环戊酮

Analysis of the structural-activity relationship reveals that the a-methylene cyclopentanone moity is responsible for the antitumor activity of the diterpenoids tested.

分析其构效关系表明分子结构中的α-亚甲基环戊酮为该类化合物的细胞毒活性中心。

Sixteen target compounds were designed and synthesized, basing on 2--(4-hydroxy-3-methoxybenzylidene)cyclopentanone as the lead compound, all of which are innovative and have not been reported yet.

本文以2--(3-甲氧基-4-羟基苯亚甲基)环戊酮为先导化合物，设计并合成了16个目标化合物，均为未见文献报道的新化合物。

The fluorinated polyamides could be dissolved in strong aprotic solvents and some low boiling point solvents, such as cyclopentanone, to form homogenously solution with solid content higher than 20%.

这一系列聚酰胺材料在极性溶剂或低沸点溶剂如环戊酮中都具有较好的溶解性，可以获得固含量高达20％以上的均相溶液，并在较的低温下固化成膜。

Methods The target compounds were synthesized from cyclopentanone via Stork reaction, Mannich reaction and selective reduction.

方法以环戊酮为起始原料，通过Stork烯胺反应、Mannich反应、选择性还原制备目标化合物；以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性。

When acetone oxime was used as substrates, lower conversion and selectivity were obtained. For cyclopentanone oxime as the substrate, the Beckmann fragmentation was observed.

对于丙酮肟和环戊酮肟，前者重排得到N-甲基乙酰胺的选择性低，后者则不发生Beckmann重排。

Methods The target compounds were synthesized from cyclopentanone via Stork reaction, Mannich condensation, amine exchange and selective reduction. Xylene-induced mice ear edema assay was used to evaluate their anti-inflammatory activity.

以环戊酮为起始原料，通过Stork烯胺反应、Mannich缩合反应、胺交换反应和选择性还原制备目标化合物；以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性。

Methods The target compounds were synthesized from cyclopentanone via Stork reaction, Mannich condensation , amine exchange and selective reduction. Xylene-induced mice ear edema assay was used to evaluate their anti-inflammatory activity.

以环戊酮为起始原料，通过Stork烯胺反应、Mannich缩合反应、胺交换反应和选择性还原制备目标化合物；并以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性。

The types and kinds of medical intermediate compounds thiaphenol series, pyridine series, cyclopentanone derivant etc.

医药中间体（噻酚系列、吡啶系列、环戊酮衍生物等）品种多样，产品质量保证，深受广大客户好评。

Synthesis of Antidote of N-Dichloroacetyl-2-methyl-1-oxa-4-aza-spiro-4.4-nonane BI Hong-mei, ZHANG Jin-yan, LIANG Ying, SHEN Yong (College of Arts and Sciences Heilongjiang August First Reclamation University, Daqing 163319, Heilongjiang, China) Abstract: N-Dichloroacetyl-2-methyl-1-oxa-4-aza-spiro-4.4-nonane was synthesized by one pot method with isopropanolamine, cyclopentanone and dichloroacetyl chloride. The optimum reaction conditions obtained are as follows:the proportion in moles of the above materials is 1∶1∶1.2, reaction solvent is toluene, reaction temperature is -15 to -10 ℃,reaction time is 3 h, under the optimum condition, the yield of the compound is 50.0%.

除草剂解毒剂N-二氯乙酰基-2-甲基-1-氧杂-4-氮杂-螺[4.4]壬烷的合成毕洪梅，张金艳，梁英，沈勇(黑龙江八一农垦大学文理学院，黑龙江大庆 163319)摘要：以33%的氢氧化钠水溶液为缚酸剂，异丙醇胺、环戊酮和二氯乙酰氯为原料，采用&一锅法&合成了N-二氯乙酰基-2-甲基-1-氧杂-4-氮杂-螺[4.4]壬烷，采用正交实验法得到最佳反应条件：反应原料摩尔比为1∶1∶1.2，苯作溶剂，反应的温度为-15 ℃~-10 ℃，搅拌时间为3 h，产率达到50.0%。

One of these compounds, 2-diethyl- aminoethyl-5--(4-methoxybenzylidene) cyclo- pentanone hydrochloride (T81) possessed sig- nificant antiinflammatory and analgesic ac- tivity when administered orally.

Ⅲ类化合物完全无抗癌活性，对其中一个化合物2-二乙胺乙基-5--（4-甲氧基苯亚甲基）环戊酮盐酸盐（T81）试验结果表明，它经口给药时具有显著的抗炎、镇痛活性。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失