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炎症

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Results(1) Group of electroacupuncture in Shu and dense wave can significantlyreduce the degree of ankle swelling(P<0.05, P<0.01), which shows thatelectroacupuncture has obvious anti-inflammatory and repercussive roles;(2) Theresults of HE staining showed that group of electroacupuncture in Shuand dense wave can significantly reduce inflammatory cell infiltration,inhibit synovial cell proliferation, and decrease proliferation of granulationtissue in rats joints;(3) group of electroacupuncture in dense-wave can increase the pain thresholdof experimental rats (P<0.05, P<0.01), reduce the content of peripheral painmediums, such as K~+, DA and 5-HT(P<0.05, P<0.01), which shows thatelectroacupuncture has significant analgesic effect;(4) In the local lesion of joints, electroacupuncture can significantly reducethe content of IL-1β, IL-8, TNF-a, increase IL-4 content, decrease theexpression of COX-2mRNA, and significantly promote the expression ofHSP-70 protein in synovial tissues of acute gouty arthritis rats (P<0.05,P<0.01),thus restrain the occurrence of synovial tissue inflammation.

结果:(1)电针疏密波组能显著减轻踝关节肿胀度(P<0.05,P<0.01),表明电针有明显的抗炎消肿作用;(2)HE染色显示:电针疏密波组可使大鼠关节炎症细胞浸润明显减轻,滑膜细胞增生明显被抑制,肉芽组织增生明显减少;(3)电针密波组能提高实验性大鼠痛阈(P<0.05,P<0.01),降低外周疼痛介质K~+、DA、5-HT的含量(P<0.05,P<0.01),表明电针有明显的镇痛作用;(4)在病变关节局部,电针能显著降低急性痛风性关节炎大鼠滑膜组织IL-1β、IL-8、TNF-α含量(P<0.05,P<0.01),升高IL-4的含量(P<0.05,P<0.01),并降低关节滑膜内COX-2mRNA的表达(P<0.05,P<0.01),可促使急性痛风性关节炎大鼠滑膜内HSP-70蛋白表达显著增加(P<0.05,P<0.01),从而抑止滑膜组织炎症发生。

On a variety of seborrheic dermatitis, inflammation and itching of ringworm and other skin inflammation has specific therapeutic effects.

对各种脂溢性皮炎、癣性炎症和瘙痒等各种皮肤炎症有明确的治疗作用。

The pathogenesis of asthma can be divided into three stages in immunology. The initial stage is sensibilization, which is closely associated with the activation of T cells. B7/CD28 and CD69 also play a significant role in this process. The second stage is chronic allergic inflammation. The immune dysfunction resulting from the disturbance of TH1/TH2 is a major cause of chronic allergic inflammation, and dominates asthma attack. And the third stage is airway remodeling due to chronic inflammation. Airway remodeling is one of the major causes of refractory asthma, which also contributes to the death from asthma.

哮喘的发病从免疫学角度可以分为三期:初期为致敏阶段,与T细胞激活关系密切,B7/CD28和CD69在这一过程也扮演重要角色;第二期为慢性过敏性炎症阶段,TH1/TH2失衡导致免疫功能紊乱是此阶段的主要原因,在哮喘发作过程中起主要作用;第三期为慢性炎症引起的气道结构重构阶段,是难治性支气管哮喘的重要发病和死亡原因。

Objective To reproduce the inflammatory bowel disease models induced by 2,4,6- trinitrobenzene sulfonic acid,and to investigate the effect of Changkangyin on it.

目的:应用2,4,6-三硝基苯磺酸复制炎症性肠病动物模型,观察中药肠康饮对炎症性肠病的干预作用。

In other words, in many people, exercise might be as effective as an Rx in tamping down inflammation, one of the key risk factors for cardiovascular disease.

