灌

Objective:To explore the relation of delayed neuronal death with neuronal apoptosis following transient forebrain ischemia in the gerbil.

目的：探讨脑缺血再灌后迟发性神经元死亡与细胞凋亡的关系。

But in his house the furniture was ghoulishly mutating and spinning, and the neighbour who brought him milk as an antidote was "a witch with a coloured mask".

但一进家门，那些不断变异和旋转的家具如同食尸鬼般朝他扑来，拿牛奶作解毒剂猛灌他的邻居也被当作是"戴着彩色面具的女巫"。

There is no significouldt variation between the function of Method 1 and 3 in the indexes of digestive and absorptive function,except the effect on body weight and food intake;as well,model 2 shows no significouldt influence on the indexes besides body weight lose.1.4 ConclusionsContrast the three modeling methods,model 3 is the most obvious and steady method for the establishment of deficiency of spleen YANG.2 comparison on the efficacy of Lizhong Pills influenced by dried ginger and its different components on digestive and absorptive functions and energy metabolism2.1 ObjectivesThis research was designed to observed the different influences of Lizhong Pills formula on the models,which contains dried ginger or its main group of components(volatile oil and water solubles).It would be explored from two levels of material base,single herb dried ginger or its different components,to confirm that the whole effects of Lizhong Pills do mainly depend on its main herb dried ginger in the formula just as the traditional acknowledgement in TCM.Further more,the connotative meaning of dried ginger used as the main herb in Lizhong Pills egthe aspect of pharmacology and chemistry would be preliminary revealed.2.2 MethodsEach group of model rats of deficiency of spleen-YANG were to be duplicated by method 3 for 14 days,and be treated by corresponding drug samples for 8 days.

造模方法1对消化吸收相关药理指标的改变与造模方法3的影响相似，但对模型动物的体重和食量的影响不明显；造模方法2除能使模型动物的体重减轻外，对其他各指标均无显著影响。1.4结论对比实验采用的三种石膏-知母的给药方法，方法3的造模效果最为显著和稳定，即以每日灌胃给药，连续12天，恢复9天，是本实验证实的最有效的脾阳虚证候模型制备方法。2干姜及其不同有效部位对理中丸消化吸收功能及代谢的影响2.1目的通过对理中丸中君药干姜，以及干姜中挥发性成分和水溶性成分对理中丸主要功效影响的研究，从药味和化学成分群两个层次，证实君药干姜及干姜中的主要活性成分群对理中丸整体功效的决定性影响，以初步揭示理中丸中君药核心地位的药理学和化学内涵。2.2方法采用石膏-知母复合造模法制备大鼠脾阳虚证候模型，造模期为14天1；治疗期间各给药组分别给予治疗药物，连续给药8天。

Experiment 3: Affections of Ginger Extraction on Cardiac Systolic/Diastolic Function of Rabbits with Heart Failure and the Comparison Between Ginger Extraction and 4-Retro-decoction (Si-hi Tang,四逆汤) Method 50 pure-breed New-Zealand rabbits were randomly allocated into 5 groups: control group, low (0.028mL/kg), middle (0.056mL/kg) and high (0.112mL/kg) dosage Ginger group, and 4-Retro-decoction group. The heart failure model of rabbit was established by intravenous administration of 20g/L pentobarbital sodium (0.15 mL·kg〓·min〓) at a certain rate. Oral tube perfusion of Ginger extraction was administrated after the establishment of the model. Their hemodynamic changes were detected before and after the model establishment, and at 5, 10, 15, 20, 30, 45, 60, 90, 120, 150 minutes respectively after the ginger administration by a RM-6000 4-graph physiological monitor.

干姜提取物对兔急性心衰模型心脏功能及血流动力学的影响及其与四逆汤作用的比较方法以50只纯种新西兰兔为研究对象，随机分为低、中、高剂量干姜组，溶剂对照组和四逆汤对照组，共5组，以0.15mL·kg〓·min〓静脉恒速给予20g／L戊巴妥钠的方法建立兔急性心力衰竭模型，造模成功后，经口插管入胃灌服受试品，用RM—6000四道生理仪测定造模前、造模成功时及用药后5min、10min、15min、20min、30min、45min、60min、90min、120min、150min兔的心肌舒缩性能指标，观察各时段指标的变化情况。

Methods 40pure-breed New-Zealand rabbits were randomly divided into4groups:low（0.028mL/kg）,middle（0.056mL/kg）,high（0.112mL/kg）dosage ginger group and4-Retro-decoction group.The heart failure model of rabbit was established by intravenous administration of20g/L pentobarbital sodium at a certain rate.Oral tube perfusion of ginger extract and4-Retro-decoction were administrated after the establishment of the model.Their hemodynamic changes were detected before and after the model establishment,and at5,10,15,20,30,45,60,90,120,150minutes respectively after the ginger administration by a RM-6004-graph physiological monitor.

