investigation of the reactivity of O_SCl_2(PPh_3)_2CH=C(PPh_3CHCH=CH_2 and O_SCl_2(PPh_3)_2CH=C(PPh_3C(=CH_2)CH=CH2, several stable osmacycles with novel structure, such as osmabenzenes, osmafurans, osmacycles containing intramolecular-coordinated allene, intramolecular-coordination osmacycles containing osmacarbene, an osmacyclopentadiene, were isolated during the investigation of the reactivity of O_SCl_2(PPh_3)_2CH=C(PPh_3CHCH=CH_2 and O_SCl_2(PPh_3)_2-CH=C(PPh_3C(=CH_2)CH=CH_2.In addition, some convenient and efficient methods to prepare these osmacycles were developed.

首先，合成出两种具有反应活性的金属杂五元环IC配合物OsCl_2(PPh_3)_2CH=C(PPh_3CHCH=CH_2和OsCl_2(PPh_3)_2CH=C(PPh_3C(=CH_2)-CH=CH_2，并对它们进行了系统表征；进而，研究了这些活性五元配合物的反应性，合成出多种稳定的锇杂环配合物，其中包括锇苯、锇呋喃、含配位联烯的锇杂IC环化合化物、含锇卡宾的IC环化物、首例锇杂环戊二烯化合物等多元化的产物。

Our company supply raw materials and related intermediates as follows: Second dibutyryl cAMP calcium, voriconazole, terbinafine, vecuronium amines, cAMP, thiamphenicol, a chlorophenol hydrochloride esters, card network sodium phosphate tilmicosin, foscarnet, lornoxicam, Tilmicosin, Cephalosporium aspirin acid, ceftiofur hydrochloride, ceftiofur sodium, Ozagrel, ondansetron hydrochloride ketones, hydroxyurea, ticarcillin sodium, telmisartan, esmolol hydrochloride, hydrochloric acid Daguan Nikkomycin, adefovir dipivoxil, buflomedil hydrochloride, granisetron hydrochloride, warfarin sodium,-methyl gabexate acid, nicergoline, pantoprazole sodium,·, tegafur, cefepime hydrochloride, vecuronium bromide, hydrochloric acid meclofenoxate, sertraline hydrochloride, Cefonicid amine salt, aztreonam, ticarcillin, cefdinir, cefodizime sodium, sodium ferulate, colloidal pectin secretion, 2,3 - cyclopentene and pyridine, Piperacillin acid, cefetamet US-acid, hydrochloride Cefmenoxime ,3-TZ, 2 - deoxy-D-glucose, two-amidine urea benzene, sodium Cefonicid, Cefonicid intermediates, ester Cefamandole sodium, Cefalotin acid, intermediates cefpirome, cefepime sulphate, cefepime intermediate nucleus of cefepime, cefpirome nucleus, Cefamandole sodium, ceftriaxone new active ester, oxaliplatin, cyclophosphamide vary gland amines, polyene match him.

我公司供应的原料药及相关中间体为：二丁酰环磷腺苷钙、伏立康唑、盐酸特比萘芬、维库溴胺、环磷腺苷、甲砜霉素、盐酸甲氯酚酯、卡络磺钠、磷酸替米考星、膦甲酸钠、氯诺昔康、替米考星、头孢匹胺酸、头孢噻呋盐酸盐、头孢噻呋钠、奥扎格雷、盐酸恩丹西酮、羟基脲、替卡西林钠、替米沙坦、盐酸艾司洛尔、盐酸大观霉素、阿德福韦酯、盐酸丁咯地尔、盐酸格拉司琼、华法林钠、甲磺酸加贝酯、尼麦角林、泮托拉唑钠、普拉洛芬、替加氟、盐酸头孢吡肟、维库溴铵、盐酸甲氯芬酯、盐酸舍曲林、头孢尼西胺盐、氨曲南、替卡西林、头孢地尼、头孢地嗪钠、阿魏酸钠、胶体果胶泌、2，3-环戊烯并吡啶、哌拉西林酸、头孢他美酸、头孢甲肟盐酸盐、3-TZ、2-脱氧-D-葡萄糖、双脒苯脲、头孢尼西钠、头孢尼西中间体、头孢孟多酯钠、头孢噻吩酸、头孢匹罗中间体、头孢吡肟硫酸盐、头孢吡肟中间体、头孢吡肟母核、头孢匹罗母核、头孢孟多钠、头孢曲松新型活性酯、奥沙利铂、异环磷腺胺，多烯他赛。

Firstly, 3-ethylthiobutanal was prepared from crotonaldehyde reacting with ethanehiol in triethylamine with high yield. Secondly, methyl acetoacetate was converted to 6-ethylthiohept-3-en-2-one by three steps via hydrolysis, condensation with 3-ethyltio-butanal and dehydration, then 6-ethylthiohept-3-en-2-one was cycloco ndensed with dimethyl malonate by Michael addition and Claisen condensation, followed by saponification and decarboxylation to give the intermediate of 5-(2-ethylthiopropyl)-cyclohexane-1,3-dione.

