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Positive immunostain Fas and FasL was mainly located in the cytoplasm and membrane of syncy-tiotrophoblast and cytotrophoblast.

Fas及FasL在重度子痫前期组胎盘绒毛滋养细胞的表达与新生儿出生体重和胎盘重量均有明显相关性。

Results l.Serum concentrations of VCAM-1 in PIH (93.39 + 57.3)ug/ml were higher than that in normal pregnant group. Serum concentrations of VCAM-1 in moderate(97.89 + 34.07)ug/ml and severe PIH(132.24 + 60.97)ug/ml were significantly higher than that in normal group.(P.05, P.01). There was no difference between serum levels of VCAM-1 mild PIH and normal pregnant group. 2.Serum levels of IL-6 in PIH group(102.17 ?48. 31)pg/ml were significantly higher than that in normal group(49.16 + 12.9)pg/ml.Serum levels of IL-6 in moderate(95.79+31.19)pg/ml and severe PIH( 127.27+11.3 8)pg,ml were significantly higher than that in normal group. There was no difference between serum levels of PIH in mild PIH (52.13 + 12.90)pg/ml and normal pregnant group. 3. In PIH group, serum concentrations of VCAM-1 correlate with the levels of IL-6,r=0.63. 4.The expression of VCAM-1 in cytotrophoblast of spiral arteries in normal pregnant group(100%) were significantly higher than that in PIH group.Theexpression of VCAM-1 in moderate PIH(37.50%) and sever PIH were lower than that in normal group.There was no difference between the mild PIH and normal group.Conclusions The increased levels of serum of VCAM-1 may participate in the process of vascular endothelium damages in PIH.

结果 1、妊高征组血清VCAM-1浓度为(93.39±57.3)μg/ml明显高于正常妊娠组(44.87±15.60)μg/ml,差别有显著性(P<0.05);中、重度妊高征组VCAM-1浓度分别为(97.89±34.07)μg/ml和(132.24±60.97)μg/ml,与正常妊娠组比较,差异有显著性(p<0.05)和非常显著性(P<0.01);轻度妊高征组VCAH-1为(48.46±15.60)μg/ml与正常妊娠组比较,差异无显著性(P>0.05)。2、妊高征组血清IL-6含量为(102.17±48.31)pg/ml,明显高于正常妊娠组(49.16+12.9)pg/ml,差异有非常显著性(P<0.01);中、重度妊高征组IL-6含量分别(95.79±31.19)pg/ml和(127.27±11.38)pg/ml,与正常妊娠组比较,差异有显著性(P<0.05)和非常显著性(P<0.01);轻度妊高征组IL-6含量为(52.13±12.90)pg/ml与正常妊娠组比较,差异无显著性(P>0.05)。3、VCAM-1与IL-6水平呈明显正相关,r=0.63(P<0.01)。4、子宫胎盘床螺旋动脉滋养细胞VCAM-1表达,正常妊娠组都存在阳性表达(阳性表达率100%),妊高征组有10例阳性表达阳性表达率为叩们,差别有非常显著性河<0.01L 中、重度妊高征组阳性表达率分别为37、50%和0,与正常妊娠组比较,差别有显著性河<0.05)和非常显著性汀<0.01太轻度妊高征组阳性表达率为83.33凡与正常妊娠组差别无显著性问>0.05)。

In HM, IM and CC, the normal expression rates of Ecad were 53.3%, 31.25% and 16.67%, respectively; the strong expression rates of LN were 80%, 56.25% and 50%, respectively.

目的 探讨上皮型钙粘附蛋白和层粘连蛋白在妊娠滋养细胞疾病中的表达及意义。

Results The normal expression rates of Ecad and the strong expression rates of LN in GTD were 37.8%(28/74) and 64.86%(48/74), respectively, and were significantly lower than those in normal villus tissue.

目的 探讨上皮型钙粘附蛋白和层粘连蛋白在妊娠滋养细胞疾病中的表达及意义。

Objective To investigate the expression of human telomerase reverse transcriptase in gestational trophoblastic diseases and its clinical significance.

目的 探讨人端粒酶逆转录酶在妊娠滋养细胞疾病中的表达及其临床意义。

Objective To investigate the features of p53 in gestational trophoblastic tumor.

目的 研究妊娠滋养细胞肿瘤中p53的表达及意义。

Objective To investigate the expression of human telomerase reverse transcriptasein gestational tro-phoblastic diseases and its clinical significance.

目的 探讨人端粒酶逆转录酶在妊娠滋养细胞疾病中的表达及其临床意义。

The positivity rate of MMP-2 and TIMP-2 in gestational trophoblastic tumor group was higher than that of the normal chorion of early gestation group and hydatiform mole group (P.05 and P.001, respectively).

妊娠滋养细胞肿瘤组与正常绒毛、葡萄胎组相比,MMP-2、TIMP-2的表达均有显著性差异(P.01, P.00l)。

The imbalance of their expressions may be one of the causes of oligohydramnios.

Caspase3与Bcl-2在胎盘滋养细胞中的表达失衡可能是羊水过少发生的原因之一。

The expressions of caspase3 and Bcl-2 in placenta may play important roles in oligohydramnios.

胎盘滋养细胞Caspase3高表达、Bcl-2低表达可能与羊水过少的发生有关。

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