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Objective To study the effects of diallyl trisulfide on proliferation, apoptosis and cell cycle in acute myeloid leukemia cells HL-60 and the probable mechanism involved, aiming at offering credible academic and experimental bases for clinical use.

目的:研究二烯丙基三硫对急性髓细胞系白血病细胞株HL-60细胞增殖、凋亡及细胞周期的影响并探讨其作用机制,为二烯丙基三硫用于临床防治癌症提供可靠的理论基础和实验依据。

Part 1 Effects of DATS on proliferation of human bladder carcinoma T24 cells Objective To investigate the effects of diallyl trisulfideon growth inhibition, cell cycle and corresponding molecular mechanism of T24 cells.

中文摘要:第一部分二烯丙基三硫化物对人膀胱癌T24细胞增殖的影响目的研究大蒜提取物二烯丙基三硫化物于体外对人膀胱癌细胞系T24细胞增殖和细胞周期的影响及其可能机制。

Diallyl trisulfide coated stent could significantly enhance the iNOS expression and NO production, which may play an important role in inhibiting neointimal hyperplasia.

烯丙基三硫化物涂层支架可显著增加iNOS表达,并提升NO产量,提示二烯丙基三硫化物涂层支架可能是抑制内膜增生的一个重要机制。

Diallyl trisulfide coated stent could significantly enhance the iNOS expression and NO production, may play an important role in inhibiting neointimal hyperplasia.

烯丙基三硫化物涂层支架可显著增加iNOS表达,并提升NO产量,提示二烯丙基三硫化物涂层支架可能是抑制内膜增生的一个重要机制。

In chapter four, the preperation of ytterbium diiodide was examined. The reductive cleavage of Se-Se bond and S-S bond induced by ytterbium diiodide was investigated. The reaction of diselenides and disulfides with allylic bromide promoted by ytterbium diiodide was also examined. The intermolecular Barbier-type reaction induced by ytterbium diiodide was studied. In the last section of this chapter, the intermolecular reductive coupling of nitriles with azides induced by samarium diiodide was investigated.

第四章,研究了二碘化镱的制备方法,以及二碘化镱作为一种优良的单电子转移试剂在有机合成中的应用:二硒醚的Se--Se键和二硫醚S-S键的还原断裂,及其在合成烯丙基硒醚,硒代酯和烯丙基硫醚,硫代酯中的应用,实验结果表明二碘化镱也能促进分子间的Barbier反应,而文献认为二碘化镱不能促进分子间的Barbier反应;最后研究了二碘化钐促进的叠氮化合物与腈的交叉还原偶联反应,一步高收率地制备脒的方法。

Brominated butyl rubber was prepared by solution method,and its microstructures were characterized by 1H-NMR. It has three main microstructures,that is the unbrominated isoprene structure,the exomethylene allylic bromide structure (structure Ⅱ) and the bromomethyl olefinic structure (structure Ⅲ).

通过溶液法制备溴化丁基橡胶,并用核磁共振对溴化丁基橡胶的微观结构进行了分析,其中存在3种主要微观结构,即未溴化的丁基橡胶结构,溴代仲位烯丙基结构及溴代伯位烯丙基结构。

With industrial monomer solution of dimethyldiallylammonium chloride as raw material, ammonium persulphate as initiator and Na_4EDTA as chelating agent,using the methods of adding initiator all at once,graduated increasing of temperature and stepwise initiation and polymerization,the polymerization process of preparing poly-dimethyldiallylammonium chloride was researched.

以一步法工业单体二甲基二烯丙基氯化铵为原料,以过硫酸铵为引发剂,采用一次性加入引发剂,梯度升温,分步引发水溶液聚合反应的方法,对制备聚二甲基二烯丙基氯化铵的聚合反应的工艺进行了优化研究。

The synthesis of hyperbranched poly based upon 1,2-bis diallyl (methyl silyl ethane (B4) as a core molecule and diallyl silane (AB2) monomer via hydrosilylation addition have been investigated: And the hyperbranched poly were prepared using onestep without core, one-step with core and pseudo-one-step methods.

以四烯丙基硅烷(B4)为核、甲基氢二烯丙基硅烷(AB2)为单体,通过硅氢加成反应,采用无核一步法、核一步法、核多步法合成了超支化聚有机硅破烷。

The results show that the brominated reaction is complete in 1.5 initial contact minutes,an...

结果表明,丁基橡胶的溴化过程只在最初的1.5min内,随着反应时间的延长及在碱性条件下反应,发生了分子结构的重排,即由溴代仲位烯丙基结构向更稳定溴代伯位烯丙基结构转移。

Flame retardant ; bis-sulfone ; bis-sulfone ; etherizing ; phase transfer catalysis ; allyl chloride

阻燃剂;四溴双酚S双烯丙基醚;四溴双酚S ;醚化;相转移催化;烯丙基

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