环

This invention provides compounds of Formula; wherein: R is a moiety selected from the group: and n is an integer of 1 or 2; R is selected from hydrogen, amino,-NRR, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, alkynyl of 2 to 12 carbon atoms optionally substituted, halogen, and a 5 to 10 membered heteroaryl ring optionally substituted, having 1 to 4 heteroatoms independently selected from N, O and S; R is selected from hydrogen, alkyl of 1 to 12 carbon atoms optionally substituted, aryl of 6, 10 or 14 carbon atoms optionally substituted, alkenyl of 2 to 12 carbon atoms optionally substituted, vinyl, alkynyl of 2 to 12 carbon atoms optionally substituted and halogen; R is H, alkyl of 1 to 12 carbon atoms optionally substituted, cycloalkyl of 3 to 8 carbon atoms, bicycloalkyl of 5 to 10 carbon atoms or aralkyl optionally substituted; R is OH or -OH; R and R are each independently H or alkyl of 1 to 12 carbon atoms or when optionally taken together with the nitrogen atom to which each is attached form a 3 to 8 membered saturated heterocyclyl ring; R is alkyl of 1 to 12 carbon atoms optionally substituted; or a tautomer or pharmaceutically acceptable salts thereof.

本发明提供式的化合物；其中：R 1 为选自基团和的部分；n为整数1或2；R 2 选自氢、氨基、-NR 6 R 7 、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、具有2到12个碳原子的视情况经取代的炔基、卤素和具有1到4个独立地选自N、O和S的杂原子的视情况经取代的5元到10元杂芳基环；R 3 选自氢、具有1到12个碳原子的视情况经取代的烷基、具有6个、10个或14个碳原子的视情况经取代的芳基、具有2到12个碳原子的视情况经取代的烯基、乙烯基、具有2到12个碳原子的视情况经取代的炔基和卤素；R 4 为H、具有1到12个碳原子的视情况经取代的烷基、具有3到8个碳原子的环烷基、具有5到10个碳原子的双环烷基或视情况经取代的芳烷基；R 5 为OH或-OH 8 ；R 6 和R 7 各自独立地为H或具有1到12个碳原子的烷基，或当视情况与其所连接的氮原子连接在一起时形成3元到8元饱和杂环基环；R 8 为具有1到12个碳原子的视情况经取代的烷基；或其互变异构体或医药学上可接受的盐。

Company business scope: Metric plug plug plug left teeth straight plug, such as Brandt Gauge Metric ring ring ring teeth left straight Brandt ring ring gauge, such as dedicated short taper gauge cone gauge Mohs gauge needle, such as three types of vernier caliper caliper caliper with standard digital calipers, such as depth micrometer caliper micrometer outside diameter micrometer inside diameter micrometer micron micrometer scale, such as lever-type dial indicator dial indicator inner diameter dial indicator digital display dial indicator, such as Square Block-type wide angle square-foot knife-edge knife-edge angle square feet omnipotent point of view, such as meter-type coordinate measuring machine single lever gear comparator block welding inspection regulations, such as foot and other workers?

本公司经营范围：塞规公制塞规左牙塞规直管塞规布氏塞规等环规公制环规左牙环规直管环规布氏环规等专用量规锥度量规短锥量规莫氏量规三针等卡尺类游标卡尺带标卡尺数显卡尺深度卡尺等千分尺外径千分尺内径千分尺内侧千分尺微米千分尺等量表类百分表杠杆百分表内径百分表数显百分表等角尺类宽座角尺刀口尺刀口角尺万能角度尺等量仪类单坐标测量仪杠杆齿轮比较仪焊接检验尺等块规及其他工？

The lower end of the discharge chamber body is in hermetically-threaded connection with a fixed electrode; an operation electrode is mounted at the upper end of the discharge chamber body; the lower end of the operation electrode can be movably mounted in a conduction fixed ring; a fit clearance between the lower end of the operation electrode and the conduction fixed ring is 0.1 to 0.15mm; the conduction fixed ring is in hermetically-threaded connection with the upper end of the discharge chamber body; the conduction fixed ring is connected with a grounding wire; a discharge chamber is formed between the conduction fixed ring and the fixed electrode at the inner part of the discharge chamber body; the upper end of the operation electrode is fixedly connected with an insulation handle.