换句话说,对许多人来说,锻炼也许与抑制炎症的药方一样有效,而炎症是心血管疾病的主要风险因素。

RESULTS: During 10 - 12 weeks, in cuntrol group: The defect area was repaired by white and soft tissue that had no resistance to press. The repaired tissue was still lower than the surrounding articular surface with clear boundary. By histological observation, it was found that the defect was repaired by the mechanism similar to inflammatory reaction and the defect is ultimately filled by the hyperplasia of hyaline degenerative fibrous tissues. In filling group: the defect was repaired by semi-transparent, smooth, textured tissues with polish that had resistance to press as well as elasticity. The repaired tissue was almost similar to the shape of the surrounding cartilage,difficult to be distinguished. After histological observation, it was found that there was no inflammatory reaction, but active hyperplasia of inner bonetissue and cartilage tissues; a lot of osteoid tissues and trabeculation were found. Newlborn cartilage was fused with surrounding cartilage tissue and connected with surrounding tissues.

结果:10~12周,对照组:缺损区由白色、质软、按压无阻抗的组织修复,修复组织仍低于周围关节面,边界仍清晰可辨,组织学以类似炎症反应的机制修复缺损,最终以透明变性的纤维组织的增生来填补缺损部位;填充组:缺损区由半透明状、质韧光滑有光泽,按压有阻抗并有弹性的组织修复,修复组织与周围软骨外形上已基本相似,不易区分,组织学未见有炎症反应的过程,内骨组织和软骨组织增生活跃,并可见大量类骨组织和骨小梁形成,新生软骨和周围软骨组织融合,并与周围组织连接。

Background and Objictive:Crohns disease is a main type of inflammatory bowel disease,and is a segmental transmural inflammatory disease of gastrointestinal tract.

背景、目的克罗恩病是炎症性肠病的一个主要类型,是全胃肠道节段性全层炎症性病变。

She is especially good at the management of the eyeground diseases, such as ocular fundus bleeding from various reasons, retinal vascular diseases (such as diabetic retinopathy, retinal vein occlusion, retinal artery occlusion, retinal vasculitis etc.) from diabetes mellitus, hypertension, or various inflammation, retinal capillary hemangioma, vitreous hemorrhage caused by various retinal diseases, optic neuritis, ischemic optic neuropathy, retinal detachment, macular diseases (such as age related macular degeneration, central serous chorioretinopathy, central exudative chorioretinopathy etc.), and other complex diseases such as uveitic diseases and glaucoma etc.

特别是对眼底病如各种原因所致眼底出血;糖尿病、高血压、各种炎症所引起的视网膜血管病如糖尿病视网膜病变、视网膜静脉阻塞、视网膜动脉阻塞、视网膜血管炎症等;视网膜血管瘤病以及其他各种视网膜病所致玻璃体出血;视神经炎、视神经缺血、视网膜脱离、黄斑部疾病如老年性黄斑变性、中浆、中渗等及其他疑难病如葡萄膜炎,青光眼等的诊治积累了大量的临床经验。

Followed by laboratory tests to exclude such as epididymitis, Seminal Vesiculitis, genitourinary tract inflammation, prostatitis factors such as bacterial infection.

接下来是实验室检查,排除例如附睾炎、精囊炎、泌尿生殖道炎症、前列腺炎症等细菌感染的因素。

Our researches include:To establish the rat experimental model of VILI and study the the activation of the receptor of cellular membrane in VILI;To observe the change of transmembrane signal transduction and inflammation cytokine after applying the specific blocking agent of receptors;To observe the change of transmembrane signal transduction and inflammtion cytoking after applying the no specific blocking agent of receptors.

主要内容建立大鼠VILI实验模型,观察各种细胞膜受体(包括整合素受体、生长因子受体、G蛋白偶联受体)及其配体在大潮气量机械通气时的表达变化;应用各种受体的特异性阻断剂,观察对大鼠VILI信号转导通路以及炎症因子表达的影响;应用各种非特异性阻断剂,观察对大鼠VILI信号转导通路以及炎症因子表达的影响。

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