环

Methods:To measure abnormal T vector deviation and morphology as well as QT dispersion in 87 patients compared with control group of 50 patients.

87例原发性T环异常患者分为2组，T环方位异常组50例，T环形态异常组37例，50例T环完全正常者作为对照组，对各组进行了心电测量和心向量分析，并比较了各组的QTd。

Whereas the history of the silent film could be summarized as the discovery of the different means of roducing an evocative succession of visual images, the history of the sound film is the discovery of the different means of producing an vocative integration of visual images and sound.

如果说，无声电影的历史可以概括为产生了一环套一环的视觉形象，那么有声电影的历史是产生一环套一环的视觉形象与声音的结合的种种不同的方式。

Started from D-tyrosine, we obtained the tetramic acid 96 using Jouin reaction. The assembly of the second fragment 109 was stared from 1,4-butandiol,using asymmetric alkylation reaction developed by Oppolzer as a key step. Coupling of the tetramic acid 96 with 109 provided the key intermediate 110 according to Yoshii\'s procedure. After remove protective group and Sharpless epoxidation, we obtained the key intermediate 113. Its macrocyclization to form the final product is in progress.

本论文的第二章主要对Macrocidin A开展了合成工作，我们从D构型的酪氨酸出发，经过官能团转换；利用Jouin反应生成Tetramic acid 96，另外一个片断从1，4-丁二醇开始经过多步反应生成碘化物104，利用Oppolzer发展的手性樟脑磺酰胺为辅基参与的不对称烷基化反应，引入手性甲基，生成关键中间体109，接着通过Yoshii发展的方法连接96和109生成110，经过Sharpless不对称环氧化反应建立环氧化合物，然后脱去保护基得到关环前体113，分子内的Mitsunobu反应进行关大环反应正在进行之中。

While all the phenyl groups in tetraphenylphenyl groups or benzophenanthrene groups are not coplanar. At the same time, by density function theory, the electronic energy gap between HOMO and LUMO frontier molecular orbitals of condensed aromatics are calculated and the Eg of acenaphthenyl groups in C_2 gum is the smallest, which explains the reason why C_2 gum has the best radiation protection effects.

利用甲基三氯硅烷和溴苯的格氏反应合成了甲基苯基二氯硅烷，用核磁分析证实了格氏反应中高沸点副产物为甲基二苯基氯硅烷；通过甲基苯基二氯硅烷和二甲基二氯硅烷的共水解，再裂解而制得含Me_2SiO链节的甲基苯基环硅氧烷混合物，进而利用碱胶开环聚合得到甲基苯基硅橡胶生胶；也可通过甲基苯基二氯硅烷水解所得甲基苯基环硅氧烷D_3~(3Ph、D_4~(4Ph_)与D_4开环聚合制得甲基苯基硅橡胶生胶。

The observation that 2-Alkylidene or Benzylidene cyclopentanones had little anticancer activity and 2-dimethylaminomethylcyclopentanone hydro- chloride (T59) had low anticancer activity proved that the existance of α,β-unsaturated carbonyl group could enhance the anticancer activity of cyclopentanone Mannich bases.

2-亚烷基、苯亚甲基环戊酮无抗癌活性，2-二甲胺甲基环戊酮盐酸盐（T59）抗癌活性较低，这些事实说明Ⅰ类化合物中的环外不饱和双键是一个增效基团，它的存在能明显增强环戊酮Mannich碱的抗癌活性。

