环

Provided herein is a compound having the formula I R2 is typically a tertiary nitrogen atom, being either alkyl-substituted or member of q heterocyclic ring R7 is typically a monocyclic or bicyclic aromatic ring or a heterocyclic ring wherein said compounds are useful for the treatment of psychiatric disorders including but not limited to depression, generalized anxiety, eating disorders, dementia, panic disorder, and sleep disorders.

本发明提供具有式的化合物(R 2 通常为叔氮原子，其或者为烷基取代或为杂环的成员；R 7 通常为单环或双环芳环或杂环)，其中所述化合物用于治疗精神病学的疾病，其包括抑郁症、泛化性焦虑症、饮食障碍、痴呆症、恐慌病和睡眠障碍。

The conjugated rings affect the bioactivity most. Antitumor activity was greatly improved through changing the phenyl ring with a naphthyl ring.

下端共轭环对活性的影响最大，将下端的共轭环扩大的过程中，将苯环改为萘环，其活性提高了近一个数量级。

The transfer of R group from XZnR occurrs from the same face as the oxygen of epoxide and results in a syn addition since organozinc reagents XZnR could act as a Lewis acid system as well as being nucleophilic in character.

我们制备一类新型有机锌试剂，研究它们在适宜的反应条件下，直接对环氧化合物进行开环反应，得到顺式开环产物，实现了有机金属试剂的立体选择性顺式开环。

It have been observed that oxonium ion reacted with water more easily than with THF. So water could be used as ceasing reagent to control the molecular weight of the polymer.

本文还对四氢呋喃、环氧丁烷和环氧乙烷阳离子开环聚合反应中，分子内尾咬、扩环这一典型的副反应进行了理论研究。

Mol〓. As the result, some sensitizers have obviously sensitive effect, the ratio of / in photostationary state was change, We designed two methods, One of them is that isomers were synthesized, then we obtained the mixtures of isomers via photoisomerization.

本论文试图由两种方法获得-O-烃基-α-氧代环十二酮肟，一种是由体的肟通过化学合成得到体的O-烃基-α-氧代环十二酮肟，再通过光化学反应得到其体；另一种是由-α-氧代环十二酮肟，通过光化学异构合成体，再由体肟化学合成得到-O-烃基-α-氧代环十二酮肟。

The synthetic route starts from penicillin G, peroxyacetic acid(8.5%) as Oxidizing Agent to get penicillin G sulfoxide; esterifided with p-nitrobenzyl bromine to synthesize penicillin G sulfoxide ester; we synthesize 3-exomethylenecepham sulfoxide ester with phthalimide potassium and 4A molecular sieve as acid scavenger to open the ring, SnCl_4 as catalyzation to close the ring. The yield is over 60%.

本研究采用的合成路线为：以青霉素G钾盐为原料，选用工业过氧化氢制备的过氧乙酸(22.3%)稀释至8.5%为氧化剂，氧化得青霉素亚砜；采用对硝基溴苄为酯化试剂，制备青霉素亚砜酯；以NCP(N-氯代邻苯二甲酰亚胺)为开环试剂，酞酰亚胺钾和4A型分子筛为酸清除剂，顺利开环；再经无水SnCl_4催化闭环得3-环外亚甲基头孢亚砜酯，最终产率在60%以上。

Then the cyclocarbonylation of propargylic alcohols under the catalysis of Pd 〓 with CuBr〓 and BQ was studied. Due to the high activity the yields of -α-bromoalkylidene-β-lactones were lower than that of -α-chloroalkylidene-β-lactones while the coupling reaction of -α-bromoalkylidene-β-1actones (i. e. Sonogashira and Suzuki coupling reaction) was quite smooth to afford the products in high yields.

