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APT070, a novel membrane-targeted complement regulator can prevent ischemia/reperfusion injury and facilitate short term renal function in rat isograft model.

APT 070作为一种可与肾脏组织结合的新型补体抑制剂,可减轻肾脏缺血再灌注损伤。

Methods48 Wistar male rats were randomly divided into control, I/R group, high-, medium- and low-dose PLF groups, and verapamil group. The isolated perfused rat hearts were set up by Langendorff-perfusion system.

方法48只Wistar雄性大鼠随机分为正常对照组,心肌缺血再灌注组,PLF高、中、低剂量组,阳性药对照组。

Jugular vein blood and milk of both udders were taken immediately before and at 3, 6, 9 and 24 h after infusion and correlated enzymes and cytokines were measured to observe their changes.

灌注的第0、3、6、9、24h分别采集颈静脉血和左右两侧乳房的乳汁,对采集的血清和乳汁中相关酶活性和细胞因子含量进行测定,观测其动态变化规律。

Results Transient myocardial ischemia/reperfusion induced obvious accumulation of KEF 4 mRNA in rat. Oxidative stress distinctly raised the KLF 4 mRNA and protein levels in C2C12 cells.

结果 短暂缺血再灌注后,大鼠心肌组织中Krüppel样因子4mRNA的水平明显增加;过氧化氢处理C2C12肌原细胞后,Krüppel样因子4mRNA和蛋白的水平均明显增加。

The hypertension model rats were induced with bi-kidney-bi-clip method, then the focal cerebral ischemia-reperfusion rat model was induced by reversible occlusion for a middle cerebral artery with a thread on the stroke prone renovascular hypertensive model rat. While the rats in sham operation group were operated without thread insertion. Shuigou (Du 26), bilateral Neiguan(PC 6) and bilateral Housanli (Zusanli, ST 36) were located according to"Atlas of Experimental Animal Acupoints" made by Hua's. Shuigou (Du26): 1 mm below nasal apex right on the Labium leporinum, be punctured 1 mm obliquely upward; Neiguan (PC 6): at the lateral palm of the forearm3 mm above wrist joint, between ulna and radius, be punctured 1 mm perpendicularly; Housanli (Zusanli, ST 36): under knee joint, 5 mm below the capitulum of fibula, be punctured 7 mm perpendicularly. The skin of Shuigou (Du 26) and the root of right ear, Neiguan (PC 6) and Housanli (Zusanli, ST 36) were connected with electroacupuncture Therapeutic Instrument G6805 with the parameters of continuous wave, 120 times/minute in frequency, 1 mA in intensity for 30 minutes.

用双肾双夹法复制易卒中型肾血管性高血压模型,在此基础上,运用栓线法制备大鼠局灶性脑缺血再灌注模型;假手术组除不插入栓线外,其余步骤同模型组;电针治疗组取水沟(唇裂鼻尖下1 mm正中处,向上斜刺1 mm)、双侧内关(前肢内侧,离腕关节约3 mm处的尺桡骨缝间,直刺1 mm)、双侧足三里(膝关节下侧,在腓骨小头下约5 mm处,直刺7 mm)水沟穴与右耳根部皮肤、内关与足三里接G6805电针治疗仪,连续波,频率120次/min,强度1 mA,留针30 min。

Methods 61 cases of large intestine cancers were analyzed retrospectively.

目的 探讨5-Fu在肠系膜下动脉灌注中的不良反应。

Four beef catties with rumen, duodenum and ileum cannulars were used in a 4×4 Latin square experiment design.

通过瘤胃补充RPLys及十二指肠灌注赖氨酸研究了赖氨酸的保护和利用效果。

Objective:To study the clinical effect of thermo lavation chemotherapy after operation of stomach carcinoma.

目的:探讨胃癌术后早期腹腔热灌注化疗的临床效果。

Objective: To study the relative factors which influence the embolic level of microspheres in the hamster lingual carcinoma.

影响微球栓塞平面的因素有微球的大小、靶区组织的血管分布状况以及灌注途径和方法等。

Multiparameter imaging using maps of CBF, cerebral blood volume, and a time parameter of the local bolus transit enables analyzing of the cerebral perfusion status in detail.

多用地图血流成像、脑血容积一时间参数的分析,使当地的交通丸脑灌注详细状况。

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