激活的

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用，PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化，从而减少脂质的异位沉积，进一步改善损伤的胰岛素信号转导通路，逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体；脂肪酸代谢；胰岛素抵抗

This language can be extended when components are well designed. By the introduction of a data type conversion function in the edge design and can-connect function in input terminal, the extended data flow language successfully solved the data conversion between different data types. It is a difficult problem in data flow language to realize conditional jump and recursion, however, by using the mechanism of active condition, this dissertation solves the problem well.

相比其它现有的数据流语言，扩展数据流语言具有以下特点：元件设计中定义了一种可激活函数，不同类型的节点允许定义各自的可激活条件，通过合理设计虚拟仪器元件，可以扩展语言的功能；在边的定义中引入类型转换函数，在输入端的设计中引入可连接函数，从而解决了不同数据类型之间数据传递的问题；在数据流语言中实现条件分支与循环通常是具有挑战性的一个问题，本文采用可激活函数的机制给出了一种解决方法。

It seemed thatthere was no significant difference between these two conditions.The brainmechanism of translation was investigated in Experiment 4.It was found that thecommon brain areas activated by the conversion from Chinese to English and thatfrom English to Chinese were the left gyrus frontalis medius and the gyrus fusiformis.

实验4考察了双语词汇的知觉表征之间进行转换的脑机制，发现中→英转换和英→中转换在脑区激活模式上存在差异，前者最大的激活区在额叶，包括双侧的额中回和左侧额下回，而后者最大的激活区在颞叶的颞中回中后部。

Though Pin1 does not influence the regulatory role of Axin in the Wnt signal pathway, Pin1 and Axin additively activate TGF-βsignaling.

随后我们发现虽然它们的相互作用并没有影响Axin对Wnt信号通路的抑制作用，但是Pin1和Axin对TGF-β信号通路的激活具有叠加效应，在293细胞中进行的荧光素酶报告基因实验表明Axin与Pin1能够协同激活p53蛋白的转录活性，为深入研究Axin激活p53的机制提供了新的思路。

During the BDST task, areas showing activation in healthy volunteers include bilateral middle frontal gyrus, left superior frontal gyrus, inferior frontal gyrus, precentral gyrus, superior parietal lobe, suprarnarginal gyrus, Inferior temporal gyrus and occipitotemporalis lateralis gyrus, however, the left superior frontal gyrus, inferior frontal gyrus and bilateral posterior parietal cortex in schizophrenic patients showed significantly less activation.

在＊M河的侧m检查中治疗后，IA亚组的左侧额上回及左侧额下口的激活低下明显改善（P＜O.05），H A亚组的左恻额上回及左侧额下回的激活低下明显改善P＜O刀5），右侧领下回的激活降低（P＜0.05）。结论门）首发精神分裂症患者在发病初期就存在认知缺陷症状，工作记忆等与前额区相关的功能缺陷是普遍而严重的。

ABSTRACT In order to study the thermally activated characteristics of plastic deformation and the effect of alloying element on the thermal activation of structural steels, the properties of plastic deformation for 20g and 13Ni3CrMoV steels have been examined in the temperature of 77—473K and strain rate of 〓. The experimental phenomena show that the effective stress of plastic deformation decreases with the increase of alloying elements content (namely solute solution softening) and the frequency factor deceases with the increase of effective stress.

本文以13Ni3CrMoV钢焊接结构的动态断裂破坏为背景，通过系统测试20g和13Ni3CrMoV钢的动态屈服特性，分析比较了结构钢的形变热激活特点，从频率因子〓随有效应力σ〓增大而下降和合金固溶软化的实验现象出发，在位错以弯折方式克服晶格Peierls位垒的基础上，提出了溶质原子与螺型位错热激活弯折相互作用的物理模型和σ〓-T分段线性关系的形变热激活理论假设，并借助计算机数值模拟，分析探讨了合金固溶软化的微观机制。

The results show that the surface layer of the air-exposed ZrVFe getter is covered with H20, CO2 and hydrocarbons, both Zr and V exist in the oxidized state, and vanadium oxide starts to reduce at 200℃. The activation results in the enrichment of Zr on the getter surface and the formation of the metallic carbides. H2O, CO2 and hydrocarbons sequentially desorb from the surface with the increase of temperature. H2 is the main gas which desorbs above 200℃ and O2 is not discovered. ZrO2 is reduced to near-metallic or metallic state because O in ZrO2 leaves the getter surface through diffusing into getter bulk.

