特德

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

He succeeded so well that his game of "Contract Bridge" became the staple diet of card players everywhere.

哈罗德·斯特灵·范德比尔特获得了极大的成功，他所创新的"定约桥牌"变成了各地最为流行的牌戏。

While photographing water birds in Florida's Fort DeSoto Park, Doxstater spotted a long-billed curlew hundreds of feet away in the middle of a tidal marsh.

在德索特堡公园拍摄水鸟的时候，德克斯特发现在100英尺之外的潮沼中央有这样一只长嘴的鸟。

Peter Eastgate hit an ace-to-five straight on the turn and instantly called an all-in bet from Ivan Demidov on the river to win the title and $9,152,416. Demidov held two pair, twos and fours.

彼得。伊斯特盖特拿到一副从 A 到5的顺子不失时机的押上自己的全部筹码战胜了手持一对2和一对4的德米德夫夺得冠军和9百多万美金的奖金。

After the flames of war had spread for ten years before the walls of troy, a prophet foretold that troy could never be expected to fall as long as the palladium was treasured by its people .in order to steal it out,odysseus and diomedes slipped into the capital one night in disguise , known to none but hellen.

在特洛伊建成之前，战火已弥漫了十年。一位预言家说：只要雅典娜的神像受人民的爱戴，特洛伊城就永远不会衰灭。为了将神像偷出城，一天夜里奥德修斯和狄俄墨德斯乔装改扮潜入首都，这一切只有海伦知道。

Bloom assented covertly to Stephen's rectification of the anachronism involved in assigning the date of the conversion of the Irish nation to christianity from druidism by Patrick son of Calpornus, son of Potitus, son of Odyssus, sent by pope Celestine I in the year 432 in the reign of Leary to the year 260 or thereabouts in the reign of Cormac MacArt died

布卢姆倒是不动声色地同意了斯蒂芬所指出的爱尔兰国民放弃对德鲁伊特的信仰而皈依基督教的时期在年份上的错误。应把李尔利王统治下，教皇切莱斯廷一世派遣帕特里克（奥德修斯之子波提图斯之子卡尔波努斯之子）前来的公元四三二年，更正为科麦克。

He had sold the last of his furniture, then all duplicates of his bedding,his clothing and his blankets, then his herbariums and prints; but he still retained his most precious books, many of which were of the greatest rarity, among others, Les Quadrins Historiques de la Bible, edition of 1560; La Concordance des Bibles, by Pierre de Besse; Les Marguerites de la Marguerite, of Jean de La Haye, with a dedication to the Queen of Navarre; the book de la Charge et Dignite de l'Ambassadeur, by the Sieur de Villiers Hotman; a Florilegium Rabbinicum of 1644; a Tibullus of 1567, with this magnificent inscription: Venetiis,in aedibus Manutianis; and lastly, a Diogenes Laertius, printed at Lyons in 1644, which contained the famous variant of the manuscript 411, thirteenth century, of the Vatican, and those of the two manuscripts of Venice, 393 and 394, consulted with such fruitful results by Henri Estienne, and all the passages in Doric dialect which are only found in the celebrated manuscript of the twelfth century belonging to the Naples Library.

他把最后的几件木器也卖了，随后，凡属多余的铺盖、衣服、毛毯等物，以及植物标本和木刻图版，也全卖了；但是他还有些极珍贵的藏书，其中有些极为稀有的版本，如一五六○年出版的《历史上的圣经四行诗》，皮埃尔·德·贝斯写的《圣经编年史》，让·德·拉埃写的《漂亮的玛格丽特》，书中印有献给纳瓦尔王后的题词，贵人维里埃－荷特曼写的《使臣的职守和尊严》，一本一六四四年的《拉宾尼诗话》，一本一五六七年迪布尔的作品，上面印有这一卓越的题铭："威尼斯，于曼奴香府"，还有一本一六四四年里昂印的第欧根尼·拉尔修①的作品，在这版本里，有十三世纪梵蒂冈第四一一号手抄本的著名异文以及威尼斯第三九三号和三九四号两种手抄本的著名异文，这些都是经亨利·埃斯蒂安②校阅并取得巨大成绩的，书中并有多利安方言的所有章节，这是只有那不勒斯图书馆十二世纪的驰名手抄本里才有的。

He had sold the last of his furniture, then all duplicates of his bedding,his clothing his blankets, then his herbariums prints; 8ttt8.com he still retained his most precious books, many of which were of the greatest rarity, among others, Les Quadrins Historiques de la Bible, edition of 1560; La Concordance des Bibles, by Pierre de Besse; Les Marguerites de la Marguerite, of Jean de La Haye, with a dedication to the Queen of Navarre; the book de la Charge et Dignite de l'Ambassadeur, by the Sieur de Villiers Hotman; a Florilegium Rabbinicum of 1644; a Tibullus of 1567, with this magnificent inscription: Venetiis,in aedibus Manutianis; lastly, a Diogenes Laertius, printed at Lyons in 1644, which contained the famous variant of the manuscript 411, thirteenth century, of the Vatican, those of the two manuscripts of Venice, 393 394, consulted with such fruitful results by Henri Estienne, all the passages in Doric dialect which are ssbbww.com found in the celebrated manuscript of the twelfth century belonging to the Naples Library.

他把最后的几件木器也卖了，随后，凡属多余的铺盖、衣服、毛毯等物，以及植物标本和木刻图版，也全卖了；但是 dddTt 他还有些极珍贵的藏书，其中有些极为稀有的版本，如一五六○年出版的《历史上的圣经四行诗》，皮埃尔·德·贝斯写的《圣经编年史》，让·德·拉埃写的《漂亮的玛格丽特》，书中印有献给纳瓦尔王后的题词，贵人维里埃－荷特曼写的《使臣的职守和尊严》，一本一六四四年的《拉宾尼诗话》，一本一五六七年迪布尔的作品，上面印有这一卓越的题铭："威尼斯，于曼奴香府"，还有一本一六四四年里昂印的第欧根尼·拉尔修①的作品，在这版本里，有十三世纪梵蒂冈第四一一号手抄本的著名异文以及威尼斯第三九三号和三九四号两种手抄本的著名异文，这些都是经亨利·埃斯蒂安②校阅并取得巨大成绩的，书中并有多利安方言的所有8 tt t8.com 章节，这是只有那不勒斯图书馆十二世纪的驰名手抄本里才有的。

Frost might have encountered this relatively esoteric term in a purely legal context, but there is reason to believe that it came to him from Marlowe's Doctor Faustus, from a passage in which Mephistopheles tells the learned Doctor that he "must bequeath" his soul "solemnly / And write a deed of gift with thine own blood ..."

佛洛斯特可能在纯粹法律的文章中，遇到这个比较古怪的术语。但是我们有理由相信，他在阅读英国作家「马罗」的「浮士德博士」时看到这个术语。有一段，魔鬼梅菲斯特告诉博学的浮士德博士，「他必须尊重其事地放弃他的灵魂，然后用自己的手写下礼物的契约。

He reflected that had he not given his five francs to the Jondrette girl in the morning,he would have followed M. Leblanc's fiacre, and consequently have remained ignorant of everything, and that there would have been no obstacle to the trap of the Jondrettes and that M. Leblanc would have been lost, and his daughter with him, no doubt.

他心里想，他早上如果没有把那五法郎送给容德雷特姑娘，他早已去跟踪白先生的那辆马车了，因而什么也不会知道，也就没有什么能制止容德雷特两口子的暗害阴谋，白先生完了，他的女儿也一定跟着他一同完了。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。