接着我们研究了炔丙醇在Pd〓-CuBr〓-BQ催化体系下的羰基插入环化反应，由于-α-溴代亚烷基-β-内酯环化合物的活性高于-α-氯代亚烷基-β-内酯环化合物，导致反应收率偏低，而同样基于此原因，-α-溴代亚烷基-β-内酯环化合物的偶联反应进行得很顺利，而且收率很高。

We have concluded five key tectonics geologic characteristics of Chinese foreland basins based on the study of the sedimentary infill, tectonics evolution, tectonic dynamics, spatial location distribution and structural deformation geometry.(1) The foreland basin is the superimposition of the compression sedimentary stratigraphic sequence with the extension basin, and the foreland basin includes underlying rift basin and upper dustpan flexure deposited basin.(2) The foreland thrustfold structural deformation has occurred four times since the Protozoic, in the Late Caledonian, Late Hercynian, Indosinan and Late Himalayan, respectively.(3) The foreland basin developed based on the control of two factors that are the basin basement collaged by many small plates or terrains and the rejuvenation of ancient orogenic belt, so the foreland basins or foreland thrusts are located in front of ancient orogenic belt.(4) The foreland basins and the rejuvenation of ancient orogenic belt make up a giant basinmountains system resulting from the distant effect of IndiaEurasia collision, which is located on the outer circle of Tibet Plateau, so the thrust deformation intensity, basin deposition range and coupling between orogenic belt and basin changed from strong to weak as from interior to outer circle of Tibet Plateau.(5) There are many structural styles of the thrust and fold belt in different basins, such as brittle behavior faultrelated fold, ductile behavior basementinvolved structure, basementinvolved faultrelated fold, and salt structure.

在综述前人认识的基础上，笔者通过对中国前陆盆地的构造演化历程、沉积充填特征、构造成因及其空间分布规律、构造变形特征等的研究，提出了中国前陆盆地构造地质发育的5个主要特征：(1)两种不同性质的原型盆地发生正反转的叠合性，即挤压构造下作为&本体&的前陆层序与拉张构造下作为&基础&的裂谷、断陷盆地之间的叠置；(2)显生宙以来中国大陆先后发生了4期前陆冲断构造演化的多期性，它们分别是加里东晚期、海西晚期、印支期和喜马拉雅晚期；(3)基于小克拉通基底拼贴后在造山带前缘复活再生的继承性，即统一拼合大陆内部的构造变形导致古造山带的复活，在古造山带边缘发育新生代前陆盆地或前陆冲断带；(4)在空间分布上受环青藏高原巨型盆山体系控制发生陆内变形的系统性，在环青藏高原巨型盆山体系内构造变形强度、盆地沉降幅度、盆山耦合程度等从内环向外环依次降低，从古造山带向克拉通方向构造变形强度依次降低，构造变形样式逐渐简单、构造变形时间依次变新；(5)前陆冲断带的构造样式由于受边界力学条件和沉积地层介质作用而具有多变性，存在沉积盖层内脆性变形的断层相关褶皱、造山带前缘韧性变形的基底卷入构造、与走滑构造相伴生的基底卷入的断层相关褶皱、盆地内部塑性变形的盐构造。

In order to search for the new pyrazolyl-heterocycles lead compounds, eight pyrazolyl- were synthesized from 3-ethyl-1-methyl- 4-substituted-5-pyrazolecarboxylic acid chloride and nitrogen heterocyclic rings such as 3-methyl-5-pyrazolone, 1H-3-ethyl-5-pyrazole ester, etc.

为了寻求新的含吡唑双杂环先导化合物，用 4 取代 1 甲基 3 乙基 5 吡唑甲酰氯与 3 甲基 5 吡唑酮、3 乙基 5 吡唑甲酸乙酯等含氮杂环反应得到了 8个新的含吡唑环的双杂环类化合物。

Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

本发明涉及含有连接在5元杂环上的稠合至环烷基或者杂环的苯基或者吡啶基环的二环化合物，包括其药学上可接受的盐和前药，它们是G蛋白偶联受体40(GPR40)激动剂并且可以用作治疗性化合物，特别是在2型糖尿病和与这些疾病相关的症状中用作治疗性化合物，这些症状包括肥胖病和脂质疾病，比如混合或者糖尿病型血脂异常症、血脂质过多、高胆甾醇血和高甘油三酯血症。

Shop assistant: Please check at the door.

店员：请您到门口柜台交费。

In the end, transportation of PAHs in the environmental matrix was preliminarily investigated and discussed according to PAHs data of soils and sediments from a certain region in Shanghai. The result indicated that there are two or more pathways on PAHs transportation in the environmental matrix.

最后，对上海特定地区内PAHs在环境介质中的迁移径途进行了分析讨论，结果表明上海市土壤和沉积物等环境介质中PAHs的迁移存在多种途径。