本发明公开了一种隔爆放电器，包括由防爆有机玻璃制成的筒形放电室本体，所述放电室本体的下端密封螺纹连接有固定电极；所述放电室本体的上端安装操作电极，所述操作电极的下端可移动地安装在导电固定环内，与导电固定环配合间隙为0.1～0.15mm，导电固定环密封螺纹连接在放电室本体的上端，导电固定环上连接有接地线；在放电室本体的内部导电固定环和固定电极之间形成放电室，所述操作电极的上端固接绝缘手柄。

The group disposed by Acetylspiramycin doesn"t show parallel results; The strip gray scale of exotoxin A decreased gradually with the increasing dosages of Azithromycin and Roxithromycin, which doesn"t show in group disposed by Acetylspiramycin and group PAO-JP2; The strip gray scale of lasR, detected by RT-PCR, decreased gradually with the increasing dosages of Azithromycin, which doesnt show in group PAO-JP2.Conclusions: There were obvious differences between PAO1 and PAO-JP2 in biology characteristics in vitro.

本研究发现大环内酯类药物在生物被膜培养过程中分别处理PAO1、PAO-JP2，结果提示大环内酯类药物(14、15元环)通过对QS系统的影响可有效抑制铜绿假单胞菌生物被膜的形成；通过QS系统有效抑制铜绿假单胞菌的毒力因子的产生，16元环的大环内酯类药物乙酰螺旋霉未见上述结论；lasR基因的反转录结果提示阿奇霉素可在转录水平抑制QS系统发挥其作用。

In the third chpter, we combine local rings with semiregular rings and strongly π-regular rings, respectively.

我们除了对这两类环的性质作了一定的研究之外，还把一部分局部环和半正则环、强π正则环的结果推广到这两类环上。

Products include a variety of castings and forging, and so on more than 1,000 pieces of products, of which shackle, the first card, blue flowers, wheels, rings, rotating ring, rings, screws, nuts rings, spring hook, hook-eye, rotating hook, Ring, D-ring, ring fast connection, U-Wire, bollard, hold the door, the living section bolts, butterfly nut products such as stainless steel rigging has been occupied with domestic and international cable industry's fixed market.

产品包括各种铸造件和锻造件等上千余种产品，其中卸扣、卡头、花兰、滑轮、套环、旋转环、吊环螺丝、吊环螺母、弹簧钩、眼型钩、旋转钩、圆环、D型环、快速连接环、U型丝、系船柱、门扣、活节螺栓、蝶型螺母等不锈钢索具产品已占领国内外索具行业的固定市场。

We mainly supply all kinds stainless steel rigging of casting and forging, such as :shackle,wire rope clips,turnbuckle,pulley,thimble,swivels,eye bolt,eye nut,spring hook,eye hook,swivel hook,round ring,quick link,U-Bolt,bollard,pad eye,swivel bolt,wing nut ect.

产品包括各种铸造件和锻造件等上千余种产品，其中卸扣、卡头、花兰、滑轮、套环、旋转环、吊环螺丝、吊环螺母、弹簧钩、眼型钩、旋转钩、圆环、D型环、快速连接环、U型丝、系船柱、门扣、活节螺栓、蝶型螺母等不锈钢索具产品已占领国内外索具行业的固定市场。

By introducing the concepts of semiideal and regular semiideal with respect to a given subring, the general power rings and regular power rings are constructed and a number of examples of non-regular HX rings and non-regular power rings are cited.

通过引入了关于一个子环的半理想与正则半理想概念，构造出一般幂环与正则幂环，并具体给出了若干非正则HX环与非正则幂环的例子。

Author had started the research on design and synthesis of heterocycles several years ago, mainly focused on the design and synthesis of imidazole, thiazole, tetrazole derivatives and their glucosides, in which most of them may have some particular bioactivities.

本论文主要是围绕具有生理活性含氮杂环化合物的设计与合成而展开的，在论文工作中我们应用液相"一锅法"和固相组合化学方法进行了咪唑环、噻唑环、四氮唑环等具有生理活性的杂环化合物及其糖苷的合成。

Central Southern China Electric Power Design Institute , Wuhan 430071 , China Abstract : The project of strengthening flawed concrete chimney uses unboundedly prestressed strand hoop.

在钢筋混凝土烟囱裂缝加固工程中采用了无粘结钢绞线预应力环箍，对加固过程进行了现场测试，经预应力环箍加固后的烟囱筒壁中建立的环向压应力在环箍处最大，其值约- 1.0 MPa ，环向压应力衰减较快。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。