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AIM: To determine the time course and peak production of reactive oxygen species in suprahepatic vena cava after hepatic ischemia-reperfusion and to study the effects of posthepatic manipulative bleeding on HIR injury in rat model.

目的:确定肝脏缺血再灌注时肝上下腔静脉血中氧自由基产生的时相及峰值,探讨SH-VC控制性失血处理对HIR损伤的影响。

METHODS: Rat 35 min total hepatic ischemia model was used in this study. We treated the experimental rats by posthepatic manipulative bleeding or IH-CV manipulative bleeding at 10 min after reperfusion.

用大鼠HIR损伤模型,在再灌注后的10min分别在肝上下腔静脉及肝下下腔静脉进行控制性失血处理,观察其对HIR所致肺损伤的影响。

The higher the infusion pression is, the better the results of casting vessels are.

灌注时管腔内的压力越大,铸型的血管充盈越好。

In ischemia-reperfusion injury and acute myocardial infarction animal models,inhibition of prolyl hydroxylases has been observed to prevent deleterious remodeling and to attenuate the acute inflammatory response.

在缺血再灌注心肌损伤和急性心肌梗死的动物模型中发现,DMOG能够发挥降低大鼠的心肌重构和抑制炎症反应等保护作用。

Methods Fifteen cadaveric heads were taken in this study. The arteries and veins of the heads were perfused with red and blue latex, respectively, for simulating pterion approach under microscope. The spatial relationship between the anterior segment of basal vein and the operation space was examined. The cranium was then removed, the basal vein and its branches were observed and measured in the free brain.

取15具(30侧)尸头标本,动、静脉分别用红、蓝色乳胶灌注,在显微镜下模拟翼点手术入路,分别从手术中常用的间隙进行操作,观察基底静脉前段与手术间隙的关系。

Methods 10 adult arms were pured latex into artery microanatomized and observed the dorsal branch of anterior interosseous artery's originate、diameter、length and distribution of skin branch and periosteum branch.

10侧成人上肢标本经肱动脉灌注乳胶后,对其骨间前动脉背侧支的起始部位、口径、长度及其皮支、骨膜支的分布进行显微解剖观察。

OBJECTIVE To determine whether the protection of rutaecarpine against myocardial ischemia-reperfu-sion injury is related to the activation of capsaicin-sensitive sensory nerves in rats.

目的 观察吴茱萸次碱对大鼠心肌缺血再灌注损伤的保护作用是否与激活辣椒素敏感的感觉神经有关。

rutaecarpine pharmacological effects and its related mechanism: rutaecarpine the heart positive inotropic, positive changes in the role and the heart protective effect, which with its promotion of calcitonin gene-related peptide release; rutaecarpine alkali have vasodilative and hypotensive effect, its mechanism mainly related to endothelial cells Ca2 +-NO-cGMP pathways and calcitonin gene-related peptide release; rutaecarpine to relax the anal sphincter, gastrointestinal motility inhibition of stress ulcer and ulcerative colitis have therapeutic effect; rutaecarpine on cerebral ischemia-reperfusion injury has a protective effect, which instead of increasing the concentration of calcitonin gene-related peptide-related; rutaecarpine inhibits platelet aggregation and arterial thrombosis; In addition, rutaecarpine Alkali also anti-inflammatory and analgesic, anti-tumor and other pharmacological effects.

综述了吴茱萸次碱的药理作用及其相关机制:吴茱萸次碱对心脏有正性肌力、正性变时作用和心脏保护作用,这与其促进降钙素基因相关肽释放有关;吴茱萸次碱有扩血管和降压作用,其机制主要涉及内皮细胞Ca2+-NO-cGMP途径和降钙素基因相关肽的释放;吴茱萸次碱能松弛肛门内括约肌,抑制胃肠运动,对应激性溃疡和溃疡性结肠炎也有治疗作用;吴茱萸次碱对脑缺血再灌注损伤有保护作用,这与其增加降钙素基因相关肽浓度有关;吴茱萸次碱能抑制血小板聚集和动脉血栓形成;此外,吴茱萸次碱还有抗炎镇痛、抗肿瘤等药理作用。

Observed the expression of Ps and ICAM-1 at 1, 6, 12 hour during normoxia, hypoxia and reoxygenation respectively and the effect of serum safflor injection on the expression of Ps and 1CAM-1 mRNA after reoxygenation.

目的观察含红花血清在缺氧复氧条件下对大鼠肺动脉内皮细胞P-选择素及细胞间黏附分子-1(ICAM-1)基因表达的影响,探讨肺栓塞溶栓后缺血再灌注损伤的机制。

Effections of MB on hemodynamics and oxygenation of multiple splanchnic organs were observed in our study at first.

通过本研究观察MB对感染性休克血液动力学、内脏器官灌注和氧合、多器官功能的影响,探讨MB治疗感染性休克的可行性。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

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