牙骨质形成

The hypoplasia or aplasia of root cementum was thought to be the prime etiological factor in the early loss of primary teeth.

认为牙根牙骨质形成不全或发育不良是该病患儿乳牙过早脱落的根本原因。

Apoptosis of HERS cells may be the signal of cementum development, and some HERS cells may be directly participate in the progress.

HERS细胞的凋亡可能会为成牙骨质细胞分化提供信号，部分HERS细胞可能参与牙骨质的形成。

Cementum is an important mineralized tissue in root formation, however , the precise mechanism of cementum formation remains undetermined.

牙骨质是牙根形成的重要矿化组织，然而，对牙骨质形成机制仍不十分明确。

All these lines have been proven for their capability of differentiation into odontoblast, dentin, pulp, or cementum in vivo.

这些不同来源的牙齿干细胞，在囓齿动物移植实验中，可以分化为牙本质母细胞，进而形成牙本质，或分化成为牙髓结构，或形成牙骨质。

In practice, this is because just before the out of teeth, root is not fully formed, the pulp cavity and apical foramen are large, thin apical cementum caused.

实际上，这是因为之前出牙，根尚未完全形成，牙髓腔和根尖孔大，薄根尖牙骨质造成的。

The pathogenesis of root resorption is still not clear. Cementoblast plays a central role in repair root resorption by synthesizing cementum matrix.

成牙骨质细胞是牙骨质的功能细胞，在牙根形成、牙周病牙骨质的再生以及正畸相关炎性牙根吸收的修复中起着重要的作用。

During the development of dental germ, enamel matrix proteins secreted by epithelial root sheath could induce dental follicle cells to differentiate towards cementoblast and form acellular cementum finally on the surface of tooth root. Many researches of domestic and oversea scholars suggest that enamel matrix proteins could effectively induce periodontal regeneration, and the structure and function of this regenerated tissue are similar to healthy periodontal tissue. Moreover, the regeneration process is nearly the same to that of embryonic development of periodontal tissue.

自发现釉基质蛋白可诱使牙囊细胞向成牙骨质细胞方向分化并在根表面形成无细胞性牙骨质以来，国内外学者做了大量研究，结果表明釉基质蛋白能有效诱导牙周组织的再生，且这种再生组织的结构和功能更接近于健康的牙周组织，并且再生过程也与牙周组织的胚胎发育过程类似。

The immunohistochemical location of noncollagenous protein, bone sialoprotein , osteopontin and osteocalcin at different stages following periradicular surgery was undertaken. The crystals formation on surfaces of MTA was evaluated when treated in different conditions without cells in vitro and in vivo. MTA was used to manage clinical problems, including perforations in roots or furcations, and pulpless permanent teeth with incomplete root formation. The study included the following three parts

本研究试图通过体内外研究探讨MTA表面牙骨质形成的机理，动物体内动态观察根尖周组织在用MTA倒充填后的组织反应和细胞外基质非胶原蛋白的表达，体外观察MTA在不同的环境下表面的形态及成分变化，和在体内环境下材料表面磷灰石层的形成，同时结合临床病例观察其临床治疗效果。

After transplanted in nude mouse for 8 weeks, DAC-MSCs can regenerate cementum-like structures and dentin-like structures. At the same time, we used limiting dilution assay to screen monoclonal cells from DAC-MSCs and discovered two kinds of phenotype cells: one is osteogenesis type, and the other is fibro singtype.

结果显示：牙根发育期根尖复合体来源间充质干细胞为异质性；具有显著的&胚胎性&组织特征：表现出极高的增殖活性、克隆形成能力和体外多向分化能力；在体内可以异位形成类牙骨质和类牙本质样矿化结构。

AIM: To analyze the apoptosis and proliferation of HERS (Hertwig's epithelial root sheath) and to evaluate the roles of HERS cells in the development of cementum.

目的：观察牙根发育中上皮根鞘细胞(Hertwig's epithelial root sheath， HERS)断裂后结局和增殖凋亡相关基因的表达，探讨上皮根鞘在牙根发育特别是牙骨质形成中的可能作用。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失