以40只纯种新西兰兔为研究对象，随机分为高、中、低剂量干姜组和四逆汤组共4组，用恒速滴注戊巴比妥钠的方法建立兔急性心力衰竭模型，造模成功后，经口插管入胃灌服受试品，用RM-600四道生理仪测定造模前、造模成功时及用药后5min、10min、15min、20min、30min、45min、60min、90min、120min、150min兔的心肌舒缩性能指标，观察各时段指标的变化情况。

Objective To investigate the difference between the effects of Ginger Extract and4-Retro-deˉcoctionon cardiac systolic/diastolic function of rabbit with heart failure.Methods 40pure-breed New-Zealand rabbits were randomly divided into4groups:low（0.028mL/kg）,middle（0.056mL/kg）,high（0.112mL/kg）dosage ginger group and4-Retro-decoction group.The heart failure model of rabbit was established by intravenous administration of20g/L pentobarbital sodium at a certain rate.Oral tube perfusion of ginger extract and4-Retro-decoction were administrated after the establishment of the model.Their hemodynamic changes were detected before and after the model establishment,and at5,10,15,20,30,45,60,90,120,150minutes respectively after the ginger administration by a RM-6004-graph physiological monitor.

目的 探讨干姜提取物和四逆汤对心衰兔心脏舒缩性能的作用异同方法以40只纯新西兰兔研究对象，随机分为高、中、低剂量干姜组和四逆汤组共4组，用恒速滴注戊巴比妥钠的方法建立兔急性心力衰竭模型，造模成功后，经口插管入胃灌服受试品，用RM-600四道生理仪测定造模、造模成功时及用药后5min、10min、15min、20min、30min、45min、60min、90min、120min、150min兔的心肌舒缩性能指标，观察各时段指标的变化情况。

This paper is mainly comprised of two components:preparation of models of rats suffering from deficiency of spleen Yang;comparison of the pharmacodynamics impacts of different Lizhong Pills formulations made up by dried ginger or its different components in Lizhong Pills to the different groups of the models.1 Establish the model of deficiency of spleen YANG induced by " cypsum fibrosum and anemarrhenae " with complex factors1.1 ObjectivesWith using heat-clearing and fire-purging drug cypsum fibrosum and anemarrhenae,insteading of the common usage of rhubarb and folium sennae,accompanied with irregular diet and overstrained,the model of deficiency of spleen-YANG is to be established,which is much close to the pathopoiesis theory of " frigidity and chilly damaging yang,irregular diet injuring qi,overstrain impairing the spleen" in TCM.1.2 MethodsModel rats is fully fed every other day,given the molding drug of cypsum fibrosum -anemarrhenae(concentration 4:1) with 3 different frequency,and arranged to swim everyday in 25℃water until exhausted(performing as spitting bubble 3 times continuously or sinking unable to float by itself).

全文共分为脾阳虚模型的制备和干姜及其成分对理中丸药效学影响的比较两大部分。1"石膏-知母"复合法脾阳虚模型的制备1.1目的以清热泻火药石膏-知母代替常用的大黄、番泻叶类苦寒泻下药，并结合饥饱失常、劳倦过度的方法进行造模，以期建立更符合中医"寒凉伤阳、饥饱伤气和劳倦伤脾"致病思路的中医脾阳虚证候模型。1.2方法模型动物隔日足量喂食，每日在25℃水中游泳，直至大鼠连续三次吐泡下沉，或沉入水底，3秒内不能自行浮出水面，并以三种不同给药频率灌胃给予石膏一知母煎液，比较石膏-知母不同给药方法对制备脾阳虚模型的影响。

Seeing it, he poured out and drank another glassful .

看明白了这一点，他又倒了一杯酒灌下去。

Urine red blood cell count, 24 hour urine protein quantitation, serum creatinine and blood urea nitrogen were examined, the renal morphological changes under microscopy and ultrastructure under electron microscope were observed. immunofluorescence was applied to unveal the immunological damag on glomerule of kidney.

以 sd 大鼠为实验动物，通过一侧肾切除，反复尾静脉注射葡萄球菌肠毒素 b 的方法，制作 iga 大鼠肾病肾小球硬化模型。1 周后，同时予以鬼箭羽水煎液灌胃治疗为中药组，苯那普利为西药对照组，从而观察生化指标、病理改变。

Day was at hand. I lit my lantern, and by its glow-worm light put on my boots and gaiters; then I broke up some bread for Modestine, filled my can at the water tap, and lit my spirit lamp to boil myself some chocolate.

天快亮了。我点上灯笼，借助着它的萤火虫般的微光穿上我的长靴和绑腿；然后给Modestine撕了几片面包，在溪石的水柱边灌满了水，点燃酒精灯煮了几块巧克力。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。