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RESULTS The gallstone formation rate was 100%when an animals were fed on high cholesterol diet, but in antilithic group, the rate decreased to 5.3%when fed on HCD with ACRC.

结果 喂养高胆固醇饮食的致石组动物胆结石的发生率为100%,而加用利胆溶石胶囊的防石组,成石率降至5.3%。

Objective To explore the clinical value of endoscopy combined with local infusion of dissolving agents for treatment of cholelithiasis.

目的 探讨内镜联合药物灌注溶石治疗复杂胆管结石的临床应用价值,提高对巨大胆管结石的治愈率。

Administration by gavage a mixture of melamine and cyanuric acid may produce insoluble melamine cyanurate crystals in kidney, which will block the tubules and cause renal damage and even acute renal failure. The melamine cyanurate crystals may form urinary calculi with uric acid and other components.

三聚氰胺和三聚氰酸联合灌胃大鼠的肾脏内会形成一种不溶于水的三聚氰胺氰尿酸盐晶体,堵塞肾小管造成肾脏损害甚至急性肾功能衰竭,并可能与尿酸等成分一起诱发泌尿系结石。

The No.1 litholytic compounds is a new and safe cholesterol gallstone contact solvent with efficient and lower toxicity for treatment of cholecystolsithiasis.

复方溶石剂1号是一种新型、安全、高效、低毒的胆固醇结石直接溶石剂。

Results the No.1 litholytic compounds dissolved the cholesterol gallstone(500mg)in no more than 25 min (21.6±4.9 min),less influence to blood biochemical,no harm to the other organs of rabbits except gallbadder.

结果 复方溶石剂1号对500mg的胆固醇结石溶解时间少于25min(21±4.9min),对动物的血液生化指标影响不大,除胆囊外未对全身其他脏器造成损害。

To improve the effect of CDCA on dissolving cholesterol gallstone, the water-soluble copolymers as polycarboxylic acid of comb-like copolymers and C_(60)-PCC were synthesized, which being used for modification of CDCA and strengthening effects of CDCA on dissolving the cholesterol gallstones by their entropy-repelled properties of comb-shaped side chains in buffers of phosphate and in model bile.The design theory of polymer was mainly employed to synthesis the conjugate of PCC-CDCA and C_(60)-PCC-CDCA by C_(60), polyoxyalkylene allylalkyldiether and maleic anhydride, which were copolymerized with AIBN as initiator, and then PCC or C_(60)-PCC were reacted with CDCA. The structures of the copolymers and the conjugates of PCC-CDCA and C_(60)-PCC-CDCA were confirmed with IR, TLC and TEM. The dissolving effects and the dissolution kinetics mechanism of cholesterol gallstone was inverstigated in PBS and in model bile of different cholesterol saturated index at pH7.4, including PCC-CDCA or C_(60)-PCC-CDCA.

利用高分子设计理论,以烯丙基聚氧乙烯基醚、顺丁烯二酸酐、C_(60)和CDCA为原料,以偶氮二异丁腈为引发剂,合成具有梳状侧链结构的梳状共聚物-CDCA结合物和C_(60)-梳状共聚物-CDCA结合物,以IR、TLC和TEM法表征共聚物的结构,并在pH7.4的PBS液和不同胆固醇饱和指数的模拟胆汁中进行溶石效果的研究,探讨在PBS液和不同CSI的模拟胆汁中结合物溶解胆固醇结石的效果和溶解动力学机制。

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