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炎症

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Objective: To study the expression level of MCP-1 mRNA after spinal cord injury and its role in the secondary immunoreaction at the early stage after SCI.

目的:探讨炎症细胞趋化因子单核细胞趋化蛋白1(MCP-1)在脊髓损伤早期的表达变化及其在脊髓继发性损伤炎症免疫反应中的作用机制。

It is generally accepted that mediators play an important role in inflammation.

炎症介质在炎症反应中具有十分重要的地位。

The present study analysis whether CRP could directly induce inflammation in endothelial cells, analysis what kind of effects CRP provide on cellular signal transduction in endothelial cell by gene array, and isolate LDL by one step of density gradient centrifugation, generate E-LDL by degrading LDL with multiple enzymes, direct fluorescent labeling CRP and LDL, investigate whether CRP play as intermediator in atherosclerosis.

本课题目的在于探讨CRP在脂质参与的动脉粥样硬化形成中是否起到介质作用,主要通过检测直接CRP能否诱导内皮细胞炎症表现,基因芯片分析CRP对内皮系统的细胞信号转导通路的影响,探讨CRP参与调控内皮系统炎症过程的主要机制,并且通过一步法密度梯度离心分离LDL,复合酶处理生成E-LDL,直接荧光标记CRP和LDL,分析CRP介导脂质紊乱尤其是LDL代谢产物参与动脉粥样硬化早期形成的作用。

Objective To study the effects of statins on CRP and IL-6,and to evaluate the influence of statins on nflammation of vessel.Methods Observing CRP and IL-6concentration varieties on patients with coroˉnary artery disease before and after giving statins,evaluating the varieties of CRP and IL-6on the patients with high lipemia and normal lipemia,and assessing the effects of statins.

目的 研究他汀类药物对IL-6和CRP两炎症因子的作用,从而了解它对血管炎症的影响方法评估冠状动脉疾病的患者用他汀类药物后CRP和IL-6的变化,并分别评估高血脂和血脂正常患者IL-6和CRP的变化,以及他汀类药物对两组患者的作用。

The experimental result shows:1 acupuncture and moxibustion on DU4 and RN4 can lighten inflammationreact , suppress the inflammation course, DU4 has the best result.2 IL-2 is the important factor of participating the immune respondence.Acupuncture and moxibustion can increase IL-2 content in the blood , thusstrengthen the immune function of the organism .3 acupuncture end moxibustion can raise β-EP content of lower thalamus ,hypophysis , lymph gland. it proves that acupuncture and moxibustion can stimulateand accelerate compound、store 、process 、shifting utility of β-EP content; andstrengthen the immune regulating function of the organism, acupuncture function isstrong rapidly, moxibustion function is slow and gentle, the regulating action powerof moxibustion has close relations with choice of the point . The possible reason isthat y whether acupuncture and moxibustion bring into play their regulating actionthrough different way of neural body fluid.4 The DU4、RN4、FEI point influence rule apply on change of β-EP content ofabove-mentioned organism.

实验结果显示:1 针灸命门和关元穴能减轻炎症反应,抑制炎症过程,命门穴效果最好。2IL-2 是参与免疫应答的重要因子,而针灸能增加血中 IL-2 含量,从而增强机体的免疫功能。3 针刺和艾灸可以升高下丘脑、垂体、淋巴结β-内啡肽含量,说明针灸可以刺激并加速β-内啡肽含量合成、储存加工和转移利用;增强机体的免疫调节功能,针刺作用迅速强烈,艾灸作用缓慢温和,艾灸的调节作用强弱还与穴位的选择有密切关系。

Results Both dosages of 153 Sm have an initial pro-i nflammatory effects during one week after injection,and then resulted in reducti on of joint diameter and skin surface temperature.153Sm (3.7×107 Bq) s howed a more alleviation than 153 Sm (1.85×107 Bq) in respect of macr oscopic and histologic changes.

注射153Sm(1.85×107Bq)导致一过性炎症反应,7 d后肿胀和局部发热缓解,并持续36 d.153Sm(3.7×107Bq)同样有一过性炎症反应,7 d后缓解,关节直径和皮肤温度较对侧关节有差异(P<0.05),并一直持续至处死前未改变。而大体形态学和病理学可见滑膜炎减轻,其指标与对侧相比差异有显著性(P<0.05)。

The association between cardiac disease and lower dietary macronutrient and micronutrient intake in CAPD patients was mediated in part through systemic inflammation, which also was associated with more malnutrition.

持续性不卧床腹膜透析的心脏病患者低饮食营养成分和微量元素部分是由于系统性炎症导致的,系统性炎症也与营养不良相关。

Brain inflammation and inflammation of the meninges occasionally occurs.

炎症炎症的脑膜,偶尔发生。

achieves function of injury patient immunity badly to be restrained, the percentage of monocyte surface HLA-DR and inflammation factor CRP, WBC has factor of dependency; inflammation and immune function may be an influence mussily evolutional of patient's condition of the much patient that send an injury is important element.

结论严重创伤患者免疫功能受到抑制,单核细胞表面HLA-DR的百分率和炎症因子CRP、WBC有相关性;炎症因子及免疫功能紊乱可能是影响多发伤患者病情进展的重要因素。

According to 97 UICC classification, T_1 was 14 cases, T_214, T3 14 and T_4 11; N_0 was 15 cases, N_1 22, N_2 11 and N_3 5; Stage I was 5 cases, II 13, III 20 and IV 15. 10 nasopharyngeal biopsy specimens were collected from patients with chronic nasopharyngitis who had been diagnosed definitely by HE stain in the same hospital (male 6 and female 4), which were served as normal controls.

分期根据97UICC标准:T_1 14例,T_2 14例,T_3 14例,T_4 11例;N_0 15例,N_1 22例,N_2 11例,N_3 5例;Ⅰ期5例,Ⅱ期13例,Ⅲ期20例,Ⅳ期15例。10例鼻咽部慢性炎症常规石蜡切片标本也由浙江省温岭市第一人民医院病理科提供,HE染色确诊为鼻咽部慢性炎症,其中男性6例,女性4例,作为对照组。

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