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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle,CP)和两个19S调节颗粒(regulatory particle,RP)组成的ATP(adenosine-triphosphate,ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心,它是由4个圆环堆叠形成的桶状复合物,其中两侧外环每个环是由α_1-α_7亚基组成,两个内环每个环是由β_1-β_7亚基组成,4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔,其内壁为催化活性位点所在地;外侧α环中心的孔道是底物到达催化中心空腔的通道,一般被α亚基上的N末端所封闭,阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

Crisp curtains of cheap chintz hung from the tent-bedstead; festooned drapery of the same material shrouded the narrow window, shutting out the light of day, and affording a pleasant harbour for tribes of flies and predatory bands of spiders.

挂在帐篷式床架子上的廉价的印花皱布帐子;用同样的料子制作而成的、饰有花彩的窗帘,遮掩着狭窄的窗子,挡住了日光,为苍蝇和捕食的蜘蛛等族类提供了愉快的托庇之地。

RESULTS: Stent materials play an important role in reducing inflammatory reaction and restenosis following stent implantation. As a medical material for humans, the features of stent should be meet the requirements of reliable distensibility, mechanical persistence, good flexibility and geometrical stability, possible small diameter, excellent blood compatibility, as well as good corrosion resistance. All of these depended on the mechanical and physical features of materials.

结果:支架材料的选择在减少机体炎症反应的强度和持续时间,减少支架置入后血管内再狭窄的发生起着重要的作用,作为人体医用材料,对支架各方面性能都提出了很高的要求,包括可靠的扩张性和力学持久性、良好的柔韧性和几何稳定性、尽可能小的外径,优异的血液相容性和耐蚀性,而支架上述特性都依赖于材料的力学和物理特性。

As a medical material for humans, the features of stent should be meet the requirements of reliable distensibility, mechanical persistence, good flexibility and geometrical stability, possible small diameter, excellent blood compatibility, as well as good corrosion resistance.

结果:支架材料的选择在减少机体炎症反应的强度和持续时间,减少支架置入后血管内再狭窄的发生起着重要的作用,作为人体医用材料,对支架各方面性能都提出了很高的要求,包括可靠的扩张性和力学持久性、良好的柔韧性和几何稳定性、尽可能小的外径,优异的血液相容性和耐蚀性,而支架上述特性都依赖于材料的力学和物理特性。

The competitive risks of focus strategies include (1) a competitor's, tor's ability to use its core competencies to "out focus" the focuser by serving an even more narrowly defined competitive segment,(2) decisions by industry-wide competitors to focus on a customer group's specialized needs, and (3) a reduction in differences of the needs between customers in a narrow competitive segment and the industry-wide market.

竞争风险的战略重点包括:( 1 )竞争对手的, Tor的能力,利用其核心能力"的重点"的focuser的服务更狭义上的竞争力的部分,( 2 )决定全行业的竞争将重点放在客户群的特殊需求,以及( 3 )减少了分歧,需要与客户在一个狭窄的竞争性部分和全行业的市场。

Inflorescences aggregations of sessile florets in spikelets or pseudospikelets, branching absent to compound, bracteate or ebracteate; spikelets prophyllate or not, glumes often poorly distinguished from basal bracts and lemmas, not subtending viable buds or branches, or in pseudospikelets subtending axillary buds capable of partial or extensive spikelet ramification; lodicules absent to very many, usually 3, usually ciliate, veined, posterior lodicule usually narrower than anterior pair.

花序(更多的correctlysynflorescences)集中的无梗小穗或复合的分枝无到,pseudospikelets小花,或无苞片;小穗先出叶与否,从基部的苞片和外稃卓越的不好的颖片通常,通常,许多的鳞被无到,通常具缘毛,,通常比前面对狭窄的后唇瓣鳞被。

I've traveled aboard rigs ranging from a 53-foot "round-bottom" shrimper to a 16-foot Chaland crab boat, eating Cajun red beans and rice and shrimp boulettes cooked in tiny galleys by deckhands along the way. I've floated past old bayou swing bridges activated by hand-guided ropes and steamed out into marshland so vast it stretches beyond the Earth's curvature with flocks of roseate spoonbills dotting the sunset horizon.

我坐过各式各样的船﹐从53英尺的圆底捕虾船到16英尺平底捕蟹船﹔途中吃船员在狭窄的船上厨房做的凯均红豆米饭和虾球﹔我穿过老旧的缓流溪旋桥﹐开启是用绳索﹔我也坐过汽艇﹐进入广阔的沼泽区,一望无际﹐延伸到天边,玫瑰色的篦鹭是落日地平线上点缀的圆点。

As two men, measuring-rods in hand, quarrel about their boundaries in a field that they own in common, and stickle for their rights though they be but in a mere strip, even so did the battlements now serve as a bone of contention, and they beat one another's round shields for their possession.

壮实的鲁基亚人不能捅开达奈人的护墙,打出一条直抵海船的通道,而达奈枪手也无力挡开已经逼至墙根的鲁基亚兵汉,像两个手持量杆的农人,站在公地上,大吵大闹,为决定界石的位置,在一条狭窄的田域,为争得一块等量的份地翻脸,其时,雉培隔开两军,而横越墙头,双方互相杀砍,击打着溜圆的、摭护前胸的牛皮盾面,击打着稳条飘舞的护身的皮张。

With the system, in vivo experiments were performed and the result proved the validity and feasibility of this approach. The result can be presented like this: the mean WSR value of common carotid artery from healthy adults is between 150~350s-1, and the max WSR value is between 450~750s-1; with comparing the WSR value from a male who is suffering from the internal carotid artery straitness with the natural range of WSR, a phenomenon was found that his max and mean WSR value are both smaller than the natural value evidently.

并且利用该系统进行了大量的在体实验研究,得到了相应的结果并验证了该方法的有效性及可行性,该结果显示:健康成年人的颈总动脉的血管壁剪切率平均值范围为150~350s-1,最大值范围为450~750 s-1;将患有颈内动脉狭窄的患者的血管壁剪切率与正常范围比较发现,其血管壁剪切率的最大值及平均值均显著小于正常范围。

Rapids are created when rivers are on a steep gradient, making the water flow very fast, when the flow is constricted into a narrower channel, or where an obstruction such as a boulder interrupts the river, causing eddies and swirling currents.

当河流的坡度陡斜造成水流变快的时候,当水流被挤入更为狭窄的河道的时候,或是在河流被巨石之类的障碍物阻隔从而引起旋涡和涡流的地方,就会形成急流。

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Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时,他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

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世纪伟人邓小平的富民思想,是邓小平经济理论体系中的重要组成部分,是我国经济建设根本任务的一个重要方面。