结果表明：暴露于过大气的吸气剂表面覆盖着H2O、CO2及碳氢化合物等，Zr和V主要以氧化态存在；在吸气剂加热激活过程中，V的氧化物在200℃开始还原；激活过程导致表面近金属态Zr的富集以及部分金属碳化物的生成；随着温度的升高，H2O、CO2及碳氢化合物逐渐从吸气剂表面脱附，在200℃以上，主要脱附气体为H2，整个激活过程未发现O2；ZrO2还原为近金属态或金属态，主要是由于ZrO2中的O通过向吸气剂内部扩散而离开吸气剂表面所致。

MMPs are usually secreted as latent, inactive proenzymes, which need to be activated (Fig 1 ), and/or are bound to their native inhibitors, the tissue inhibitors of metalloproteinases.8 Activation may involve proteolysis and/or oxidation of the latent enzyme.8 Proteolytic activation of the proenzymes cleaves the propeptide sequence, which masks the active site of the latent enzyme.

金属蛋白酶常以无活性的酶原方式分泌，而后者要么需要被激活要么与附近的或组织中金属蛋白酶抑制物结合。激活作用包括了具有潜在酶的蛋白水解作用或氧化作用。酶原的蛋白水解激活作用能将掩盖活性部位的潜在酶的前肽序列破坏。

To investigate the function of Nogo-A in neurons, human embryonic kidney cell line 293FT was used as a model, along with the pathway profiling reporter system to check the involvement of Nogo-A in regulating the intracellular signaling pathway. It was found that over-expression of Nogo-A could activate NF-κB signaling specifically, then followed by using different Nogo-A alternative splicing isoforms and a serial of truncations, it was confirmed that the activation of NF-κB by Nogo-A relied on its N-terminal proline rich domain. Furthermore, by co-expressing the dominant negative mutants of some NF-κB pathway associated proteins, it revealed that the IκBα,TRAF6, Rac/Cdc42 were involved in Nogo-A inducing activation of NF-κB.

为探讨神经元内Nogo-A的功能，以HEK293FT细胞为模型，利用信号途径报告基因系统筛选过表达Nogo-A对多种信号途径的调控作用，发现过表达Nogo-A能特异激活NF-κB信号，利用不同的Nogo-A剪接体和截断体形式研究，证明Nogo-A激活NF-κB信号依赖于其氨基端的proline rich结构域，进一步使用NF-κB信号途径相关分子显性突变体揭示IκBα、TRAF6、 Rac/Cdc42 参与Nogo-A激活NF-κB信号。

To investigate the function of Nogo-A in neurons, human embryonic kidney cell line 293FT was used as a model, along with the pathway profiling reporter system to check the involvement of Nogo-A in regulating the intracellular signaling pathway. It was found that over-expression of Nogo-A could activate NF-KB signaling specifically, then followed by using different Nogo-A alternative splicing isoforms and a serial of truncations, it was confirmed that the activation of NF-kB by Nogo-A relied on its N-terminal proline rich domain. Furthermore, by co-expressing the dominant negative mutants of some NF-kB pathway associated proteins, it revealed that the IkBα,TRAF6, Rac/Cdc42 were involved in Nogo-A inducing activation of NF-kB.

为探讨神经元内Nogo-A的功能，以HEK293FT细胞为模型，利用信号途径报告基因系统筛选过表达Nogo-A对多种信号途径的调控作用，发现过表达Nogo-A能特异激活NF-kB信号，利用不同的Nogo-A剪接体和截断体形式研究，证明Nogo-A激活NF-kB信号依赖于其氨基端的proline rich结构域，进一步使用NF-KB信号途径相关分子显性突变体揭示IkBα、TRAF6、Rac/Cdc42参与Nogo-A激活NF-kB信号。

The objective is to subjugate and discourage the people, because that allows the elite to continue to rule unopposed.

其目的是压制和打击人民的积极性，因为这可以让实权派继续统治不会沦为反对派。

GOD,this is the second time you vanquished me!

天啊，这是第二次你打败了我！