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潜伏期

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MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型,分析灌胃小鼠各药的量效和时效关系,比较其效价强度和效能;②采用戊四唑惊厥模型,比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率;③采用药效法,运用数学模式及参数来模拟各药在体内的药效动力学过程;④制备大鼠皮层定位注射青霉素点燃模型,采用RM6240C型多道生理信号采集处理系统记录脑电图,比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响;⑤采用HPLC法测定海马区癫痫相关递质的含量,比较各药对Glu、Asp、Gly、GABA的影响。

On the 3 rd day after operation, compared with group C, the latency period and swimming distance of group O, group Hup extended further, while compared with group O,the latency period and swimming distance of group Hup shortened (P.05);Compared with group C, the extending degree of the latency period and swimming distance of group O decreased on the 7 th day after operation.

结果 术后1 d进行水迷宫测试,与C组比较,A组、O组潜伏期和游泳距离均延长(P.05);术后3 d,与C组比较,O组、Hup组潜伏期和游泳距离进一步延长,而Hup组与O组比较,潜伏期和游泳距离均缩短(P.05);术后7 d,O组与C组比较,潜伏期和游泳距离延长程度缩小。

The results showed: taurine has no significant effects on the numbers of erection, mounting, intromission and ejaculation, the latent periods of erection and catching in young rats, but can significantly increase the numbers of erection, mounting and ejaculation, obviously decrease the latent periods of erection and catching in old rats.

结果证明:牛磺酸对青年大鼠勃起次数、勃起潜伏期、乘骑次数、插入次数、射精次数、捕捉潜伏期没有影响,但可显著提高老年大鼠勃起次数、乘骑次数、射精次数,明显缩短勃起潜伏期和捕捉潜伏期

Methods: the animal model was produced by means of putting special moulds on the male rats being bred in cages separately. Using CHAIHUSHUGAN POWDER as trial drug to smooth the circulation of liver-Qi, the targets such as oltaction-licking latency % intromission latency, intromission frequency, ejaculation latency,ejaculation frequency, post-ejaculation interval had been observed. Fluorospectrophotometry had been used to measure the content of 5-HT in respective specimen which had been produced by separating plasm, fluid of broken platelets from rats venous blood and homogenating the hypothalami.

通过带模具单笼饲养法造模,以柴胡疏肝散作为疏肝理气试验用药,观察大鼠的嗅舔潜伏期、插入潜伏期、插入次数、射精潜伏期、射精次数、射精后不应期;取大鼠静脉血和下丘脑,制备血浆、血小板破碎液和下丘脑匀浆,运用荧光分光光度法检测各标本5-HT的含量。

Results Wenshen Kechuan Tablets could significantly prolong the cough latent period and cough times within 3 min and increase phenol red secretion from trachea in cough model induced by ammonia water. Wenshen Kechuan Tablets could significantly prolong the asthma latent period and relieve spasm in guinea pigs with histamine-acetylcholine-induced asthma, prolong spasm latent period and reduce shock attack and lung overfall volume in guinea pigs with ovalbumin-induced asthma.

结果 温肾咳喘片可显著延长氨水致咳小鼠的引咳潜伏期、减少3 min内的咳嗽次数,增加小鼠气管段酚红排泌量,明显延长组胺-乙酰胆碱致敏豚鼠的引喘潜伏期、减少抽搐动物数,延长卵白蛋白致喘豚鼠抽搐潜伏期和减少跌倒休克豚鼠数,减少卵白蛋白致敏麻醉大鼠的肺溢流量。

In Wistar rats, latent period of a-wave in scotopic rod response after 1-week transplantation was shorten (P.05); and latent period of a-wave in scotopic rod response after 2-week transplantation was prolonged (P.05); while latent period of b-wave in scotopic maximum response after 1-week transplantation was shorten (P.05). In RCS rats, amplitude of a-wave in scotopic rod response and photopic response after 4-week transplantation was increased (PO.05); while latent period of a-wave in scotopic rod response after 4-week transplantation was shorten (PO.05).Conclusion 1. At the age of 3 months, photoreceptors of the RCS rat degenerated completely, which leaded to the reduction of amplitudes of a-wave and b-wave.