首先，以巴豆醛与乙硫醇为原料，在三乙胺的催化作用下高收率制得3-乙硫基丁醛；然后从乙酰乙酸甲酯出发，通过碱水解、与3-乙硫基丁醛缩合、脱水三步反应合成6-乙硫基-3-烯-2-庚酮，接着6-乙硫基-3-烯-2-庚酮与丙二酸二甲酯通过Michael加成和Claisen缩合成环，再通过皂化和脱羧反应生成中间体5-[2-丙基]-1，3-环己二酮；再与丙酸酐反应丙酰化，最后与0-3-氯-2-丙烯基羟胺肟化，得到目标化合物烯草酮。

The photocycloaddition of 1-naphthonitrile (1-NpCN) and 2,3-dimethyl-2-butene in cyclohexane or benzene gave cyclobutane 3 primarily,but that of 2-NpCN gave azetine 6 asthe major and cyclobutane 5 as the minor product in low conversion photolysis.

在低转化光解情况下，1-萘甲腈(1-NpCN)和2，3-二甲基丁烯-2在环已烷或苯中的光环加成反应主要得到环丁烷3，但2-NpCN主要得到氮杂环丁烯6和少量的环丁烷5，三氟醋酸量增加抑制1-NpCN和DMB的光环加成反应，表明TFA与基态及单激发态1-NpCN生成非光反应的复合物，它也淬灭(1-NpCN-DMB)激基复合物。

Forbesii, monoterpenes and sesquiterpenes account for 41.30% and 32.65%, respectively, in which (1R)-α-pinene (3.98%), sabinene (2.51%),(1S)-β-pinene (5.78%), m-cymene (4.05%), limonene (3.55%), 3, 7-dimethyl-1, 3, 7-octatriene (3.98%),γ-terpinene (8.70%), anisole (1.78%) and (1S)-endo-bornyl acetate (2.62%) as the monoterpenes and its derivatives, and-β-elemene (1.17%),α-bulnesene (1.40%),-β-bisabolene (1.21%),-elemol (1.42%), guaiol (1.14%), dehydroxyisocalamendiol (1.13%),-aristolene (1.99%), bulnesol (9.48%),γ-eudesmol (1.77%), guai-1(10)-en-11-ol (1.12%) and α-bisabolol (5.35 %) as the sesquiterpenes and its derivatives are the main components.

1R-α-蒎烯(3·98 %)、桧烯(2·51 %)、(1S)-β-蒎烯(5·78 %)、m-月桂烯(4·05 %)、柠檬烯(3·55 %)、3，7-二甲基-1，3，7-庚三烯(3·98 %)、γ-萜品烯(8·70 %)、茴香醚(1·78 %)和(1S)-桥环醋酸冰片酯(2·62 %)为单萜类化合物及其衍生物中的主要成分；-β-榄香烯(1·17 %)、异愈创木烯(1·40 %)、-β-没药烯(1·21 %)、-榄香醇(1·42 %)、愈创木醇(1·14 %)、去羟基异菖蒲二醇(1·13 %)、-土青木香烯(1·99 %)、异愈创木醇(9·48 %)、γ-桉醇(1·77 %)、愈创木-1(10)-烯-11-醇(1·12 %)和α-没药醇(5·35 %)为倍半萜类化合物及其衍生物中的主要成分。

Enynes with an aryl ring at the alkyne give 2,3,9,9a-tetrahydro-1H-cyclopentanaphthalenes by a 5-exo-dig cyclization followed by a Friedel-Crafts-type ring expansion.

带有芳环的1，6-二烯体和炔作用，并通过5-exo-dig路径环化，再紧接着Friedel-Crafts扩环，可以得到2，3，9，9a-四羟基-1H-环戊二烯并萘。6-endo-dig途径的环化在一些例子中作为副反应被观察到，尽管，这在一些具体的反应中，是作为主反应出现的。

The epoxidation can be performedwell when the concentration of quaternary ammoniumsaltand sodium tungstate is 0.06 mol/L and 0.03 mol/L, respectively.

结果表明，季铵盐和钨酸钠的浓度分别为0.06，0.03 mol/L时的催化效果最佳；α-和β-蒎烯的转化率随着H2O2与蒎烯的量比增大而增大，当H2O2与α-蒎烯和β-蒎烯的量比分别为2.0和1.8时，其转化率均可达到100%；较高的温度不利于环氧化反应的进行，因此，环氧化反应温度需控制在20℃以下。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失