烯丙基

Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.

我们以水杨酰胺为起始原料，经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2；再从L-羟基脯氨酸出发，经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3；最后由化合物3经脱保护、水解得硫醇，和化合物2在二异丙基乙基胺的作用下缩合，最后Pd／C催化脱保护，历经16步反应最终得到产物多尼培南。

A steel bar is washed and dried, and then put into a glass pipe which is sealed to obtain stirring magneton; a mixed solvent of Gamma-methacrylate oxide propyl trimethoxy silane and methanol is prepared and added with an organic base to obtain a pre-bonding solvent; the stirring magneton is immerged into the pre-bounding solvent, and the outer surface of the glass pipe of the stirring magneton is bonded with a layer of silane substance with alkenyl; a reactive monomer mixture and a pore-forming agent mixed solvent are evenly mixed and then added into a container, the stirring magneton after the pre-bounding is put into the container which is sealed and then put into a water bath; after reaction, the container is removed, the stirring magneton coated with a polymer is taken out and put into a extractor and extracted by using a solvent; or the stir bar is immersed into the solvent till no impurity can be checked in the solvent, thereby obtaining the product.

将铁条清洗干燥，放入玻璃管内，密封得搅拌磁子；配制γ-甲基丙烯酸氧丙基三甲氧基硅烷与甲醇的混合溶液，加入有机碱得预键合溶液，将搅拌磁子浸入预键合溶液，在搅拌磁子的玻璃管外壁键合一层带烯基的硅烷化物质；将反应单体混合剂和致孔剂混合溶液混匀后倒入容器中，将预键合后的搅拌磁子放入容器，密封后置于水浴中，反应后除去容器，取出涂有聚合物的搅拌磁子，置于提取器中，以溶剂提取，或将搅拌棒置于溶剂中浸泡至溶剂中无杂质检出，得产物。

Using N, N-dimethyl-ethylenediamine as cationic substitute and 2-hydroxyethyl methacrylate or allylamine as co-substitute, a kind of pH-sensitive polyorganophosphazenes bearing unsaturated side group was prepared.

以N，N-二甲基乙二胺为阳离子型取代基，甲基丙烯酸羟乙酯或烯丙胺为共取代基，制备了同时带有pH响应性侧基和不饱和双键侧基的聚膦腈。

In addition to cyclopropanation, the typical Diels-Alder reaction between cyclopentadiene and N-acryloyl-l,3-oxazolidinine-2-one with Ll-L8/metal complexes have also been studied.

对于新配体在Diels-Alder反应中的对映选择性的研究，我们采用环戊二烯与3-丙烯酰基-2-噁唑啉酮的反应。

HMT general synthesis is aluminum chloride as a catalyst, isopropyl - toluene right with the new hexene, or 2 January 2 3 1 2 1-butene six-olefins reaction.

HMT的合成一般是以三氯化铝为催化剂，由对异丙基甲苯与新己烯、或2，3一二甲基一2一丁烯等六碳烯烃反应生成。

N-propyl-4-(N-methylacryloxy-ethyl)amino-1,8-naphthalimide was synthesized and used for determination of picric acid.

合成了N-丙基-4-(N-甲基丙烯酰基氧乙基)氨基-1，8-萘酰亚胺，研制出了苦味酸荧光光纤传感器，可间接测定药片中磷酸氯喹和水样中苦味酸的含量。

Promoted by metal dysprosium, aldehydes and ketones could react smoothly with propargyl bromide to afford the corresponding homopropargylic alcohols in good to excellent yields, and no allenic alcohol s were found.

当用苯基炔丙基溴代替炔丙基溴与醛、酮反应时，主要得到了相应的连二烯醇，而没有发现高快丙醇的存在，由此提出了六元环过渡态的反应机理

Poly silica hybrids were prepared through polymerization, condensation and sol gel processes of the mixture of methyl methacrylate, poly and a small amount of coupling agent methacryloxylpropyl trimethoxy siliane in tetrahydrofuran.

采用溶胶-凝胶技术，以硅酸钠为原料制备聚硅酸/四氢呋喃溶胶，再与甲基丙烯酸甲酯及少许偶联剂甲基丙烯酰氧丙基三甲氧基硅烷(MPTMS 混合，经聚合、缩合和溶胶-凝胶过程制备了有机/无机两相间有— C—Si—O—键的杂化材料——聚甲基丙烯酸甲酯/二氧化硅(PMMA/Si O2 )。

Using tetrabutyl titanate and methyl methacrylateor 2-Hydroxyethylmethacrylate (HEMA as materials, methacryloxylpropyl trimethoxy siliane as coupling agent, HCl as catalyst, Poly-titania（PMMA－TiO2） nanocomposites and Poly-titania（PMMA－TiO2） nanocomposites were synthesized by sol-gel process.

以盐酸作为催化剂，将钛酸四丁酯水解制备二氧化钛（TiO2）溶胶；随后将所制备溶胶与甲基丙烯酸甲酯、硅烷偶联剂（γ－甲基丙烯酰氧丙基三甲氧基硅烷）相混合，以过氧化苯甲酰作为引发剂，经过聚合、缩合和溶胶-凝胶过程，制备了均匀透明的PMMA-TiO2纳米复合材料和PHEMA－TiO2纳米复合材料。

We studied the infection ofthe different reactant ratios to the degree of nitration when the polystyrere was nitrified. Thena series PS-NH_2 With different concentrations of amidocyanogen were gained by reducingPS-NO_2. At last the high active acryloylthiourea were grafted on the amidocyamogens.

在聚苯乙烯的硝化过程中，研究了不同的反应物配比对硝化度的影响，并对不同硝化度的硝基聚苯乙烯进行还原反应，得到了胺基含量不同的系列胺基聚苯乙烯，最后利用聚苯乙烯上的胺基和高活性的丙烯酰基异硫氰酸酯进行加成，合成AGPS。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。