Wstar大鼠术后1周的暗适应视杆反应,a波潜伏期缩短o叼。05);术后2周的暗适应视杆反应,a波潜伏期延长o功刀5):术后1周的暗适应最大反应,b波潜伏期缩短o功刀5卜*CS大鼠术后4周的暗适应视杆反应和明适应反应,a波振幅增大o功刀匀;术后4周的暗适应视杆反应,a波潜伏期缩短o<0卜结论1、RCS大鼠在3月龄时感光细胞变性死亡,导致FERG的a、b波振幅明显降低;视网膜下腔仍存在感光细胞外节盘膜碎屑,外丛状层缺乏感光细胞的突触末端,同时Muler细胞出现反应性胶质纤维增生。

In subliminal affective priming task, there were no significant differences of correct rates and latencies between alexithymic and nonalexithymic,while on the both two SOA levels (200ms and 300ms) of supraliminal priming task, the mean response latencies of alexithymic were longer than those of nonalexithymic.(4) In both subliminal and supraliminal affective priming tasks, P2 and P3 were elicited by both alexithymic and nonalexithymic during performing the affective priming task.

情绪启动效应早期的ERPs特征表现为启动条件和非启动条件的P2潜伏期均显著短于控制条件的P2潜伏期,而P2波幅则显著大于控制条件的P2波幅,这种效应在顶区表现得尤其明显;情绪启动效应晚期的ERPs特征表现为启动条件P3潜伏期显著短于非启动条件的P3潜伏期,而P3波幅显著小于非启动条件和控制条件的P3波幅,这种差异也主要见于顶区。

kongming mice and Wistar rats were used to observe the effects of SGYY capsule on sexual desire,erection, ejaculation. and fatigue. The weight of prostate, seminal vesicle, testes, levators and thymus and serum testosterone level were also measured.

通过观察疏肝益阳胶囊对大、小鼠阴茎勃起潜伏期、扑捉潜伏期、射精潜伏期、扑捉次数、射精次数、前列腺、精囊、睾丸、提肛肌、胸腺的重量,血清睾酮水平以及游泳耐力和抗缺氧能力的影响。

Reveal the characteristics and regular pattern of its epidemic.①Investigated the epidemiological history of 448 clinical confirmed SARS cases, drawing the map of coming places of primary cases and whereabouts of the secondary cases, clarify the reasons of SARS inputting and spreading.②Exploring transmission relationship between cases by drawing the chain-map and learning the main transmission process.③Selecting the chain-cases with the exact onset and contact time to calculating the average incubation of same generation cases on different transmission chains and the average incubation of different generation cases on same transmission chain, Calculating the incubation median, the fifth percentile and the ninety-fifth percentile of the incubation of the observed cases.④Analyzing the timeliness of admission and the treating condition through the statistical calculation of the onset time, the admission time, the hospitalization time as well as the diagnostic time of the suspect and clinical confirmed cases.

调查全省448例SARS临床确诊病例的流行病学史,绘制全省输入SARS原代病例的主要来源以及引起传播后被感染者的去向图,阐明SARS病例的输入与扩散原因;②用传播链图分析传播关系,了解SARS的主要传播过程;③选择SARS原代病例与续发病例接触日期、发病日期明确而完整的传播链病例计算不同传播链同一代之间以及同一传播链不同代之间的平均潜伏期,并计算观察病例潜伏期的中位数以及第5、第95百分位数,确定SARS的最短潜伏期和最长潜伏期;④对患者发病、就诊、住院时间以及医院诊断为SARS可疑病例、临床确诊病例的时间进行统计,分析SARS就诊的及时性以及临床诊治情况;⑤计算不同接触方式、关系密切程度传播SARS的危险度,筛选形成传播的主要危险因素;⑥检测不同人群和同一人群不同时间的SARS血清抗体,了解抗体的阳转时间和持续时间。

"Because of the powerful genetic effects on incubation periods in laboratory animals, vCJD patients identified could represent a distinct genetic subpopulation with unusually short incubation periods for BSE prions, with vCJD so far occurring predominantly in those individuals with short incubation time alleles at these multiple genetic loci, in addition to having the homozygous PRNP genotype of codon 129 methionine," they write.

因为动物实验表现出基因对潜伏期的强力影响,鉴定vCJD病患表现出清楚的基因次族群和BSE传染性蛋白质的不寻常短潜伏期;vCJD病患目前显著地发生在短潜伏期对偶基因者,密码子129蛋氨酸的PRNP 基因是同型合子。

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