激活

One hand mechanical obstruct led to the increase of veinous resistance and the obstacle of microcirculation, the other hand the adhesive PMN was activated in excess, the white blood cells released a lot of enzymes, in which PMN-elastase can decompose the components of cell and many albumens, inclusive of immunoglobulin、alexin and fibrication. These components induced the injury of the pancreatic capillary vessels and cell and lysosome enzy made the tissue protein hydrolyze and produced unsaturated fatty acids, which destroyed the structure and function of cellar membrane. The inflammatory cellar factors activate other immunocytes to produce the injury and necrosis of tissue, which aggravated the pathological injury and led to shock、pyaemia and MODS. So ICAM-1 and LFA-1 played an important role in SAP. Frossard found that the expression of ICAM-1 in the rat model, especially in serum、pancreas and lung. All these showed ICAM-1 is an important factor in AP and concomitant lung injury.

胰腺小叶组织局部血管EC首先被激活，ICAM-1表达升高，与被激活的PMN表面表达的LFA-1相结合，"PMN-EC"相互作用加剧，一方面机械性阻塞毛细血管导致静脉阻力增加、微循环障碍；另一方面粘附的PMN过度吞噬或激活，当白细胞吞噬的颗粒不能被封闭隔离，连同细胞内的酶被释放出来，其中的PMN-elastase能够降解细胞基质中各种成分，水解多种蛋白，加重胰腺的毛细血管内皮细胞和腺泡的损伤；释放的溶酶体酶使组织蛋白水解，产生的不饱和脂肪酸引发脂质过氧化方应，破坏细胞膜的结构和功能；释放的炎性细胞因子，激发其他的免疫细胞的功能，导致进一步的组织损伤和坏死，加重SAP的病理损伤，最终导致休克、脓毒血症及多器官功能障碍等严重后果。

Caffeine - A derivative of coffee, is an efficient arouser of central nervous system capable to drive away fatigue, and improve renal circulation. Its stimulation on the cerebral cortex activates Neurotransmitter receptors in the cell membrane; the adenylyl cyclaseactivated on the other surface of the cell catalyzes Adenosine Triphosphate, forming Cyclic adenosine monophosphate, and thus set off series of bio-chemical reactions, like increase of passionate feel, prompt recovery from fatigue after working etc..

咖啡因—由于咖啡本身具有兴奋神经中枢，消除疲劳，增加肾脏血流量的作用，通过对大脑皮层的刺激，使神经递质作用于细胞膜受体，激活了膜另一侧的腺苷酸环化酶，被激活的腺苷酸环化酶催化三磷酸腺苷环化酶，被激活的腺苷酸环化酶催化三磷酸腺苷形成环磷酸腺苷，从而引起一系列生化反应，如增加愉快感和消除事后疲劳等。

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用，PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化，从而减少脂质的异位沉积，进一步改善损伤的胰岛素信号转导通路，逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体；脂肪酸代谢；胰岛素抵抗

Results During Chinese reading, the activated areas included bilateral motor area, subfrontal gyri, superior temporal gyri, and superior parietal lobule; during English reading, the activated areas were left motor area, left subfrontal gyrus, left supra temporal gyrus, left insula and bilateral cerebellum; and the Nepali task demonstrated the activation of left anterior central gyms, superior frontal gyms, superior temporal gyms.

结果：除负责视觉活动的枕叶为双侧激活，汉语任务主要激活了双侧额上回、额中回、中央前回、顶上小叶、颞上回及颞中回；英语任务主要激活了左侧额上回、中央前回、顶上小叶、颞上回、颞下回及小脑；尼泊尔语任务主要激活了左侧中央前回、额上回及颞上回。

The results show that, under supraliminal condition, as for the depression patient, fusiform, inferior frontal gyrus and Gyrus parahippocampi were deactivated, and the midiel occipital gyrus was activated during processing negative word; BA10∥19/21/32/37//45/46/47 were deactivated during processing positive word; no brain area was involved in processing neutral word.

在有意识加工的条件下，抑郁症病人对消极词的加工引起了梭状回、额下回和海马旁回的去激活，同时引起了枕中回的激活，对积极词的加工引起了BAl0∥19/21/32/37∥45/46/47的去激活，而对中性词的加工没有引起脑区的激活。

Hideyuki Doi, Nakui Madaki, Hrroshi, Hiromichi Komatsu, Keisei Fujimori and Susumu Satomi Tohoku. A New Preadipocyte Cell Line,AP-18,Established from Adult Mouse Adipose Tissue. J.Exp.Med,2005,207:209-216[2] Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ 2, a lipid-activated transcription factor. Cell ,1994,79:1147－1156

PPARα调节脂肪代谢的机制总结如下：肝脏脂肪酸水平的增高激活PPARα，然后转录激活参与脂肪酸氧化的基因；配体与之结合后可激活编码乙酰辅酶A合成酶的基因，同时PPARα激活后可调节脂肪转运相关基因的表达如PPARα升高高密度脂蛋白和抑制ApoC－Ⅲ的表达。