Our company supply raw materials and related intermediates as follows: Second dibutyryl cAMP calcium, voriconazole, terbinafine, vecuronium amines, cAMP, thiamphenicol, a chlorophenol hydrochloride esters, card network sodium phosphate tilmicosin, foscarnet, lornoxicam, Tilmicosin, Cephalosporium aspirin acid, ceftiofur hydrochloride, ceftiofur sodium, Ozagrel, ondansetron hydrochloride ketones, hydroxyurea, ticarcillin sodium, telmisartan, esmolol hydrochloride, hydrochloric acid Daguan Nikkomycin, adefovir dipivoxil, buflomedil hydrochloride, granisetron hydrochloride, warfarin sodium,-methyl gabexate acid, nicergoline, pantoprazole sodium,·, tegafur, cefepime hydrochloride, vecuronium bromide, hydrochloric acid meclofenoxate, sertraline hydrochloride, Cefonicid amine salt, aztreonam, ticarcillin, cefdinir, cefodizime sodium, sodium ferulate, colloidal pectin secretion, 2,3 - cyclopentene and pyridine, Piperacillin acid, cefetamet US-acid, hydrochloride Cefmenoxime ,3-TZ, 2 - deoxy-D-glucose, two-amidine urea benzene, sodium Cefonicid, Cefonicid intermediates, ester Cefamandole sodium, Cefalotin acid, intermediates cefpirome, cefepime sulphate, cefepime intermediate nucleus of cefepime, cefpirome nucleus, Cefamandole sodium, ceftriaxone new active ester, oxaliplatin, cyclophosphamide vary gland amines, polyene match him.

我公司供应的原料药及相关中间体为：二丁酰环磷腺苷钙、伏立康唑、盐酸特比萘芬、维库溴胺、环磷腺苷、甲砜霉素、盐酸甲氯酚酯、卡络磺钠、磷酸替米考星、膦甲酸钠、氯诺昔康、替米考星、头孢匹胺酸、头孢噻呋盐酸盐、头孢噻呋钠、奥扎格雷、盐酸恩丹西酮、羟基脲、替卡西林钠、替米沙坦、盐酸艾司洛尔、盐酸大观霉素、阿德福韦酯、盐酸丁咯地尔、盐酸格拉司琼、华法林钠、甲磺酸加贝酯、尼麦角林、泮托拉唑钠、普拉洛芬、替加氟、盐酸头孢吡肟、维库溴铵、盐酸甲氯芬酯、盐酸舍曲林、头孢尼西胺盐、氨曲南、替卡西林、头孢地尼、头孢地嗪钠、阿魏酸钠、胶体果胶泌、2，3-环戊烯并吡啶、哌拉西林酸、头孢他美酸、头孢甲肟盐酸盐、3-TZ、2-脱氧-D-葡萄糖、双脒苯脲、头孢尼西钠、头孢尼西中间体、头孢孟多酯钠、头孢噻吩酸、头孢匹罗中间体、头孢吡肟硫酸盐、头孢吡肟中间体、头孢吡肟母核、头孢匹罗母核、头孢孟多钠、头孢曲松新型活性酯、奥沙利铂、异环磷腺胺，多烯他赛。

A series of 2-oxocyclododecyl sulfonylurea s have been synthesized from 2-oxocyclododecylsulfonamide via acylation of phenyl chloroformate and amination.

以环十二酮为起始原料，经磺化反应制备得到2-氧代环十二烷基磺酸盐B，B经过氯化和胺解反应制备得到2-氧代环十二烷基磺酰胺C，C经过苯氧酰化与胺解反应后合成了10个新的2-氧代环十二烷基磺酰脲类化合物D，它们的结构通过了1HNMR和IR的确证。

The main characteristics include: the quiet Sun corona has a rapid response to the flare heating, within 2 second the corona temperature increases nearly one order of magnitude, but later such increase becomes very slowly; the downward velocity at early stage of impulsive phase is too small to be negnected; chromospheric evaporation made by conduction shows some intensely, the maximum evaporated velocity may be as large as 1000 km/s; the chromospheric condensation appears just when the chromospheric evaporation takes place and its place always coincide with that of transition region in the early stage; the maximum of chromospheric condensation occurs also in the early stage of impulsive phase, at which the density in condensation may be larger two order of magnitude than that of surround and the downward velocity may be as large as 100 km/s; after the maximum of chromospheric condensation, its strongth decreases gradually but its width becomes greater with time and have a tendency to transport into deep chromosphere; the front of chromospheric condensation heats atmosphere obviously and the temperature in the chromospheric condensation is higher than the original case; the downware velocity of transition region may be greater than 100 km/s at the early stage; when the evaporated material collide at the top of loop, the densityand the presure there increase rapidly, which result in the formation of a shock wave; and so on.

