灶

Abstract］ objective to study the pathological features and histopathological type and differential diagnosis of hepatic focal nodular hyperplasia.methods the clinicopathological characteristics of 40 cases of fnh were studied.all were evaluted by use of paraffin embedded sections and he staining before light microcope observation.results there were 28 females and 12 males fnh patients whose age were from 16 to 62 years（median 41.3）,all alpha-fetoprotein was negative and had no hepatitis history.25 cases were classic type showed characteristic central stellate fibrotic scar,composed of fibrous connestive tissue and tortuous blood vessels.8 cases were telangiectic type,the left were mixed type and adenomatoid type.conclusion fnh is a reactive proliferation of hepatic cells to local blood vessel anomalies,it is not realy a tumor.its differential diagnosis includes hepatic adenomatous hyperplasia nodule,hepatic anaplasia nodular hyperplasia,fibrolamellar hepatocellular carcinoma and hepatocellular adenoma.

目的 探讨肝局灶性结节性增生的病理形态特点、组织分型及鉴别诊断。方法分析40例肝局灶性结节性增生的临床资料，并采用石蜡包埋he染色光镜下观察其组织学特点。结果 40例肝局灶性结节性增生患者中，女28例，男12例，年龄18~62岁，平均年龄41.3岁，所有病例术前均无肝炎病史，甲胎蛋白阴性，组织学上25例为经典型，有特征性的中央纤维瘢痕，由纤维结缔组织及扭曲血管组成。8例为毛细血管扩张型，其余为混合型及腺瘤样增生型。结论肝结节性增生是一种肝细胞对局部血管的异常反应性增生，并非真性肿瘤，主要与肝腺瘤样增生性结节、肝间变性结节状增生、肝纤维板层癌及肝细胞腺瘤鉴别。

HE staining and prussian blue staining in all transplantation mice were done and the result of the staining was analyzed. RESULTS: The macrophages were seen in the inner of 2 subcutaneous ectopia transplantation tumor models and the kupffer cells were found in the inner of 3 subcutaneous ectopia transplantation tumor models by Prussian blue staining.

结果： Prussian blue染色皮下移植瘤组有2只瘤鼠的瘤灶内见较为聚集的单核/巨噬细胞，肝脏移植瘤组中3只瘤鼠的瘤灶内见枯否细胞；肝脏移植瘤组见7个瘤灶与正常肝组织呈明显的浸润性生长。

Results:"Zusanli"(ST 36) acupuncture at acupoint " the gneration of needling sesations " in the experimental group,fMRI-BOLD show belong to the brain limbic system temporal lobe,hippocampus, cingulate gyrus,hypothalamus,insula lobe in the brain there is a corresponding functional areas have different levels of excited stove back at both the central cluster can be seen in small foci excited;in the control group,fMRI-BOLD shows that the brain can be scattered at small punctate foci excited,bilateral post-central point within the sheet can be seen in small foci excited.

结果：在针刺足三里穴"得气"的实验组，fMRI-BOLD显示属于大脑边缘系统的颞叶、海马回、扣带回、下视丘、岛叶中的相应脑功能区有程度不同的兴奋灶，在双侧中央后回可见小簇状兴奋灶；在对照组，fMRI-BOLD显示大脑内可在散在的小点状兴奋灶，双侧中央后回可见小的点片状兴奋灶。

Results Metaphysis osteoporosis was observed on X-ray and CT in acute stage, the midsection of infarct of bone was isointensity on T1WI and iso/hyperintensity signal on T2WI, the edge of infarct of bone was ring-shaped hypointensity on T1WI and hyperintensity signal on T2WI. Small worm-eaten change and stippled calcification was observed on X-ray and CT in subacute stage, the infarct of bone was iso/hypointensity on T1WI and iso/hyperintensity signal on T2WI, the edge of infarct of bone was ring-shaped hypointensity on T1WI and hyperintensity signal on T2WI. Irregular and wriggle osteosclerosis was observed on X-ray and CT in chronic stage, was hypointensity on T1WI and T2WI.

结果 骨梗死急性期X线、CT表现为干骺端骨质疏松，MR T1WI骨梗死灶中央部分呈等至高信号，T2WI呈高信号，T1WI骨梗死灶边缘呈环形低信号，T2WI呈环形高信号；亚急性期X线、CT表现为小的虫噬样改变，伴有斑点状钙化，MR T1WI骨梗死灶呈等或低信号，T2WI呈等或稍高信号，T1WI骨梗死灶边缘呈环形低信号，T2WI呈环形高信号；慢性期X线、CT表现为不规则状、蜿蜒状骨质硬化，MR T1WI和T2WI均呈低信号。

At postoperative 24 hours, neurological defects were scored in five grades [0 score represent no neural impairments; 1 score: the left posterior limbs displayed decreased muscular tension and attenuated contraction reflex; 2 scores: the left posterior limbs were paralyzed, displaying obvious abduction; 3 scores: rabbit displayed obvious adductive drag with body leant to the opposite side; 4 scores: unable to walk and unconsciousness], rabbits were put to death at postoperative 48 hours, infarctional area and volume were determined and pathological changes was also observed.

