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We thus hypothesized that increased TGF-beta signaling may contribute to the multisystem pathogenesis of MFS, including the development of myxomatous changes of the atrioventricular valves.

研究者使用抗游离和激活型TGF-β的单克隆抗体观察到,突变型小鼠二尖瓣叶内的免疫激活性增加,&表明TGF-β的激活而不是细胞因子的生成增多&。

A23187 and OA could parthenogenetically activate Urechis unicinctus oocytes and activate MAPK, indicating that the effect of fertilization on GVBD and activation of MAPK was mediated by rising in intracellular free calcium, and phosphorylation of some proteins was enough to activate the oocytes.

钙离子载体A23187和OA可以孤雌活化单环刺螠卵母细胞并激活MAPK。说明:①受精是通过钙离子的内流来激活卵母细胞并使MAPK活化的。②某些蛋白质的磷酸化状态对减数分裂是必要而且在一定程度上是充分的。

RESULTS: The right superior temporal gyrus (BA22), left medial frontal gyrus (BA46), followed by right and left postcentral gyrus of parietal lobe (BA2, BA3), left inferior frontal gyrus (BA45) and left inferior parietal lobule (BA40) were evoked by acupuncture at Taixi, but there was no activeation area after untwisting acupoint.

结果:捻转刺激太溪穴主要激活了右侧颞上回BA22,左侧的额中回BA46,其次为左右顶叶的中央后回BA2,BA3,左额叶的额下回BA45和左顶叶的顶下小叶BA40;而非捻转刺激则没有激活。

Expression rate induced by thrombin was 50.88% and PAC?1 re?expression was 54.55%. It is concluded that the ability of recovered lyophilized platelets added with reversible activation?inhibitors, DMSO and trehalose to aggregate and coagulate has showed no significant difference as compared with FPRP. The reversible activation?inhibitors can decrease CD62p expression of lyophilized platelets, and may enhance their survival ability and prolongate survival time. Therefore the efficiency of lyophilizing platelets can be improved based on this freeze?drying procedure.

添加血小板可逆性激活抑制剂,海藻糖和DMSO后的冻干血小板,其聚集活性和促凝血功能与新鲜血小板无明显差异,血小板可逆性激活抑制剂降低了冻干血小板的CD62p表达,增强了冻干血小板的生存能力,因而延长了其生存时间,因此可以该冻干方法为基础进一步提高冻干保存血小板的效率。

CD62p reexpression rate induced by thrombin was 50.88% and PAC1 reexpression was 54.55%. It is concluded that the ability of recovered lyophilized platelets added with reversible activationinhibitors, DMSO and trehalose to aggregate and coagulate has showed no significant difference as compared with FPRP. The reversible activationinhibitors can decrease CD62p expression of lyophilized platelets, and may enhance their survival ability and prolongate survival time. Therefore the efficiency of lyophilizing platelets can be improved based on this freezedrying procedure.

添加血小板可逆性激活抑制剂,海藻糖和DMSO后的冻干血小板,其聚集活性和促凝血功能与新鲜血小板无明显差异,血小板可逆性激活抑制剂降低了冻干血小板的CD62p表达,增强了冻干血小板的生存能力,因而延长了其生存时间,因此可以该冻干方法为基础进一步提高冻干保存血小板的效率。

Results Based on the analysis of the number and lightness of DGGE bands, we studied the change of the microbial community diversity activation of stratal bacteria.

通过对内源微生物激活前后DGGE条带的数量和亮度变化分析表明,油藏环境中的细菌在种类和数量上并不丰富,激活剂的加入改变了菌群原有的贫营养环境,从而使一些因营养缺乏生长受抑制细菌得以大量繁殖,菌群结

Immunostimulatory sequence (155), unmethylated CpG dinucleotides in particular base contexts, are relatively common in bacterial DNA but rare in vertebrate DNA, and can be detected as an infectious danger signal by the vertebrate innate immune system.

DNA免疫激活序列(immunostimulator sequence,ISS)是发现于细菌DNA 中的一些以未甲基化的 CpG二核苷酸对为核心的具有免疫激活功能的核苷酸序列。

Under current-clamp mode,'depolarizing sag'was observed in all neurons with Ih current.

激活时间常数τ与神经元的大小负相关,也就是说大细胞上的Ih电流的激活速率要比小细胞上的快。

A new model is presented for the physically-consistent description of plastic instabilities referred to PLC effect. The model takes account of two competing processes during the DSA on micro-scale: the additional pinning of diffusing solute atom on mobile dislocations and the unpinning of the mobile dislocation with the aid of thermal activation.

建立了一个基于动态应变时效过程中热激活机制和二阶应变梯度空间耦合方式的宏观唯象模型,该模型刻画了材料内部在微细观尺度上彼此协同和相互竞争的两个过程:溶质原子对可动位错的时效钉扎和可动位错在热激活辅助下的挣脱。

It is now generally accepted that interactions between ligand-receptor complexes and cofactors are essential for AR function, selectivity, sensitivity, and may contribute to the progression of prostate cancer.

我们应用PKC激动剂PMA对AR进行的研究表明,PMA对野生型AR和AR突变体均有基本相同的配体依赖性转录激活作用,并且还与DHT一起,对野生型AR及AR突变体的转录激活起协同的作用。

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The objective is to subjugate and discourage the people, because that allows the elite to continue to rule unopposed.

其目的是压制和打击人民的积极性,因为这可以让实权派继续统治不会沦为反对派。

GOD,this is the second time you vanquished me!

天啊,这是第二次你打败了我!

So a kind of strong antagonism permeated in the relations of two countries.

所以两国这一时期的政治关系始终弥漫着一种强烈的对抗情绪。