Our study includes four aspects. In the first aspect we study several important conditions of porcine oocytes maturation in vitro and oocytes cleavage after parthenogenetic activation and found mNCSU-23+15IU/mlPMSG+20IU/mlHCG+15% PFF+0.57mMcysteine is a good culture condition .When the Cocs are cultured in it ,the maturation rate and oocytes cleavage rate are higher than those of foreign covered. Our result are (86.7±3.35)% and (86.3±4.16)% and the highest report of foreign is(85.7±4.1)%.In the second aspect we study the effect of different chemical activations on development of porcine parthennogenetic embryo and found two best activation method. The first one is that putting the maturation MII oocytes in the 20μmol/L ionomycin for 30 minutes and then putting them in the NCSU-23 condition containing 5μg/mICB and 5mM/L6-DMAP for 3.5 hours, the oocytes cleavage rate and morulae/blastocysts development rate are (76.7±7.6)% and (37.1±6.4)%.The second one is that putting the maturation MII oocytes in the 200μM/L Thimerosal for 20 minutes and then putting them in the NCSU-23 condition containing 8mM DTT for 30 minutes

本研究分为4个部分，第一部分对影响猪卵母细胞体外成熟和孤雌激活后胚胎分裂的几个重要条件进行了比较研究，确立了一种较好的培养方法：与颗粒细胞共培养，找到了一种适合猪卵母细胞体外成熟的培养基：mNCSU-23+15IU/mlPMSG+20IU/mlHCG+15%PFF+0.57mM半胱氨酸，成熟率和分裂率分别为(86.7±3.35)%和(86.3±4.16)%，国外报道的最高成熟率为(85.7±4.1)%；第二部分对猪卵母细胞孤雌激活的化学方法进行了研究，确立了化学激活猪卵母细胞的两种最佳方法：1将成熟的去卵丘颗粒细胞的MII期卵母细胞用20μmol/Lionomycin作用30min，再将卵母细胞培养于含5μg/mlCB和5mM/L 6-DMAP(6-二甲基氨基嘌呤)的NCSU-23培养液中，卵裂率和桑囊胚发育率达到(76.7±7.6)%和(37.1±6.4)%2将成熟的去卵丘颗粒细胞的MII期卵母细胞在200μM/L的Thimerosal中处理20min，再与8mM的DTT共孵育30min，卵裂率和桑/囊胚形成率为(81.0±2.8)%和(39.6±2.7)%；第三部分对孤雌激活胚胎的培养条件进行了研究，确立了一种最佳的胚胎培养条件：在SOF简单培养基中添加颗粒细胞进行前3天的培养，然后转入添加胎牛血清的NCSU—23培养基并和输卵管上皮细胞进行后期的培养，其桑椹胚和囊胚的发育率为(59.5±3.2)%；第四部分研究了IGF-I

It is essential for the activation of NADPH oxidase that p47〓, a cytosolic component of NADPH oxidase, is phosphorylated by PKC and translocates to the plasma membrane to form an active complex with other cytosolic components and the membrane oxidase subunits.

在PKC激活的同时，磷脂酰肌醇3-激酶（PI3-K）也被激活，PI3-K进一步引起蛋白激酶B激活，据研究认为Akt能够激活NADPH氧化酶，而且PI3-K还能够参与中性粒细胞的趋化作用。

In a word, these results indicate that there were no any difference of spatiotemporal cortical activation patterns underlying the early stage of insight problem solving between Aha logogriphs and No-aha logogriphs. In the process of activating heuristic information and then hastening the onset of insight, LPFC/ACC played an important role, which may be associated with the breaking of mental set successfully and the forming of novel associations in insight. The "Aha" feeling mainly provoked the PCC brain region in the solving the logogriph at last.

综合实验6与实验7的结果，我们认为，在字谜解决的早期，&有顿悟&与&无顿悟&字谜所诱发的脑电并没有明显的差异，原型激活可能主要发生在字谜解决的1400 ms左右，字谜的成功解决在1400-2000 ms内导致了左侧额中回／扣带前回的更强激活，这可能与原型激活以后，被试利用启发信息，突破思维定势，形成新异联系的认知过程有关；随后在2000-2500 ms内，字谜的成功解决则诱发了强烈的情绪体验，导致了扣带后回的明显激活。

Results showed that the activity of soil poly-phenol oxidases and acid phosphatase, and soil respiration were suppressed by Starane at 0.5 and 5 mgkg^(-1) dry soil, respectively, during the first several days of experiment, but were slight promoted thereafter. In contrast, treatment with Starane at 50 mgkg^(-1) stimulated at the beginning of experiment but inhibited following that time the activity of soil poly-phenol oxidases and acid phosphatase and soil respiration. Activity of urease was stimulated at the beginning but inhibited in the following days by Starane at 0.5 and 50 mgkg^(-1) dry soil, respectively. However, the pattern of stimulation of urease activity at first several days of experiment followed by reduction to the basil level was observed. With respect to invertase, its activity was constantly depressed in the presence of Starane.

结果表明使它隆在0.5mgkg^(-1)和5mgkg^(-1)质量分数时对土壤多酚氧化酶、酸性磷酸酶和呼吸强度的影响为轻微抑制－激活－恢复稳定的趋势，50mgkg^(-1)质量分数时为轻微激活－抑制－恢复稳定的趋势；使它隆在0.5mgkg^(-1)和50mgkg^(-1)质量分数时对土壤脲酶活性的影响为激活-恢复稳定的趋势，5mgkg^(-1)时则处于抑制－激活的趋势；各质量分数的使它隆浓度对土壤蔗糖酶和土壤全酚均为抑制作用，且质量分数越大抑制越强烈。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。