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The contrast material was bolus injected through antecubital vein ,while four layers of dynamic scans were performed for 50 seconds.These slice dynamic images were processed with the CT perfusion software package.Cerebral blood flow,cerebral blood volume,and mean transit time were measured within the specific regions of interest of the brain,and quantitative analysis was performed.

在常规轴面CT扫描后选取基底节及其相邻层面,经肘静脉团注对比剂,同时开始连续50 s的四层动态扫描,重建的198幅动态图像使用CT脑灌注软件包进行处理,获得灌注图像,测量所选脑内感兴趣区的血流量、血容量及平均通过时间,并对其进行定量分析。

Objective To provide an anatomical basis for selecting optimal retrograde cardioplegia technique therefore to improve the effect of the operation.

目的为临床选择逆行灌注的操作技术及提高灌注效果提供解剖学依据。

Stenosis of internal caroid antery was found in 32 of 48 branches in 24 case. 5 branches were occlusive and 11 branches were normal. 22 cases with large or moderate cerebral infarction volume (>5 cm3) confirmed by CT and MRI were smaller than those on MSCTPI as having abnormal perfusion lesions,which were moderate and obvious stenosis and occlusion on MSCTA. In 2 cases with small cerebral infarction volume(<5 cm3), MSCTPI and MSCTA revealed normal.

其中32支颈内动脉呈不同程度的狭窄,5支颈内动脉闭塞,11支血管无狭窄。22例在常规CT及MRI图像上为中及大体积梗死(>5 cm3)的患者,MSCTPI发现与梗死灶相对应的异常灌注区,且均比常规CT及MRI图像上病灶体积大, MSCTA显示颈内动脉呈中重度狭窄或闭塞。2例未发现明显灌注异常的患者,为小体积梗死灶(<5 cm3),MSCTA显示颈内动脉正常。

Stenosis of internal caroid antery was found in 32 of 48 branches in 24 case. 5 branches were occlusive and 11 branches were normal. 22 cases with large or moderate cerebral infarction volume (>5 cm3) confirmed by CT and MRI were smaller than those on MSCTPI as having abnormal perfusion lesions,which were moderate and obvious stenosis and occlusion on MSCTA.

其中32支颈内动脉呈不同程度的狭窄,5支颈内动脉闭塞,11支血管无狭窄。22例在常规CT及MRI图像上为中及大体积梗死(>5 cm3)的患者,MSCTPI发现与梗死灶相对应的异常灌注区,且均比常规CT及MRI图像上病灶体积大, MSCTA显示颈内动脉呈中重度狭窄或闭塞。2例未发现明显灌注异常的患者,为小体积梗死灶(<5 cm3),MSCTA显示颈内动脉正常。

At each time point, we observed morphological changes, in situ detected DNA breaks, and observed expression changes of production of lEGs c-Fos and DNA repair enzyme APE/Ref-1 which participated in many kinds of DNA repairs. Results in the experiment were shown as follow:DHE stain indicates: The model of rat MCAO/R was credible, and the damaged regions included cortex (lobus frontalis, lobus arietalis, lobus occipitalis et al and caudatum.

本次实验采用大鼠大脑中动脉阻塞再灌注模型,将健康雄性SD大鼠随机分为正常组、假手术组和MCAO2h再灌注2h、6h、12h、24h、48h、72h组,观察各时间点损伤区域神经元和细胞的形态学变化,原位检测DNA断裂损伤,检测DNA修复酶APE/Ref-1表达变化情况以及IEGs产物c-Fos表达变化情况。

Blood samples were collected daily before and after infusion for assaying plasma IGF-1 levels and studying dynamic variations in plasma IGF-1, and effects of cholic acid on t...

灌注前和灌注后每天定时采取血样,测定血浆IGF -1水平,研究绵羊围产期血浆IGF -1的动态变化及胆酸负荷对其的影响。

At endpoint, every cardiac function parameter in group MSCs and TXL was not significantly different compared with group control (all P>0.05), however, the number of dyskinetic segments (P=0.039) and infarcted size (P=0.0061) in group simvastatin, and the number of dyskinetic segments (P=0.04) in group atorvastatin, were remarkably decreased compared with group control.

终点时,MSCs组、通心络超微粉组和对照组无显著差异(47.3±13.2%,44.8±13.9%vs 47.8±11.1%,P>0.05),而辛伐他汀组和阿托伐他汀组灌注缺损面积均小于对照组(39.3±12.4%,38.7±13.1%vs47.8±11.1%,P<0.05);尤其是通心络超微粉+MSCs组、辛伐他汀+MSCs组、阿托伐他汀+MSCs组的灌注缺损面积进一步显著减小(27.6±7.4%,28.3±7.7%,29.3±9.0%vs 47.8±11.1%,P<0.05)。

Results Both doses of SM and bFGF pretreatment before I/R, decreased the MDA, increased the activities of SOD and GSHpx, evocate levels of GSH and NO.

结果 bFGF和SM联合预处理组心肌中SDH、SOD、GSHpx活性明显高于缺血再灌注组,抗氧化物GSH和NO的含量明显高于缺血再灌注组,心肌病理改变明显好于未用bFGF和SM组。

Objective To investigate the effects of Gentiana water extract on the heat shock protein 70 expression in global cerebral ischemia-reperfusion injury in rabbits.

目的 观察秦艽水煎液对家兔全脑缺血再灌注损伤模型热休克蛋白70(HSP70)表达的影响,探讨Gentiana water exact 对全脑缺血再灌注损伤的保护机制。

Reperfusion Injury ;; Chemical Compositions;; Gerbillinae ;; Brain Ischemia ;; Reperfusion ;; CA1 Region, Hippocampal

灌注损伤;;中药化学成分;;沙鼠亚科;;脑缺血;;再灌注;; CA1区,海马

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