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Shortly after implantation the blastocyst wall, the trophoblast, consists of two layers of cells.

植入之后不久,胚囊的壁,即滋养细胞含有两层细胞。

The difference of survivin expression intensity was statistically significant (P.05). Conclusion: A suitable-expression of survivin in normal early gestation villi may be crucial for embryo karyokinesis and cell proliferation. An over-expression of survivin in GTDs may be an important role in their oncogenesis.

适度survivin是正确完成胚胎细胞有丝分裂和细胞增殖的必要条件,因survivin的过表达引起的细胞凋亡阻滞在妊娠滋养细胞疾病的发生发展过程中可能起重要作用。

The components of milkvitch-red sage compound restrain the placental immune pathologic damnification and the languishment of nutrient cells of NO Synthesis blocking rats, which is probably due to the accommodation of bcl-2/Bax expression.

黄芪、丹参复方成分阻抑一氧化氮合成阻滞大鼠胎盘免疫病理损伤,阻抑胎盘滋养细胞凋亡,并可能是通过调节bcl-2/Bax表达变化而影响细胞凋亡。

Objective: To investigate the effects of LPS on the invasion oftrophoblasts and the role of apoptosis in the above procession.

目的:探讨脂多糖对细胞滋养细胞侵入能力的影响及细胞凋亡在此过程中的作用。

It is primarily used to treat cancer, and it will have a hetter therapeutic effect when treating trophohlastic tumor.

妊娠早期滋养细胞增生活跃,MTX用于滋养细胞肿瘤的治疗,疗效佳。

The expression of subunits α5,β1,β3 was detected in normal morulas and increased in blastocysts. The expression of subunit α1 was not detected in morulas or blastocysts, but detected only in outgrowing trophocytes. 3. Expression of integrin β3 in irradiated group embryos was weaker than that of normal group. There was no expression of integrin α1 both in morulas and blastocysts in irradiated group and no difference in the expression of subunits α5 and β1 between these two groups.

结果:1、超声波照射组胚胎贴附率、滋养细胞外延生长率均显著低于正常胚胎。2、正常胚胎桑椹胚期即有α5、β1、β3整合素表达,而无α1表达;囊胚期α5、β1、β3表达增强,仍无α1表达;α1只出现在外延生长的滋养细胞。3、超声波照射组胚胎β3整合素的表达明显弱于正常组,且未见α1表达;而α5、β1的表达两组间无差异。

The coincident decreased expression of EGFR and NM23 may play an important role in the development of trophoblastic tumors.

EGFR与NM23在恶性滋养细胞肿瘤中两者一致性减低,提示这种减低可能在滋养细胞肿瘤的发生及恶性转化中有协同作用。

The activation of endothelial cell caused by TNF-α has detrimental effects on the vasculature. TNF-α can induce the increased apoptosis of gravid trophocyte. TNF-α has been showing up-regulate the vasoconstriction factors such as endothelin and down-regulate the vascular relaxing factors such as NO on the contrary.

肿瘤坏死因子α作为炎性分子,激活血管内皮细胞、间接影响血管舒缩功能,通过各种机制诱导胎盘滋养细胞凋亡增加,增加血管收缩因子并减少血管舒张因子的生成和释放,影响与脂类代谢相关的细胞因子。

Measure normal early pregnancy choria tissue and JAR cell by RT-PCR, LH/hCG receptor mRNA expression on both pregnancy choria tissue and JAR cell which is consistent with that be measured in ovarian granulosa cells, indicate that JAR cell and normal choria trophocyte presence LH/hCG receptor, hCG is one of the autocrine hormone.

二、用RT-PCR法可测到正常妊娠早孕绒毛组织、JAR细胞的LH/hCG受体mRNA表达,与正常卵巢颗粒细胞所表达的LH/hCG受体mRNA一致,提示JAR细胞与正常绒毛滋养细胞存在LH/hCG受体,hCG为其自分泌激素之一。

Results :The indensities of both MMP-2 and MMP-9 immunostaining in preeclampsia placentae were sig...

MMP-2和-9是妊娠期滋养细胞侵袭的关键酶,MMP-2和-9的表达降低,导致滋养细胞侵袭能力的下降,可能在子痫前期的发病机制中起着重要的作用。

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