在改善色球辐射损失和精确分辨过渡区的基础上，通过联立求解连续性方程、动量方程和能量方程，构造了一维磁限制性耀斑环在热沉积作用下的大气动力学模型，获得了耀斑热模型下脉冲相早期较为细致的大气演化理论图象，其主要特征是：耀斑对宁静日冕的加热相当迅速，仅2秒钟日冕温度增加即达一个量级，之后日冕温度增加缓慢；脉冲相早期日冕向下速度很小，几乎可以忽略，热传导驱动色球蒸发，其过程较为激烈，蒸发极大速度可达到1000km/s；色球压缩区与色球蒸发几乎同时形成，且在早期其位置总是与过渡区位置重合；色球压缩极大发生在脉冲相早期，其时密度可高于周围约2个量级，向下速度可超过100km/s；色球压缩极大后，其强度逐渐减弱，但宽度明显增大，且渐渐脱离过渡区往色球传播；压缩区内物质温度要高于原先的大气温度；过渡区下降在脉冲相早期相当迅速，可超过100km/s；当蒸发物质在环顶高速相碰时，环顶的密度、压力迅速增大，且温度也有所增加，导致形成激波，其波面以每秒上百公里的速度自环顶向下传播；在脉冲相前期，日冕软x辐射对色球的加热作用可以忽略；等。

Priority PAHs recommended by USEPA were all detected, and the mass concentrations of individual PAHs was between 1.49 and 87.43ngg^(-1), The PAHs with low molecular weight, such as Nap, Flu, Ace were observed in relatively low mass concentrations. The PAHs with high molecular weight, such as Chrysene, Indeno [1, 2, 3-cd] pyrene, Benzo perylene were relatively abundant and the mass congcentration of BghiP was the highest. The total mass congcentration of 16 PAHs exceeded standard of Holand from 10 to 40 times, and in middle pollution level comparatively with other districts.

美国环保总署推荐优先控制的16种多环芳烃均被检出，多环芳烃单体的质量浓度在1.49~87.43ngg^(-1)扩之间；其中萘、药、苊等低分子量芳烃的质量浓度相对较低；窟、茚并[1， 2， 3-cd]苝、苯并苝等高分子量芳烃的质量浓度相对较高，苯并苝的质量浓度最高。16种多环芳烃的质量总浓度超过荷兰政府规定无污染土壤PAHs值的10~40倍；与国内外其他地区相比较，多环芳烃污染处于中等水平。

The structure and stability of all possible isomers of C50X(X=SiH2, PH, S) were investigated by ab initio HF/3-21G calculations. The calculation results indicate that the preferred position for cycloaddition of SiH2, PH, and S on C50 is consistent, i.e. on the C3-C4 and C4-C4 sites of C50, and the resultant most stable cycloaddition isomers are [5,6]-closed and [5,5]-closed structures. The main driving force governing the stability of the C50X(X=SiH2, PH, S) isomers is the strain, or the conjugative effect, or the combination of strain and conjugative effect, depending on the addition positions and the types of the attacked C-C bonds.

用从头算HF/3-21G方法研究了C50的环加成衍生物C50X(X=SiH2， PH， S)所有可能的异构体的结构与稳定性，计算结果表明，SiH2基团、PH基团与S原子在C50上环加成的优先加成位置相同，都为C3-C4类键和C4-C4类键，并且相应形成[5，6]-闭环和[5，5]-闭环结构的最稳定异构体；决定C50X(X=SiH2，PH，S)各异构体稳定性的主要因素，因加成位置以及发生加成反应的C-C键的单双键类型的不同，可能是张力、共轭效应或者二者的共同作用。

Shop assistant: Please check at the door.

店员：请您到门口柜台交费。

In the end, transportation of PAHs in the environmental matrix was preliminarily investigated and discussed according to PAHs data of soils and sediments from a certain region in Shanghai. The result indicated that there are two or more pathways on PAHs transportation in the environmental matrix.

最后，对上海特定地区内PAHs在环境介质中的迁移径途进行了分析讨论，结果表明上海市土壤和沉积物等环境介质中PAHs的迁移存在多种途径。