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Ping chuan-fang prescription is carefully composed accordingly. The clinical investigation shows that PCHF can not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviously can not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviously improve the pulmonary function of the patient. The animal experiment showed that PCHF can prolong the asthmatic time and low the concentration of WBC, EOS, IL-4, ET-1 in the blood and BALF. It can restrain the collection of EOS in the lung and relieve the inflammation caused by EOS. It also can cut down the secretion of the respiratory air-way and relieve the obstruction of it.

动物实验表明:平喘方能明显延长卵蛋白造模大鼠的引喘潜伏期,且与氨茶碱对照有非常显著性差异(P<0.01);能降低哮喘模型大鼠血浆及肺泡灌洗液中白细胞、嗜酸性粒细胞及IL-4、ET-1的含量;能抑制肺局部EOS的聚集,明显减轻由EOS浸润引起的慢性变应性炎症反应;能减少气道分泌物,减轻细支气管及小血管管壁的增厚,减轻周围组织的水肿,从而减轻气道的阻塞,最终改善肺通气,缓解喘息症状。

Ping chuan-fang prescription is carefully composed accordingly. The clinical investigation shows that PCHF can not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviouslycan not only alleviate symptoms and physical sign of the patients effectively, but also shorten the course of disease and obviously improve the pulmonary function of the patient. The animal experiment showed that PCHF can prolong the asthmatic time and low the concentration of WBC, EOS, IL-4, ET-1 in the blood and BALF. It can restrain the collection of EOS in the lung and relieve the inflammation caused by EOS. It also can cut down the secretion of the respiratory air-way and relieve the obstruction of it.

动物实验表明:平喘方能明显延长卵蛋白造模大鼠的引喘潜伏期,且与氨茶碱对照有非常显著性差异(P<0.01);能降低哮喘模型大鼠血浆及肺泡灌洗液中白细胞、嗜酸性粒细胞及IL-4、ET-1的含量;能抑制肺局部EOS的聚集,明显减轻由EOS浸润引起的慢性变应性炎症反应;能减少气道分泌物,减轻细支气管及小血管管壁的增厚,减轻周围组织的水肿,从而减轻气道的阻塞,最终改善肺通气,缓解喘息症状。

Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后,易感神经元会萎缩直至死亡,原因可能有兴奋性中毒(神经递质对神经元表面受体的过度刺激引起),钙稳态失衡,炎症反应,能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合,可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应,也可调节不同信号级联反应,这些级联反应对于维持神经元活动性和生存性意义重大。

Boosts warm water bag of wound healing tepidity being able to stimulate the effect organizing regeneration and having lighten pain and reinforce organization nutrition , large amount of seriflux exudate increases by , can help to eliminate pathological mechanism outcome when the wound thinking that the tepid effect administers medicine to bring out the cold in the body,; Another , fever may distend the blood-vessel , blood vessel Tongtou sex strengthens, snapout beneficial to organizing supersession outcome and the sorption to nutrient substance, restrain development of inflammation , promote a wound healing.

促进伤口愈合暖水袋的温热可以刺激组织再生且有减轻疼痛和加强组织营养的作用,当温热作用于体表的创口时,大量浆液性渗出物增多,能协助清除病理产物;另外,热会使血管扩张,血管通透性增强,有利于组织代谢产物的排出和对营养物质的吸收,抑制炎症的发展,促进伤口愈合。

Role of endothelial function and inflammation in patients with cardiovascular risk factors, with and without a history of myocardial infarction;Comparison of gated blood pool SPECT and multidetector row computed tomography for measurements of left ventricular volumes and ejection fraction in patients with atypical chest pain: Validation with radionuclide ventriculography;Plasma adiponectin, T94G gene polymorphism and PAI-1 in patients with and without hypertension;Prognostic value of myocardial perfusion imaging in symptomatic and asymptomatic patients after percutaneous coronary intervention;Impact of early initiation of intravenous therapy for acute decompeusated heart failure on outcomes in ADHERE……