术后48 h处死兔，测量梗死灶面积、体积，并制作病理切片观察损伤程度。主要观察指标：兔肢体功能状态，脑梗死灶面积和体积，病理损伤程度。结果：59只兔成功建立起梗死灶，模型成功率为98％。①神经功能缺失评分：56只兔为1或2分，有3只兔达到3分。②梗死灶平均面积为(0.465±0.012)cm2，平均体积为(0.268±0.009)cm3。

Results ①The most common lesions were the extragastric compressions caused by spleen, which accounted for 54.74%, followed by the enlarged gallblodder, hepatic cyst and carcinoma in the left lobe, left kidney, pancreatic cystic adenoma and pancreatic cyst.②The diagnostic accurancy of EUS was 100%, which was higher than that of USP.③Most of the lesions, benign or malignant, had normal structure of the gastric wall.④Splenomegaly only accounted for 38.46% in the lesions caused by the compression of spleen, which were slightly to moderately enlarged.⑤The location of the lesion was usually related to the organ which caused the extragastric compression.

结果 ①胃外压性隆起中脾脏压迫最多见，占54.74%，其余为肿大胆囊、肝右叶囊肿、肝左叶癌、左肾、胰腺囊腺瘤和胰腺囊肿；②EUS对胃外压性隆起的诊断正确率达100%，其对外压灶的完全显示率高于微超声探头；③良性胃外压灶及多数恶性肿瘤胃外压灶其所压胃壁结构均正常；④脾脏压胃者中脾肿大仅占38.46%，且均为轻、中度脾肿大；⑤胃隆起部位与外压灶的种类相关联。

Methods The expression of P73 in 92 cases of colorectal carcinoma tissue, 10 cases of colorectal polypous adenoma tissues, 34 cases of lymph node metastasis, 16 cases of liver metastasis, and 10 cases of normal colorectal tissues were measured by PV immunohistochemical approach.

选取92例大肠癌组织标本，腺瘤10例，淋巴结转移灶34例，肝转移灶16例，癌旁正常组织10例，通过免疫组化PV-9000通用型二步法检测P73在上述标本中的表达，分析P73在原发灶，转移灶，癌旁正常组织中的表达情况，与大肠癌临床病理参数的关系。

Expression of β-catenin in metastatic carcinomas was significantly lower than that in primary colon carcinomas (p.01). expression of e-cadherin in metastatic carcinoma was significantly lower than that in primary colon carcinoma(p.01),especially in tubiform adenocarcinoma and well and moderately differentiated carcinoma.

结果］ 原发灶及其淋巴结转移灶中β-结肠术后多久的正常表达率分别为23.46%和4.94%，原发灶中术后多久高于转移灶(p.01)，尤其是高中分化病例，转移灶中异位表达率显著高于原发灶(45.68%比28.40%，p.01)，尤其是管状腺癌；原发灶中β-cat表达强度显著高于转移灶(p.01)。e-cad的表达强度在原发灶显著高于转移灶(p.01)，尤其是管状癌症治疗和高中分化病例。

(1)In NSCLC, the overexpression of Ezrin and the abnormal expression of E-cadherin were correlative with primary carcinoma with metastatic carcinoma. The expressions of Ezrin and E-cadherin in primary NSCLC tissues and in metastatic carcinoma of lymph nodes were different. All of these suggested that the overexpression of Ezrin and the abnormal expression of E-cadherin may promote tumor metastasis. The investigation of Ezrin and E-cadherin may be useful for offering one method to prevent tumor from metastasizing.

(1)在NSCLC中，Ezrin的过度表达与伴有癌转移的原发性NSCLC有关，并且在淋巴结转移灶中的过度表达高于原发灶；E-cadherin的异常表达与伴有癌转移的原发性NSCLC有关，并且在淋巴结转移灶中的异常表达高于原发灶；以上均提示Ezrin过度表达和E-cadherin异常表达可能促进肿瘤转移，对Ezrin与E-cadherin的研究可能有助于提供一种阻止NSCLC患者肿瘤转移的治疗措施。

CR for the axillary lymph nodes and two 50. 0 % PRs each for metastases in the liver and the lung , respectively , were found.

乳腺原发灶OR 7714 %，CR 1611 %；转移灶OR6113 %， CR 615 %，其中腋窝淋巴结转移灶OR 6810 %，CR 810 %；肝、肺转移灶各部分缓解 5010 %。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了