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In 1892, D.Ivanowsky of Russia had first shown that the causal agent of tobacco mosaic disease was filterable, but Beijerinck went much further and provided strong evidence that although the causal agent was filterable, it had amny of the properties of a living organism.

在 1892年,俄国的 D.Ivanowsky 首先证明了烟草花叶病的病原体是具有可滤过性。但是荷兰的Beijerinck研究得更深入,不仅提供了充分的证据证明尽管病原体是可滤过的,但是它却具有了生命体的所有特征。

Objective: To investigate the efficacy and feasibility of mitomycin C drug delivery system as a new glaucoma anti-scarring agent by observing its effects on a rabbit model of glaucoma filtration surgery and side effects on eyelid,conjunctiva,cornea,and anterior champer of rabbit eye.

目的:研究丝裂霉素C缓释系统(mitomycin C drug delivery system,MMC DDS)对兔眼滤过性手术后抗瘢痕形成的疗效及对兔眼局部组织的毒副作用,探讨其作为青光眼滤过性手术后抗瘢痕形成的辅助用药的可行性和有效性。

BACKGROUND: Fibration and scar formation are major factors for surgical failure following glaucoma filtration. Although there are so many drugs and methods to inhibit scar formation, they are not ideal.

背景:青光眼滤过后,滤过道的纤维化与瘢痕组织形成,是手术失败的主要原因,虽然抑制青光眼滤过术后瘢痕形成的药物和给药方法很多,但多不理想。

Methods 36 cases of UE with sustaining hemodialysis between March 2008 and June 2009 was retrospectively analyzed,20 of which received hemoperfusion online continuous venovenous hemofiltrationand 16 only underwent continuous venovenous hemofiltration.Heartrates,mean arterypressure,APACHEII score,kalium ion,hydrocarbonic radical,blood urea nitrogenand serum creawere detected before and aftertherapy.

回顾性分析我院2008年3月至2009年6月维持性透析合并尿毒症脑病的患者36例,其中20例行血液灌流串联连续性静脉-静脉血液滤过,16例行单纯连续性静脉-静脉血液滤过,比较两组治疗前后心率、平均动脉压、APACHEⅡ评分、钾离子、碳酸氢根、尿素氮、血肌酐变化以及神经精神症状缓解情况和到达缓解所需时间。

Morphology of FBCF tends to have more diffused and posterior bleb, while bleb of LBCF tends to have microcyst and have a ring of sear tissure.

滤过泡形态LBCF主要以边界清晰的微小囊泡型为主,上方一般有明显界限;FBCF主要以弥散型为主,滤过向后方和鼻侧或颞侧弥散,上方一般无明显界限。

Of the strength of filtration and reabsorption.

滤过压的大小,即滤过的力量和重吸收的力量之差。

Methods:Phacoemulsification and implantation with foldable and rigid intraocular lens were performed on 41 eyes with a preexisted filtering bleb,and a clear corneal or scleral tunnel incision was selected.

32例 (4 1只眼)抗青光眼滤过术后的白内障患者,采用上方透明角膜隧道切口和避开滤过泡的巩膜隧道切口行白内障超声乳化吸除,植入折叠式人工晶状体 2 4只眼,硬性人工晶状体 17只眼。

The filtering blebs possessing function presented in 128 eyes (84.1%).

滤过泡呈扁平状的功能性滤过泡者138眼(84.1%)。

AbstractAIM: To investigate the efficacy of needle revision with mitomycin C(MMC on the dysfunctional filtration blebs after trabeculectomies.

小梁切除术是目前抗青光眼手术的主要方式之一[1,2],滤过泡是判断术后滤过效果的一个明显特征。

METHODS: Thirtyfour patients (35 eyes) underwent the needle revision of the dysfunctional blebs with MMC at clinic visits in 322 weeks after trabeculectomy and observed blebs reformation and the descent of intraocular pressure followed up for more than 6 months.

滤过泡的瘢痕化、包裹均可导致手术失败,眼压再次上升进而对视神经造成不可逆的损害。其主要原因是巩膜瓣、Tenon's囊和结膜之间的粘连愈合而不是滤过口的阻塞[3]。

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