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The ear edema of the normal and adrenalectomized mice induced by croton oil, vascular permeability formed by histamine in mice and hind paw edema caused by Carrageenin in rats were used to determine the inhibition to acute inflammnation.

提取物对急性炎症的抑制作用采用巴豆油引起的正常小鼠和摘除肾上腺小鼠的耳肿胀、组胺引起的小鼠毛细管通透性以及角叉菜胶引起的大鼠足肿胀进行分析。

Results The extract remarkably inhibited the contraction caused by histamine and acetylcholine, as well as the ovalbumin sensitized allergic constriction of isolated ileum smooth muscle of guinea pigs. It could inhibit the increase of capillary permeability induced by acetic acid in mice, inhibit the mice paw edema produced by carrageenin and reduce the production of PGE 2 in inflammatory tissues.

结果:辛夷二氯甲烷提取物对组胺、乙酰胆碱(Ach引起的豚鼠离体回肠收缩具有显著的抑制作用,并能抑制卵白蛋白所致的豚鼠离体回肠过敏性收缩,对HAc引起的小鼠腹腔毛细血管通透性增高具有抑制作用,能显著抑制角叉菜胶引起的小鼠足肿胀,并减少前列腺素E2(PGE2)在炎症组织中产生。

The experimental results showed that the extract of aerial parts of TWHf can markedly inhibit the aurcular swelling induced by croton seed oil and the capillary permeability in mice,reduced the primary pathologic changes induced by Freund's complete adjuvant,and exerted preventive and therapeutic effect on the secondary pathologic changes.

结果表明:雷公藤地上部分浸膏对巴豆油诱发的小鼠耳廓炎症、小鼠毛细血管通透性有明显的抑制作用;对弗氏完全佐剂所诱发的大鼠原发性病变有明显的拮抗作用;对继发性病变也有明显的预防和治疗作用。

PART FOUR EFFECTS OF MIL-4RA EXPRESSION VECTOR ON ASTHMATIC AIRWAY INFLAMMATION AND TH1/TH2 CELL DISFUNCTION THROUGH INTRAPERITONEAL ADMINISTRATION In the study of part three, we treated the mouse asthmatic model by intratracheal administration with mIL-4RA expression plasmid and observed obvious therapeutic effects. But intratracheal administration belongs to one of the insult therapies.

第四部分:腹腔注射mIL-4RA重组载体对哮喘小鼠气道炎症及Th失衡的干预作用前一部分研究中我们通过气道局部干预途径,即气管内直接滴注的方式,观察到mIL-4RA真核表达质粒对哮喘小鼠具有很好的治疗作用,但气管内滴注毕竟属有创性治疗,存在需要实验条件高,有较大的风险性,不易反复进行等缺点,这势必大大限制其在动物实验及进一步临床研究中的实际应用价值。

The term myalgic encephalomyelitis is still commonly used; Myalgia is muscle pain, and encephalomyelitis refers to inflammation and dysfunction of the brain and spinal cord. Whilst this may be accurate in some cases, ME is now considered to be too specific to cover the range of symptoms experienced.

任期myalgic性脑脊髓炎的仍是常用的; myalgia 是肌肉疼痛,和 encephalomyelitis 是指炎症和功能障碍的脑和脊髓,虽然这可能是准确,在某些情况下,我现在被视为过于具体,涵盖的范围,症状有经验的。

Diabetic retinopathy is one of the most serious microvessel complications of diabetes,it is a main cosmopolitan blindness disease. In recent years, with the molecular biology development, the recognition of the mechanism of DR is more profound and consummate. Most researchers consider that hyperglycaemia, polyalcohol inositol metabolism abnormality, changes of hemorrheology, oxidative stress, inflammation/immune system activation, cytokines/growth factors expression or activity change and so on result in DRs onest and development.

糖尿病性视网膜病变(diabetic retinopathy, DR)是糖尿病最严重的微血管并发症之一,也是一种世界性的主要致盲眼病,近年来随着分子生物学方面的研究进展,对DR发病机制的认识进一步深入和完善,认为高血糖、多元醇肌醇代谢异常、血液流变学改变、氧化应激、炎症/免疫系统活化、细胞因子/生长因子表达或活性改变等导致DR的发生发展。

Wound healing of rat skin may be arbitrarilydivided into the following stages: wound generation, suppurating in someinflammation area, growing of granulation tissue, scab formation,decrustation, and completely healing. The wound depth and the extent ofhealing also could be determined from the OCT images in the different healingtime. Healing time for the skin scald was found to be much shorter than those ofthe skin wound. Because the skin wound is serious than the skin scalds. 3 The result of using OCT to monitor the model of acetic acid gastric ulcer in rats:Results of this experiment showed that using OCT technology can identify theulcerative gastric mucosa tissues with normal tissues, make the imaging on theunder-layer of gastric mucosa tissues, and evaluate the healing period and healingquality. From the OCT images can be clearly found the acetic acid gastric ulcer.

3大鼠胃溃疡模型的OCT成像检测结果:实验结果显示利用OCT能够实现溃疡组织的成像,可显示正常胃壁组织的层次性结构,对于溃疡病变过程中可对黏膜下病变的深度与状况进行成像分析,从图像可以很明显的发现溃疡性炎症病变区域(这个区域由于散射光变弱,颜色相对比较暗),在愈合的后期黏膜层基本愈合的状态下仍可显示黏膜下层组织的增生、未能完全愈合等病理改变。

TGFβ is a kind of homotype dimer polypeptide. It shows a high affinity with serine/threonine recipient albumen. It also has an extensive biological effect and features the function of restraining the proliferation of several kinds of cells and helping the inflammationand wound healing.

TGFβ是一种同型二聚体多肽,与跨膜丝氨酸/苏氨酸受体蛋白具有较高的亲和性,具有较广泛的生物学效应,较显著的是抑制多种类型细胞的增殖以及在炎症愈合和创伤愈合中的作用。

The aim of our study was to analyse the interdependence of inflammation, neurodegeneration and disease progression in various multiple sclerosis stages in relation to lesional activity and clinical course, with a particular focus on progressive multiple sclerosis.

我们的研究目的是,在与病灶活动性及临床病程相关的多发性硬化症的不同阶段,分析炎症、神经退行性病变和疾病发展间相互依赖的关系,尤其侧重于对多发性硬化症进展期的研究。

Our result suggested that ZHG-II can improve sufferers living quality and clinical symptom by meliorating their intensity stress, and delay the inflammatory and proliferous process of psoriasis by adjusting the level of NP.

提示竹黄颗粒剂Ⅱ号通过改善紧张性应激,提高了患者的生活质量及临床症状;通过对神经肽的含量的调节作用,以缓解银屑病的炎症和增殖进程,而达到治疗的目的。

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