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objective to invetigate the variations of plasminogen activator inhibitor-1(pai-1) and tissue-type plsminogen activator in patients with diabetic nephropathy.

目的 探讨2型糖尿病(t2dm)患者血浆纤溶酶原激活物抑制物(pai-1)和组织型纤溶酶原激活物活性水平的变化及其与糖尿病肾病的关系。

The transformation growth factor-β pathway in the CM was activated.

激活CM中的TGF-β途径,MTT法测定TGF-β途径被激活前后细胞的增殖变化。

As noted above,membrane-stabilizers unexpectedly improved the heart function andprevented ER stress both in vivo and in cultured cells.We know that the membranestability depends on the sodium homeostasis in fact.To investigate whether ER stress isassociated with sodium channel action,which determins the membrane stability,wepretreated H9c2(2-1) cells with veratridine,a sodium channel activator.

上面的研究发现膜稳定剂在体内体外均抑制了内质网应激,并改善了心脏功能,而膜稳定作用实际上是维持细胞钠离子稳态的结果,为了研究内质网应激反应与钠离子活动的关系,我们用一种钠通道激活剂藜芦定刺激H9c2(2-1)细胞,30分钟时GRP78表达增加;24小时时PERK磷酸化和CHOP蛋白表达显著增加,说明钠离子通道过度激活诱发了内质网应激反应。

However, dexamethasooe did not seem to affect the sustained current and the sustained component of the biphasic current induced by ATP. The in hibitory effect of dexamethasonc on ATP induced currents was blocked by glucocorticoid receptor antagonist RU38486 (10μmol/L) and protein kinase A inhibitor H-89 (10μmol/L), but not by G protein inhibitor GDP-β-S (0.2mmol/L) and protein kinase C inhibitor chelerythrine chloride (10μmol/L).

地塞米松对ATP激活电流的快速抑制作用可被糖皮质激素受体拮抗剂RU38486(10μmol/L)、蛋白激酶A抑制剂H-89(10μmol/L)阻断,而G蛋白激活抑制剂GDP-β-S(0.2mmol/L)、蛋白激酶C抑制剂Chelerythrine chloride(10μmol/L)对地塞米松的快速抑制作用无明显影响。

Expression of copCD is regulated directly by the two-component response regulator CopR, which also regulates its own expression.

双元调控系统中的调控蛋白CopR不仅激活copCD表达,而且还激活copRS的表达。

Through activating the synthesis of jasmonic acid itself,aboveground application of jasmonia acid could induce the expression of Bx1,Bx9,PAL,PR-1,MPI,FPS and TPS genes,increase DIMBOA content and decrease caffeic acid content in leaves;on the other hand,the systematic induction of gene expression of Bx6,Bx9、PAL and PR-2a,increase of contents of coumaric acid and caffeic acid,and decrease of syringic acid content in the roots were related with the activating of jasmonic acid synthesis in the aboveground.

茉莉酸处理地上部是通过激活茉莉酸自身合成来诱导叶片Bx1、Bx9、PAL、PR-1、MPI、FPS和TPS基因的表达、增加叶片丁布含量及降低咖啡酸含量的,同时系统诱导根系Bx6、Bx9、PAL和PR-2a基因表达、增加香豆酸和咖啡酸含量以及降低丁香酸含量则与激活地上部茉莉酸自身合成相关。

At the neural level, Experiment 1 revealed a set of brain regions, including bilateral superior and inferior frontal eye fields, intraparietal sulci, supplementary eye field, regions in the junction between transverse occipital sulci and intraparietal sulci, and anterior insular were activated more when the display was heterogeneous than homogeneous.

在神经活动上,相对于干扰项同质条件,双侧上部和下部额叶眼区、辅助运动眼区、顶间沟、顶枕联合、以及前脑岛区域在干扰项不同质时显著激活;干扰项同质性与目标存在性的交互作用在大脑中表现出两组激活模式不同的脑区。

Treatment with dopamine and low dose bromocriptine resulted in cell death accompanied with the DNA laddering and activation of caspase-3 only in GH3D2L and GH3D2S cells, which were blunted by haloperidol, showing that dopamine-induced cell death in these cells is mediated by dopamine D2 receptors.

经多巴胺和低浓度溴隐亭处理后仅在GH3D2L和GH3D2S两种细胞中出现细胞死亡伴DNA阶梯状断裂和半胱天冬酶3(Caspase-3)的激活,而这些效应也被氟哌啶醇所抑制,说明多巴胺所致的细胞凋亡与多巴胺D2受体激活有关。

(1)The AEMG of extension are higher than flexion, suggesting that concentric exercise are stronger activation than eccentric exercise;(2)The activity pattern of lumbar multifidus existed contralateral enhancement effect during trunk axial rotation;(3)The high activation range of lumbar multifidus and erector spinae may be concentrated in the region of 45 °-65 ° angle.

单侧手持负荷且当负荷等级达到一定水平时,腰部竖脊肌和多裂肌的激活特征表现为对侧增强效应;背部负荷时腰部竖脊肌和多裂肌各自左右两侧的激活特征表现为对称效应。

When the activity of MAPK was sustained after electronic parthenogenetic activation, the activity of 〓 was also maintained.

放线菌酮不抑制GVBD的发生,但抑制MAPK的激活,此时〓也不被激活。

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The objective is to subjugate and discourage the people, because that allows the elite to continue to rule unopposed.

其目的是压制和打击人民的积极性,因为这可以让实权派继续统治不会沦为反对派。

GOD,this is the second time you vanquished me!

天啊,这是第二次你打败了我!

So a kind of strong antagonism permeated in the relations of two countries.

所以两国这一时期的政治关系始终弥漫着一种强烈的对抗情绪。