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Experiments show that Ang Ⅱ activates JNK mediated by AT〓, and JNK increases transcription activity of c-Jun by phosphorylating c-Jun amido-terminal, and induces expression of c-Fos gene. c-Jun and c-Fos form transcriptional factor activated protein-1 complex. AP-1 may stimulates genes which correlate with cardiovascular remodeling expression, such as transforming growth factor, collagen type Ⅰ and Ⅲ, skeletal muscle α-actin,β-MHC, atrial natriuretic factor.

实验表明,在心肌和血管平滑肌细胞Ang Ⅱ通过AT〓介导激活JNK;JNK通过磷酸化c-Jun氨基末端增加c-Jun的转录活性并诱导c-Fos基因表达,c-Jun和c-Fos蛋白形成转录因子复合物激活蛋白-1(AP-1),并刺激各种心血管重塑相关基因如转化生长因子-β1(TGF-β1)、Ⅰ,Ⅲ型胶原、骨骼肌α-actin、β-MHC(β-myosin heavy chain,β-肌球蛋白重链)、心钠素的表达。

Traditional theory of self-digestion of amylopsin can not explain the etiology, recently Rindernecht et al brought forward "The theory of excessive activation in white blood cell" to deal with the problem, the theory thinks when the AP occurs, white blood cell releases a lot of cell factors, such as TNF-α、IL-1、PAF、PG、LT et al.

传统的胰酶激活自家消化学说难以解释,近年来Rindernecht等提出的"白细胞过度激活学说"为解决这一难题提供理论基础。

If be in smooth and steady when making big money, leader and employee are OK before profit and welfare live in peace with each other, activation implication appears not quite; But now the situation wants a company again tighten chatelaine, important official work goes again desperately, everybody must want to say " be " or " not ".

如果在安安稳稳挣大钱的时候,领导者和员工在利润和福利面前都可以相安无事,激活不激活干系似乎不大;但而今的形势要企业再勒紧腰带了,要员工再去拼命了,每个人都必须要说"是"或者"不"了。

Unexpectly, overexpression of xNorrin can induce neural formation in the ectoderm cells independent of canonical Wnt signaling pathway.

此外,在外胚层中过量表达xNorrin可以激活神经标记基因的表达,更为重要的是这种激活并不依赖于经典Wnt信号通路,提示xNorrin还可能通过其它机制起作用。

The present study was conducted to investigate the effect of different culture systems, co-culture cells and their sequence culture on the in vitro development of porcine parthenogenetic embryos derived from in-vitro matured oocytes.

经体外成熟、孤雌激活和培养获得猪胚胎,研究了不同培养体系、共培养体细胞和序贯培养对猪孤雌激活胚胎发育的影响。

AIM: To investigate the effects of T cell activators on the mRNA expression of recombinationactivating genes in Jurkat cells.

目的:研究T细胞激活剂PHA,抗CD3 mAb, PMA+A23187对人T细胞白血病细胞株Jurkat重组激活基因mRNA表达水平的影响。

HSC may play an important role in the development and deterioration of liver fibrosis in diabetic tree shrews .

糖尿病树鼩早期肝纤维化中出现HSC激活现象,提示HSC激活在糖尿病早期肝纤维化的发生、发展中可能发挥重要作用。

The results show that the rudder angle of torpedo, the battery activation time, and the initial velocity of torpedo all affect the trajectory of torpedo. The rudder angle ought to be set positive when torpedo is launched downwards,or set negative when torpedo is launched upwards to gain perfect trajectory. Meanwhile, shorter battery activation time and higher initial velocity of torpedo are necessary.

结果表明,以上3个参数对鱼雷弹道都有影响,由小深度向大深度发射鱼雷时,横舵管制舵角应设为正值,由大深度向小深度发射鱼雷时,横舵管制舵角应设为负值,并尽量缩短动力电池激活时间,提高鱼雷出管速度,电动力鱼雷管外激活发射可获得较好的弹道。

Activations in some areas of the right hemisphere were found in two patients, which were not found in normal subjects.

有2位患者显示了右侧大脑半球某些区域的激活,而这些区域在正常志愿者中没有激活。

Two patients with DCDs demonstrated activation of basical cerebral regions such as Wemicke and Broca areas.

两例DCDs患者表现为基本语言功能区的激活,诸如Wemicke区和Broca区激活。

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The objective is to subjugate and discourage the people, because that allows the elite to continue to rule unopposed.

其目的是压制和打击人民的积极性,因为这可以让实权派继续统治不会沦为反对派。

GOD,this is the second time you vanquished me!

天啊,这是第二次你打败了我!

So a kind of strong antagonism permeated in the relations of two countries.

所以两国这一时期的政治关系始终弥漫着一种强烈的对抗情绪。