环

The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

Methods: from prepation of crude drug as start, study the technology of extract and defat with L9 (3~4) orthogonal test. With EtOH extraction and water sed, alkali washing, EtOAC extraction as main methods of eliminate dopant. Finally with alky AlzO3 chromatographic column, rich and gain anticancer active site. The maximum response was achieved at a 40 min extracting time with 10 times volume 90% EtOH added to the sample for the first time and 30 min for the second time. Adding 10 times water will produce precipitation; Place the precipitation into 6 times petroleum benzin to de-fat at 60℃.

云南红豆杉中抗癌活性物制备工艺研究方法：利用正交设计试验L9(3~4)确定原料药提取工艺为：10倍量90％乙醇提取两次，第一次40分钟，第二次30分钟；醇提液用10倍量水沉；沉淀加6倍量石油醚40℃脱脂；用1mol／L的NaOH溶液碱洗，除去酸性杂质；以碱性氧化铝柱，以环己烷／丙酮为洗脱溶剂，在环己烷-丙酮(6：4)段富集到所需活性部位，洗脱剂用量为3VB。

In this study enamine was used as the reactive intermediate for alkylation of cyclohexanone alkylate,to provide a new route to synthesize the perfume-α-tert-butylcyclohexanone after overcoming many disadvantages of the traditional technical route,such as the complicated of reaction steps,the expensive reagents adopted,the high demand for the equipment used,and the low yield of product.

利用烯胺作为环己酮烷基化的活性中间体，为香料α-叔丁基环己酮的合成提供了一条新的途径，克服了传统工艺反应步骤烦琐，试剂昂贵，设备要求较高，产率不高等缺点，易于工业化生产。

Firstly, one of the two key intermediates, tetrahydrofuran fragment with aterminal alkyne 27, was prepared from D-glucose utilizing a multiple-step sequencedeveloped by us earlier.

在本组过去的工作基础上，我们从葡萄糖出发，获得了含有四氢呋喃环的炔化合物27。同时，从木糖及炔丙醇出发，获得了一端为γ内酯环的烯基碘化合物14，即C1-C13片断。

Major conclutions from this study can be summarized as following:1. On mineralogy, rutiles, apatites, epidotes and vein minerals from UHPM rocks were firstly and systematically studied, by detailed petrography and mineral-chemistry investigation, some mineral or mineral assemblage with special composions or texture were firstly found in UHPM rocks from Sulu-Dabie, for example, corrudum, magnesite, high-Ti biotite and garnet were found as inclusions in rutiles from eclogites, Nb-Fe rutile and zoned Si-Y apatite were found in gneiss, epidote / allanite with euhedral zones like magmatic genesis were found in elogites and gneiss, a lot of minerals with high REE, HFSE, LILE and volatiles were found in veins of gneiss.

在矿物学方面，首次较为系统地研究了超高压变质岩中的金红石、磷灰石、绿帘石等副矿物，并通过详细的岩相学和矿物化学研究，首次在苏鲁-大别超高压变质岩中发现了一些具有特殊成分/结构的矿物或矿物组合，如在榴辉岩金红石中发现了刚玉、菱镁矿、高钛黑云母和石榴石矿物包裹体，在片麻岩中发现了Nb-Fe金红石和具有自形环带结构的高Si-Y磷灰石，在榴辉岩和片麻岩中发现了具有类似岩浆成因的自形生长环带结构的绿帘石/褐帘石，在片麻岩的脉体中发现了大量富含稀土元素REE、高场强元素HFSE(Nb、Ta、Zr、Ti)、大离子亲石元素LILE(K、Th、U、Sr、Ba)，以及挥发性组份(CO_2、F、P、S)的特殊矿物，丰富并提升了超高压变质岩的矿物学研究。2。

Carboxylic acid was peroxidized in organic solvents catalyzed by lipase and glycidol was synthesized from allyl alcohol catalyzed by acid peroxide.

利用脂肪酶在有机介质中催化制备过氧酸，丙烯醇在过氧酸的作用下发生环氧化反应生成环氧丙醇。

In the first part, we studied the possibility of allyl as the protection group of the hydroxyl in nucleosides.

烯丙基作为糖化学中的一种常用保护基在核酸化学中有一定的应用，曾有人将它作为磷酸酯键及碱基环上羰基的保护基，但作为核苷糖环羟基的保护基还未有研究。

Cyclohexene was synthesized by dehydration of cyclohexanol with anhydrous aluminum chloride as catalyst.

以无水三氯化铝作催化剂，对环己醇脱水制备环己烯的反应进行研究。

Review articles only; calretinin; fovea centralis; macula lutea; ora serrata; photoreceptors; rods; cones; optic tract; optic nerve; visual cortex; color vision; photoreception; opsin; rhodopsin; guanine nucleotide-binding protein; G protein-coupled receptors; ion channels (cyclic GMP-gated); guanylate cyclase; cyclic GMP; dark adaptation; visual pigments; polyenes; 11-cis-retinal; vitamin A; chromophores; arrestin; recoverin; phosducin; transducin; bipolar cells; retinal ganglion cells; retinal progenitor cells; amacrine cells; Mueller cells; light; retinogenesis; ommatidia; optic vesicles; retinitis pigmentosa; blindness; macular degeneration; blind spot; Mach bands; electroretinograms; binocular vision; visual acuity; vision; retina

唯一综述；钙网膜蛋白；中央凹；黄斑；锯齿缘；光感受器；杆状细胞；圆锥细胞；视束；视神经；直观皮层；色视觉；光感受；视蛋白；视紫质；鸟苷酸-结合蛋白；G蛋白-电偶受体；离子通道；鸟苷酸环化酶；环鸟苷酸；暗适应；视色素；多烯；11 - cis -视网膜；抗干眼醇；发色团；抑制蛋白；恢复蛋白；phosducin；转导蛋白；双极细胞；视网膜神经节细胞；视网膜祖细胞；无长突细胞；米勒细胞；光；retinogenesis；小眼；视泡；色素性视网膜炎；盲的黄斑变性；盲点；马赫带；视网膜电流图；双目视觉

Calretinin; fovea centralis; macula lutea; ora serrata; photoreceptors; rods; cones; optic tract; optic nerve; visual cortex; color vision; photoreception; opsin; rhodopsin; guanine nucleotide-binding protein; G protein-coupled receptors; ion channels (cyclic GMP-gated); guanylate cyclase; cyclic GMP; dark adaptation; visual pigments; polyenes; 11-cis-retinal; vitamin A; chromophores; arrestin; recoverin; phosducin; transducin; bipolar cells; retinal ganglion cells; retinal progenitor cells; amacrine cells; Mueller cells; light; retinogenesis; ommatidia; optic vesicles; retinitis pigmentosa; blindness; macular degeneration; blind spot; Mach bands; electroretinograms; binocular vision; visual acuity; vision; retina

光感受；视蛋白；视紫质；鸟苷酸-结合蛋白；G蛋白-电偶受体；离子通道；鸟苷酸环化酶；环鸟苷酸；暗适应；视色素；多烯；11 - cis -视网膜的；抗干眼醇；发色团；抑制蛋白；恢复蛋白；phosducin；转导蛋白；双极细胞；视网膜神经节细胞；视网膜祖细胞；无长突细胞；米勒细胞；光；retinogenesis；小眼；视泡；色素性视网膜炎；盲的；黄斑变性；盲点；马赫带；视网膜电流图；双目视觉；视敏度；视觉；视网膜

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。