狂犬病

Bats have neither lice nor fleas, but they carry more exotic life forms, such as germs associated with Rabies (a strange little animalcule that actually lives in the brains of mammals including humans.—we can imagine therefore that the Rabies germ is closest to art of all life-forms.), Cholera, and Dysentery.

蝙蝠身上既没有虱子也没有跳蚤，但他们带来了更独特的生物，比如狂犬病菌（一种以哺乳动物包括人类的大脑为生存环境的微生物-----我们由此还可以想象这种狂犬病菌比其他任何一种生物都更接近艺术），霍乱和痢疾。

The two isolates were more closely related to CTN, with the homogeny of N gene and G gene as 89.1% and 85.6%-85.7% at the nucleotide level, but 97.6%-98.0% and 92.3% at the amino acid level respectively, than to other vaccine strains.

结论2株狂犬病毒是基因1型狂犬病毒，但无论是N基因还是G基因的核苷酸序列，以及推导出来的氨基酸序列与已知的1型狂犬病毒株及疫苗株均有一定的差异。

The two isolates were more homogeneous with CTN among vaccine strains, and the homogeny of N gene and G gene was 89.1% and 85.6-85.7% in nucleotide level, and 97.6-98% and 92.3% in amino acid level respectively.

目的 分析河南省两株狂犬病毒的遗传学特征，了解狂犬病毒的街毒株与人用及兽用狂犬病疫苗株间的差异，为有效控制狂犬病疫情提供科学依据。

Rabies is a kind of acute infectious disease impacting people's central nervous system caused by hydrophobia virus.

狂犬病是由狂犬病毒引起的急性中枢神经系统的传染病。

To investigate the different effect of combined vaccination with human rabies immunoglobulinand hydrophobia vaccine and independent vaccination with hydrophobia vaccine,and guide the vaccinated work of hydrophobia vaccine.

了解人狂犬病免疫球蛋白与狂犬病疫苗联合接种和单纯接种狂犬病疫苗人群的接种效果的区别，以指导具体的狂犬病疫苗接种工作。

Neutralizing potency of the patent recombinant anti-rabies virus McAbs, SO57 and SOJB,have been investigated broadly to different rabies virus strains in various animal models.100% Chinese Hamsters could be protected by 100IU/kg SO57 against China prevalent street rabies virus named SBD.We firstly established the mouse model to simulate human postexposure prophylaxis by rabies virus and found SO57 had the same function with HRIG against CVS or three China typical street rabies viruses.However,HRIG could not 100% protect the mice challenged with SBD street virus,rabies virus vaccine alone could not save life from rabies virus infection.The cocktail containing SOJB and SO57(1:1) did not do better than SO57 alone.

用不同的动物模型研究了具有专利的重组人抗狂犬病病毒单克隆抗体SO57、SOJB对不同狂犬病病毒株的中和作用，100IU/kg的SO57能100%保护被中国街毒株SBD攻击的中国仓鼠；首次用小鼠模型模拟人体被狂犬病病毒攻击后的治疗情况，在小鼠被CVS及中国街毒代表株攻击后，SO57与HRIG具有相近的对小鼠的暴露后保护作用；同时结果显示HRIG对SBD株攻击的保护率不能到达100%，仅使用疫苗是不能对感染病毒的小鼠百分之百的保护；SOJB与SO57 1：1联合使用未显示比SO57单独使用更好的保护效果。

The number of rabies infections increase these years,because there is no universal investigation in China, so it is unsure about the epidemicsituation of rabies in China. It is essential to study the molecular epidemiology ofstreet rabies virus isolated from the nature in order to prevent rabies infection andunderstand different inquilinous bodies of virus in different areas.

中国自2000年以来狂犬病的流行呈逐年上升的趋势，由于中国尚未开展大面积普遍的狂犬病流行病学调查，所以对中国境内狂犬病的流行情况还不明确，为了有效防制狂犬病，非常有必要对自然界分离的狂犬病街毒进行分子流行病学研究，以了解不同地域不同宿主病毒的流行特点。

It is shown that G gene has the highest speed during the evolution and has uniqueinquilinous body in order to escape immune pressure from inquilinous body byanalyzing phylogenic trees of five genes in the whole genome. In the evolution of Ggene, DRV and MRV are in different groups. DRV, Chinese vaccine isolated used inhuman and Japanese vaccine isolated used in human are in the same group. MRV,CVS and street viruses isolated from dogs are in the some group. It is shown thatDRV is vaccine isolated compared with phylogenic trees of other genes, and it istestified previous conclusion that unqualified vaccine used for human was used nearthe infected beer cote resulted in spotted deer infected.

对狂犬病毒基因组5个基因的分子进化树分析表明，为了逃避宿主的免疫压力，G基因的进化最快速，而且具有宿主的特异性，在G基因的进化中，DRV和MRV分别位于不同的组群，DRV与中国人用疫苗株和日本疫苗株在一个组群，MRV与CVS以及犬脑分离的街毒归在一个组群，结合其他基因的进化树表明，DRV与疫苗株具有较近的亲缘关系，从分子水平验证了以前对DRV流行病学调查得出的推测，在狂犬病疫情发生的鹿场附近曾使用过人用狂犬病疫苗，导致梅花鹿感染狂犬病毒。

Rabies virus, the etiologic agent of fatal neurological disease, is composed of five stuctural proteins, both of the glycoprotein and the nucleoprotein are believed the decisive factors for rabies diagnosis and classification and for rabies neurotropic, pathogenicity and antigenecity.

狂犬病毒由五种结构蛋白组成，其中NP对狂犬病的诊断和分类；GP对狂犬病毒的组织嗜性、致病和免疫保护都起着决定性的作用，并且分离自不同宿主或不同地理位置的狂犬病毒之间存在着NP和GP抗原性差异，研究这种差异并结合流行病学资料有助于发现流行来源的线索。

Objective To investigate the infection rate of the rabies virus in the Chinese Ferret-Badger in Lishui City,and to provide the scientific evidence for the prevention and control of rabies.

目的调查浙江省丽水市狂犬病毒在鼬獾中的感染率，为防制该病提供科学依据。方法收集丽水市狂犬病疫区鼬獾脑组织标本，用DFA和RT-PCR方法分别检测狂犬病毒特异性抗原及核酸，确定阳性标本。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失