环戊酮

Mainly engaged in: Hydrogen-imide hydrochloride, o-chlorophenyl cyclopentanone, 3.4 dimethoxy ethyl benzene, butyn single potassium acid, potassium ethyl malonyl, Ding amide, amide isobutyraldehyde , allyl chloroacetate, isopropyl chloroacetate Benzyl aluminum, cyclopentene, cyanide-o-chlorophenyl, o-methyl chloride, sulfuric acid chloride, p-chlorophenol, imidazole, Pinacolone, one chlorine Pinacolone.

主要经营：盐酸氢亚胺、邻氯苯基环戊酮、3.4二甲氧基苯乙酯、丁炔二酸单钾盐、丙二酸单乙酯钾盐、丁酰胺、异丁酰胺、氯乙酸烯丙酯、氯乙酸苄酯异丙醇铝、环戊烯、邻氯苯氰、邻氯苯甲酯氯、硫酸氯、对氯苯酚、咪唑、频呐酮、一氯频呐酮。

The facts that type I compounds could easily undergo deamination reaction to form α-methylene cyclopentanone derivatives and they could react with glutathione to form an adduct provided sufficient evidence for the hypothesis that the compounds acted as masked α-methylenecyclopen- tanones and reacted with biologically important sulfhydry-containing enzymes, and thus produced anticancer activity.

Ⅰ类化合物在稀溶液中极易进行去胺基化反应形成α-亚甲基环戊酮类化合物。并且Ⅰ类化合物于稀溶液中易与谷胱苷肽进行结合，这些事实为Ⅰ类化合物作为隐蔽的α-亚甲基环戊酮与酶进行加成，从而导致酶失活而具有抗癌活性的设想提供了证据。

Accord- ing to the observation that the compounds were stable in low pH aqueous solution and their sta- bility decreased when pH increased, and they rapidly decomposed to form α-methylenecyclopen- tanones derivative when pH reached 6 to 7, we postulated that the compounds were unabsorbable in stomack (where pH1-3) and unstable in small intestine (where pH5-8). The decomposed product was indeed inactive.

对Ⅰ类化合物在稀溶液中的稳定性研究表明，低pH时化合物较稳定，随着pH值的升高稳定性逐渐降低，pH6~7时，化合物迅速分解成α-亚甲基环戊酮类化合物，由此而推测Ⅰ类化合物经口给药无效的原因为：它们在强酸性的胃中（pH1-3）呈离子状态，因而不易吸收，经胃的排空运动进入肠道后，随着pH逐渐升高（pH5-8）化合物迅速分解，而分解产物α-亚甲基环戊酮类化合物证明是无效的。

The observation that 2-Alkylidene or Benzylidene cyclopentanones had little anticancer activity and 2-dimethylaminomethylcyclopentanone hydro- chloride (T59) had low anticancer activity proved that the existance of α,β-unsaturated carbonyl group could enhance the anticancer activity of cyclopentanone Mannich bases.

2-亚烷基、苯亚甲基环戊酮无抗癌活性，2-二甲胺甲基环戊酮盐酸盐（T59）抗癌活性较低，这些事实说明Ⅰ类化合物中的环外不饱和双键是一个增效基团，它的存在能明显增强环戊酮Mannich碱的抗癌活性。

Five types of compounds were synthesized via modification of the leading compounds, Mannich bases of cyclopentanones. Among the target compounds, one type was aromatic amine derivatives of a leading compound, three were Mannich bases of a - benzylidene cyclopentanone, the fifth was a Mannich base of a - benzyl cyclopentanone.

以具有抗炎活性的环戊酮Mannich碱为先导化合物进行结构改造，设计合成了一类已知化合物的芳胺Mannich碱衍生物，三类α-苯亚甲基环戊酮Mannich碱类化合物，一类α-苄基环戊酮Mannich碱类化合物。22个目标化合物的结构经核磁共振氢谱、红外光谱和质谱检测确证。

It has been reported that some natural compounds containing α- methylene-γ-butyrolactone,α-methylenecyclopentanone,α- methylenecyclohexanone,α,β-unsaturated cyclic ketone moiety possessed significant antitumour activity and antiinflammatory activity as well.

在众多的天然产物中，一些含有α-亚甲基-γ-丁内酯，α-亚甲基环戊酮，α-亚甲基环己酮，α，β-不饱和环酮结构的天然化合物具有显著的抗癌、抗炎活性。

The related reaction conditions and factors such as catalysis of some catalysts etc were discussed. In the procedures, 2-pentylidene cyclopentanone intermediate, which could be isomerizated into a 2-pentyl cyclopentenone under acidic conditions, was effectively prepared in the presence of a phase transfer promotor.

讨论了正戊醛和环戊酮在碱性条件下缩合生成2-亚戊基环戊酮的反应温度、碱浓度、相转移催化剂等因素对反应的影响。2-亚戊基环戊酮中间体化合物能在酸催化剂作用下，异构成2-戊基环戊烯酮，其中酸浓度和溶剂等参数对反应影响明显。

Starain LHG1 could not only utilize the intermediate products of cycloalkanes－clohexanone and cyclopentanone, but also could degrade alkane, aromatic hydrocarbon and phenols, such as liquid paraffin,solid paraffin, naphthalene and phenol.

LHG1菌株能够利用环烷烃代谢的中间产物环己酮和环戊酮。此外，LHG1菌株还能降解液体石蜡、固体石蜡、萘和苯酚等链烃、芳香烃和酚类。

A synthesis of 2-pentylidene cyclopentanone starting from cyclopentanone and n-valeraldehyde through aldol condensation, followed by dehydration, was studied, and the yield reached 85.6%. 2-Pentenyl cyclopentanone was prepared in a yield of 95.0% from 2-pentylidene cyclopentanone with a hydrogenation methodology. Through Baeyer-villiger oxidation,δ-decalactone was synthesized in a yield of 63.9% from 2-pentenyl cyclopentanone with hydrogen peroxide.

研究了以正戊醛和环戊酮为起始原料，经羟醛缩合、脱水反应合成2-戊叉环戊酮，产率达到85.6%，2-戊叉环戊酮加氢制备2-戊基环戊酮，产率为95.0%，2-戊基环戊酮在双氧水作用下经Baeyer-villiger氧化重排反应合成δ-癸内酯，反应产率为63.9%，合成δ-癸内酯的总产率为52.0%，气相色谱分析纯度为98.7%。

The fact that the compound, 2-methyl-2-di- methylaminomethyl-5--n-pentylidenecyclo- pentanone hydrochloride (T60) possessed little anticancer activity indicated that the Mannich bases that could formed a methylene group were necessary for anticancer activity.

当环戊酮环上的Mannich碱侧链位置上引入取代基时，抗癌活性显著降低，如化合物2-甲基-2-二甲胺甲基-5--亚戊基环戊酮盐酸盐（T60）几乎无抗癌活性。这说明Mannich碱能形成亚甲基是这类化合物产生抗癌活性所必不可少的条件。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失