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Urumqi 830011, ChinaAbstract: Objective: To explore the use of EMA/CO project in gestational trophoblastic tumor.

目的:探讨EMA/CO方案在妊娠滋养细胞肿瘤中的应用价值。

Methods: Paraffin section HE stain, light microscopy calculate the area of trophocyte area rate.

石腊切片,伊红、苏木素染色,光镜分析,计算滋养细胞面积比率。

There was no adverse effect. It showed that Bushen Yangtai Pill could increase the cure rate of development and functional defect of trophocyte effectively. The mechanism of action may relate with the improvement of womb and ovarian, the promotion of growth and development of the blood current of womb and ovarian, and precipitate of secretion of yellow body of ovary and endometrial gland.

说明补肾养胎丸可明显提高滋养细胞发育和功能不全的治愈率,作用机理可能与改善子宫与卵巢的血流,促进卵巢及子宫的生长发育,促使卵巢黄体及子宫内膜腺体的分泌有关。

From this study, both low hCG and high hCG are adversity to pregnancy, hCG level reflect the growth and function situation of trophocyte which is the main component of placenta, whereas, the level of steroid hormone which close to hCG directly influence whether pregnancy will maintain, but in some cases being short of oxygen in uterine placenta local, usually display hCG level higher than normal pregnancy.

在正常妊娠时hCG过低往往预示着流产的可能,从本研究结果看,可能不仅仅是hCG水平过低对妊娠不利,hCG水平很高对妊娠也不利。hCG水平的高低反映了作为胎盘主要组份的滋养细胞的生长情况与功能,而与hCG水平高低密切相关的类固醇激素的高低直接影响了妊娠能否持续下去。

That because dyoxygen induced trophocyte proliferation and hCG secretion, at that moment, hPL level is not high, which is consistent with hPL level in placenta dysfunction, What this study show that hCG increase being not promote hPL secretion significantly may explain the phenomenon.

而在一些妊娠晚期子宫胎盘局部缺氧的病例,往往表现为hCG水平高于正常相同孕周妊娠者,这是因为缺氧诱发了滋养细胞的增生,hCG大量分泌,但此时hPL水平不高,是与胎盘功能不良时hPL水平往往不高相一致,本研究结果显示的hCG增高并不明显促进hPL的分泌可能可以解释这一现象。

Objective Measure contents of HCG,HCGβ with RIA to diagnose early pregnancy or unpregnant's pathology phenomenon.

人绒毛膜促性腺素是一分子量为35000的糖蛋白激素,具有4级结构,由2个不相等的亚级组成,即人和β亚基,HCG主要由合体滋养细胞分泌。

Aim: To investigate the effect of mifepristone on expression of Ang-1 in human villous trophoblasts during the early pregnancy and its role in regulating villous angiogenesis.

目的:通过观察米非司酮对人早孕绒毛滋养细胞血管生成素-1(Ang-1)表达及绒毛间质血管生成的影响,探讨Ang-1在绒毛间质血管生成的作用。

Methods: Immunohistochemicl method was used to detect the expression of Ki -67 in human villi and GTD.

采用免疫组织化学的方法,观察正常早期妊娠绒毛和妊娠滋养细胞疾病组织中Ki-67的表达。

The expression of VCAM-1 in chronics micrangium endothelial cell of utero-placental bed in SP groups was significantly higher than that is in MP groups (P.05, P.05) and normal pregnant groups (P.01, P.01), there were also significant differences (P.05, P.05) between MP andnormal pregnant groups.

2子痫前期重度组胎盘绒毛合体滋养细胞上VCAM-1的表达阳性率和表达强度明显低于对照组(P.01,P.01)和子痫前期轻度组(P.05,P.01),子痫前期轻度组与对照组比较亦有统计学意义(P.05,P.05)。

Results Only 626 Cases (51.56%) were found uneven intrauterine echogram by B-type ultrasound,but 1194 cases(98.35%) were detected image of peritrophoblastic flow by colorful Doppler ultrasound.

结果病理诊断宫腔残留1214例,二维超声以宫腔不均质回声团为诊断标准,符合率达51.57%(626/1214),彩色多普勒以探测到滋养细胞周围性血流为诊断标准,符合率达98.35%(1194/1214)。

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