文章摘要:内皮功能和炎症在有或无心肌梗死病史的具有心血管危险因素患者中的作用;门控血池SPECT和多层螺旋CT对于测量不典型胸痛患者左室容积和射血分数的比较:以放射性核素心室造影检查进行验证;有或无高血压的患者的血浆脂联素、T94G基因多态性和PAI-1;心肌灌注成像对经皮冠状动脉介入后有症状和无症状患者的预后评估价值;ADHERE中早期开始静脉用药治疗急性失代偿性心力衰竭对预后的影响

The reason is that warm has functions of stimulating tissue regeneration, alleviating pain and increasing tissue nutrition, when warm acts on surface wound, serous effusion increases, which helps to eliminate pathological products; warm can make blood vessel dilative and enhance vascular permeability, which is propitious to discharge tissue metabolites, absorb nutriment, restrain development of inflammation and advance the healing.

究其原因,是因为温热可刺激组织再生且有减轻疼痛和加强组织营养的作用,当温热作用于体表的创口时,浆液性渗出物增多,能协助消除病理产物;热可使血管扩张,血管通透性增强,有利于组织代谢产物的排出和对营养物质的吸收,抑制炎症的发展,促进其愈合。

Their behaviour,activity,hair,feces were not found abnormal.Their food-intake and body weight were without any obvious variation;(2) After the experiment periods of three months and six months,the hematology examination of rabbits in all Ogroups and in all B groups was not made with distinct difference;(3) The blood biochemical measurement values in Ogroups and in B groups were basically similar;(4) When the systematic thanatopsia of laboratory rabbits,one rabbit each in a high-dose O group and a B group demonstrated 2-3 yellow-white circular nodes as large as a green bean in lingula pulmonis sinistri.Ohter organs were not found of obvious pathologic changes;(5)With the histopathology examination,the pathologic change of lung tissue seem by naked eyes was a focal suppurative inflammation under microscope.

其行为、活动、被毛、粪便等未见异常,进食量及体重变化未见明显差异;(2)实验期3个月、6个月的血清学检查,各药膏组与空白药膏组比较无显著差异;(3)药膏组与空白药膏组的血液生化测定值基本一致;(4)各药膏组实验兔的系统尸检表明,用药期空白药膏组和高剂量药膏组各有一只实验兔的肺心叶有2~3个黄白色绿豆大小圆形结节,其他脏器未见明显病变;(5)病理组织学检查,肉眼见到的肺组织病变镜检为局灶性化脓性炎症,其他组织未见病理性改变。

The individuals carrying the IL1RN*2 allele have a lower circulating level of IL-1ra in response to inflammation thereby inducing an increased activity of IL-1 which could be responsible for trigging the development of clinical manifestation in IgA nephropathy and Henoch-Schonlein nephritis.

为了进一步揭示IL-1ra基因多态性与其表型之间联系的本质,在本研究中我们对IL-1ra不同基因型IgAN和HSPN患者外周血单核细胞在炎症因子刺激下IL-1ra的产生能力进行了研究,以期阐明IL-1ra基因多态性对其功能的影响。

Our understanding of the pathogenesis of CP has improved in recent years, though important advances that have been made with respect to delineating the mechanisms responsible for the development of pancreatic fibrosis following repeated acute attacks of pancreatic necroinflammation (the necrosis-fibrosis concept).

虽然慢性胰腺炎重要的进展在于阐述反复急性胰腺坏死性炎症后胰囊性纤维化的发生机制方面,但最近几年我们对于慢性胰腺炎发病机理的理解已有所更新。

Our understanding of the pathogenesis of CP has improed in recent years, though important adances that hae been made with respect to delineating the mechanisms responsible for the deelopment of pancreatic fibrosis following repeated acute attacks of pancreatic necroinflammation (the necrosis-fibrosis concept).

虽然慢性胰腺炎重要的进展在于阐述反复急性胰腺坏死性炎症后胰囊性纤维化的发生机制方面,但最近几年我们对于慢性胰腺炎发病机理的理解已有所更新。

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