狭窄的

Results In 84 cases of nerve root type,stenosis was found in 438 intervertebral foramen,of which C6～7 and C5～6 intervertebral foramen stenosis accounted for 79.6%.The causes of intervertebral foramen stenosis were uncinate process articulation hyperosteogeny,intervenebral disc protrusion,vertebral body hypertrophy,zygapophysis hyperosteogeny and dislocation etc.40 cases of vertbral artery type manifested that vertbral artery became slim and deviousness as a result of the compression of vertbral artery （20.7%） by osteophyte.22 cases of myeloid type manifested with cervical spinal canal stenosis,hyperosteogeny of posterior vertebral body edge,posterior longitudinal ligament calcification and cervical intervertebral disc protrusion etc.

结果 84例神经根型中，发现椎间孔狭窄438处，其中C5～6和C6～7椎间孔狭窄占79.6%，椎间孔狭窄的成因有钩突关节骨质增生、椎间盘突出、椎体肥大、小关节突骨质增生、错位等；40例椎动脉型表现为骨赘压迫椎动脉（52.5%），导致椎动脉变细、粗细不均和椎动脉迂曲。22例脊髓型表现为颈椎椎管狭窄、椎体后缘骨质增生、后纵韧带钙化、椎间隙狭窄和颈椎间盘突出等。

The degradating and redistributing of ECM were migration of VSMC and vascular remodeling through inhibiting the production of PDGF-BB and the activation of MMPs so to prevent the vascular stenosis.⑤Orthotopic hybridism in situ: The expression of MMP-3 increased after operation, the tendency and intensity were parallel to the expression of NF-κB. Tongxinluo could decrease the expression of MMP-3 and NF-κB. The study showed that the producting and activating of MMP-3 were modulated by NF-κB. The inhibition to the producting and activating of MMp-3 of Tongxinluo was mediated by inhibiting the activating of NF-κB. Conclusion ①The rabbit vascular stenosis model could be established successfully by plain balloon damage, the operation process was easy, economical and practical.

①单纯球囊损伤可成功建立典型家兔血管狭窄模型，操作方法简单，经济实用；②以VSMC增殖、迁移为主的内膜增厚以及以ECM降解、合成与再分布所致的血管重构是导致受损血管狭窄的根本原因；③通心络能明显抑制VSMC的增殖、迁移和ECM降解、合成，阻止血管内膜增生和血管重构，防止受损血管狭窄；该作用可能与其减少和阻止PDGF-BB的产生和活性，以及抑制MMPs的表达和恢复MMPs/TIMPs平衡有关；④通心络能显著抑制球囊损伤后血管内膜增生和血管重构，可能与其保护血管内皮，改善内皮功能，增加血清NO含量有关；⑤通心络抑制内膜增生和血管重构，减轻受损血管狭窄，还可能是通过抑制NF-κB的活化途径而起作用的。

Abstract］ objective to assess the efficacy and safety of holmium laser urethrotomy under ureteroscope to treat the urethral stricture.methods 16 cases were treated by holmium laser resection under ureteroscope.the length of the stricture was 0.1～1.0 cm.the blood loss and the complications as well as curative effect after operation were observed.results all of the cases were treated successfully with less bleeding and no severe complications.the maximal urinary flow rate improved obviously after operation.conclusion the holmium laser under ureteroscope demonstrates good effect to treat urethral stricture.

目的 探讨输尿管镜下钬激光切开术治疗尿道狭窄的疗效。方法 16例患者采用经尿道输尿管镜下钬激光切开术治疗，狭窄长度0.1～1.0 cm，观察其术中出血、术后并发症及疗效。结果 16例患者均顺利完成手术，疗效满意，术中出血少，术后最大尿流率较术前有明显改善，无严重并发症发生。结论输尿管镜下钬激光切开术治疗对尿道狭窄是一种安全、微创且行之有效的治疗方法。

METHODS 99 cases with isolated RCA stenosis confirmed angiographically were grouped in terms of severity and location of RCA lesions. Their left ventricular ejection fraction, left ventricular end diastolic pressure measured by ventriculography were compared with those of the control group with no significant coronary lesions.

将冠状动脉造影证实为单纯RCA狭窄的患者99例，按不同狭窄程度、不同狭窄节段和不同冠脉优势型进行分组，并与494例无冠状动脉狭窄的对照组比较，经左心室造影测定的左室射血分数和左室舒张末压。

Sensitivity of 64-slice CTA in diagnosis carotid and vertebral arterious stenosis is respectively 97.70%、93.75%, specialty is respectively 99.51%、99.57%.

CTA显示不同程度狭窄的血管段共115段； DSA显示不同程度狭窄的血管段共108段。64层CTA对颈、椎动脉狭窄总的诊断敏感度分别为97.70%、93.75%，特异度分别为99.51%、99.57%。

Various arterious stenosis diagnosed by CTA were 115 segment, DSA 108 segment. Sensitivity of 64-slice CTA in diagnosis carotid and vertebral arterious stenosis is respectively 97.70%、93.75%, specialty is respectively 99.51%、99.57%.

CTA显示不同程度狭窄的血管段共115段； DSA显示不同程度狭窄的血管段共108段。64层CTA对颈、椎动脉狭窄总的诊断敏感度分别为97.70%、93.75%，特异度分别为99.51%、99.57%。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

Results Compared with percutaneous coronary angiography,the sensitivity of sixteen slice sparil CT in diagnosing moderate and severe coronary stenosis was 83.33%,and the specificness,positive predictive value,negative predictive value and degree of accuracy was 91.40%,85.59%,89.95% and 83.33% respectively.

对16层螺旋CT显示冠状动脉狭窄和经皮选择性冠状动脉造影显示冠状动脉狭窄进行定量评价。以经皮选择性冠状动脉造影结果作为诊断的金标准。计算出16层螺旋CT冠状动脉成像对冠状动脉狭窄的诊断准确性指标。

Results The sensitivity and specificity of color ultrasound for stenosis of carotid bifurcation, subclavicular artery and vertebral artery were 96.8%, 80.6%, 60.0% and

结果 本组患者彩色多普勒超声检查对诊断颈动脉分叉部狭窄的敏感性和特异性分别为96.8%和80.6%，对锁骨下动脉狭窄为60.0%和98.7%，对椎动脉狭窄为33.3%和89.0%。

ResultsThe sensitivity and specificity of color ultrasound for stenosis of carotid bifurcation, subclavicular artery and vertebral artery were 96.8%, 80.6%, 60.0% and

结果 本组患者彩色多普勒超声检查对诊断颈动脉分叉部狭窄的敏感性和特异性分别为96.8％和80.6%，对锁骨下动脉狭窄为60.0%和98.7%，对椎动脉狭窄为33.3%和89.0%。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了