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Aim: To observe the changes of the expression of NSE, COX-2 in cerebral tissue in rats withgas toxicosis of acute Anchovy degeneration, and to discuss its molecular mechanism.

目的:观察鱼腐败气体中毒后大鼠脑组织神经元特异性烯醇化酶、环氧合酶(COX-2)表达的变化,探讨中毒的分子机制。

Results: The numbers of Bombesin positive pulmonary cells, the lamina propria S-l00 protein, neuron-specific enolase positive nerve fibers, IgE positive cells, mast cells and IgE positive mast cells significantly increased in bronchiectasis. The changes of pulmonary endocrine cells, nerve fibers and IgE positive cells were more significantly in hyperplastic BALT areas. The S-100 and NSE were found in lymphoid tissue and BALT. A close contact was found between mast cells and the S-100 positive nerve fibers. An IgE positive outer zone was found on MC surface. Mast cells and IgE positive cells were seen in the bronchial epithelium and alveolar septa.

结果:支气管扩张症中,支气管上皮蛙皮素阳性细胞、固有膜S-100蛋白和神经特异性烯醇化酶阳性神经纤维、IgE阳性细胞、MC和IgE阳性MC均显著增多,且在支气管相关淋巴组织增生的区域上述肺内分泌细胞、神经纤维和IgE阳性细胞增多尤为显著,S-100蛋白和NSE阳性神经纤维分布於弥散淋巴组织和BALT中,MC与S-100蛋白阳性神经纤维紧密接触,MC表面有IgE阳性环状带,MC和IgE阳性细胞出现在支气管上皮间和肺泡壁。

Objective To explore the clinical significance of neuron specific enolase level and adenosine deaminase activity change in the cerebrospinal fluid of the patients with intracranial infection.

目的 探讨颇内感染性疾病患者脊液神经元特异性烯醇化酶水平和腺苷脱氨酶活性的变化及其临床意义。

Neuron specific enol enzymeis key enzyme of glycolytic pathway,which exist in neurocyte and neuroendocrine.

神经元特异性烯醇化酶(neuron specific enolase,NSE)是糖酵解途径中的关键酶,它存在于神经组织和神经内分泌系统。

A novel carbonyl transposition led by anilines'nucleophilic addition to methyl 2-keto α-D-glucopyranoside was discovered. And the mechanism of the reaction concerned to an enol rearrangment was provided through tracing the change of 〓H-NMR and 〓C-NMR of a hemiacetal intermediate which was obtained in the reaction of o-phenylene diamine with 2-keto glycoside. Both the intermediate and the converting product were identified by 〓H-NMR,〓C-NMR,〓H-〓H COSY and HMQC.

一、发现了2-位氧化α-甲基D-葡萄糖苷的芳胺亲核加成引起羰基转位的新方法,利用核磁共振氢谱及碳谱对邻苯二胺与2-位氧化α-甲基D-葡萄糖苷加成生成的稳定中间体半缩酮化合物在氘代丙酮中的变化进行跟踪,结合对转化产物的氢氢相关谱和HMQC结构确证,提出了该反应中2-位羰基通过烯醇化互变而转至3-位的机理并得到了验证。

RESULTS: hMSC had good homogeneousness and immunological reaction after implantation.

结果: 第5代呈集落生长的hMSC,均一性好。hMSC可在脑内存活6周以上;随着时间的延长,hMSC在脑内迁移的范围越来越大;间接免疫荧光表明hMSC在大鼠脑内表达人神经元特异性烯醇化酶、神经丝蛋白和胶质纤维酸性蛋白;模型鼠的肢体运动功能有明显改善。

Objective To investigate the changes of neuron-specific enolase in patients with intracerebral hemorrhage.

目的 探讨脑出血患者血浆神经元特异性烯醇化酶的含量变化及意义。

This increase in phagocytosis was inhibited by addition of mannan (50μg) plus mannose (50mM) to the assay medium, suggesting that it was mediated by mannose receptors.

但如果在培养基中加入甘露聚糖(50μg)及甘露糖(50mM),白念珠菌烯醇化酶处理组巨噬细胞的吞噬活力无明显增加。

Objective To explore the diagnostic value of neuron specific enolase detection in lung cancer.

目的探讨血清神经元特异性烯醇化酶检测在肺癌诊断中的价值。

60 grown-up male SD big mice divide into the blank control group, the model group, the Nimmo horizontal group, XXX oral large, medium and small monitoring team stochastically.

目的:探讨XXX口服液对急性脑出血大鼠的神经病态评分、血脑屏障指数及脑组织中神经元特异性烯醇化酶、肿瘤坏死因子表达的影响。

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