溶剂化物

The preparing process is described as follows:(1) the raw materials are dispersed in the solvent;(2) the solution is arranged between two electrodes;(3) alternating current with a voltage of 5 V-100V and a frequency of 10Hz-1000Hz is applied to both ends of the electrodes for 5minutes to one hour;(4) the product obtained after being washed with deionized water and pump filtrated or after centrifugal treatment is dried by being heated to 40 centigrade to 100 centigrade to get the nanometer grain, wherein the raw materials in the first step are micrometer materials or nanometer materials such as sulphide, selenide, telluride and oxide; without special requirement on shape or appearance, the materials can be in the shape of a rod, a fork, a star, a block or a sphere; the solvent in the first step can be water, ethanol, acetone, benzene or tetra chloromethane.

步骤为：1将原料分散于溶剂中；2使制成的溶液处于两电极之间；3在电极两端的加交流电，电压为5V-100V，频率为10Hz-1000Hz，时间为5min-1h；将产物用去离子水洗涤、抽滤，或进行离心处理后；4将所得到产物加热到40～100℃进行干燥，得到纳米颗粒。步骤1中原料为硫化物、硒化物、碲化物、氧化物等微米或纳米材料，其形貌不限，可以为棒状、枝状、星状、块状、球形等多种形状。步骤1中的溶剂可以为水、乙醇、丙酮、苯或四氯化碳。

Experimental process: jing and 3- methyl -2- methyl ethyl ketonesynthesizes by the benzene zong; Again the glacial acetic acidcatalysis produces 2, 3, 3 - trimethyl - 3H - yinduo; Again has thealkylate response production yinduo iodide after the methyl iodide;The iodide takes off molecular HI under NaOH to become freejier thealkali; Adds 5 - nitryls salicylic aldehydes in the ethyl alcohol forthe solvent under if to respond finally produces 6 '- the nitryl yinduolin spiral benzene and pinan; Through the infrared spectrum andthe ultimate analysis irrevocably proved its structure, and studiedthe annulus with to open the annulus the light to send changes colorthe performance, explained in different solvent medium ultravioletabsorption spectrometry solvent effect, and the comparisondiscoloration the response speed number difference, finally mixed itadds to the methyl methacrylate, the peroxidation benzoin formyl in the plexiglass, tested 6 '- the nitryl yinduolin spiralbenzene and pinan in the glass fatigue resistance, thethermostability.

实验过程：由苯肼和3-甲基-2-丁酮合成腙；再冰醋酸催化生成2 ，3 ，3—三甲基—3H—吲哚；再经过碘甲烷发生烷基化反应生成吲哚碘化物；碘化物在NaOH下脱去一分子HI成为费歇尔碱；在乙醇为溶剂下加5－硝基水杨醛与其反应最后生成6'—硝基吲哚啉螺苯并吡喃；通过红外光谱和元素分析确证其结构，并研究了环体与开环体的光致变色性能，解释了在不同溶剂介质中紫外吸收光谱的溶剂效应，并比较褪色反应速率数的差异，最后将其掺加到甲基丙烯酸甲酯，过氧化二苯甲酰有机玻璃中，测试6'—硝基吲哚啉螺苯并吡喃在玻璃中的抗疲劳性、热稳定性。

Compared to solvates and salts which are limited to small numbers of nontoxic solvents and ionizable drugs, cocrystals represent a very promising designable solid form of active pharmaceutical ingredients, due to their extensive species and wide application scope.

常见的固体形态如溶剂化物、盐，因为种类少或适用的药物少而在应用上受到一定的限制。所以种类多、适用范围广的共晶作为可设计的药物固体形态近年来逐渐受到关注。

Disclosed are compounds of Formula or pharmaceutically acceptable salts or solvates thereof.

本发明公开了式化合物或其药物学上可接受的盐或溶剂化物。

Transition metal borides and inorganic boron-containing compounds, such as TiB〓, BN, B〓C and BP, are one of the most important groups for application in high-temperature performance, electronics and catalysts. Traditionally, they were prepared by high-temperature reactions; however, the products were beyond nanometer scale.

中文题名溶剂热合成硼化物及非金属含硼化合物纳米材料副题名外文题名论文作者谷云乐导师钱逸泰学科专业无机化学研究领域\研究方向学位级别博士学位授予单位中国科学技术大学学位授予日期2003 论文页码总数70页关键词纳米材料硼化物溶剂热合成馆藏号BSLW /2003 /O613 /6 硼化物、非金属含硼化合物功能材料（如硼化钛、氮化硼、碳化硼和磷化硼等）通常具有高硬度、高熔点、机械强度大、高温化学稳定性好等一系列优良性能，有些还具有奇异的光、电、磁、热学性能和催化活性，是一类最富潜力的非氧化物高温结构材料、电子材料和催化材料。

It should be emphasized that the manufacturing process is responsible for producing particular polymorphs or solvates; the control methods merely determine the outcome.

应该强调的是，生产工艺对生产特定的同质多形异构体或溶剂化物是直接相关的。控制方法只是决定结果。

For case, suitability means that the procedure can detect and quantitate polymorphs and/or solvates in admixtures of such forms, or measure particle size.

对于情况，适用性是指该程序可以检测和估计混合物中的多晶型物和溶剂化物，或者它可以测量颗粒尺寸。

Conditions used in manufacture and/or storage of the drug substance may result in the isolation or formation of a solvated or hydrated drug substance.

制造和储存原料药的条件可能会导致离析或形成溶剂化物或水化的原料药。

The millimetersized tubular crystal selenium was first prepared. By studying the process of treating selenium in ethylenediamine, we proposed the mechanism of the preparation of selenides under solvothermal condition. The selenides came into being from the reaction of metal ions with Se〓, which was obtained by the amine attacking selenium. Moreover, a new precursor to prepare nanocrystalline selenides at room temperature was obtained. From this precursor, we have prepared nanocrystalline silver selenides, copper selenides, lead selenides and cadmium selenides nanorods.

首次报道了采用溶剂热处理的方法制备出厘米尺度的管状结构硒晶体；通过对硒粉在乙二胺中的溶剂热研究，初步探讨了以单质硒为硒源的溶剂热合成硒化物的反应机理应是硒受胺类的亲核进攻变成Se〓而进一步形成相应的硒化物；获得了合成硒化物纳米晶的前驱物，并在室温条件下合成了硒化银、硒化铜、硒化铅纳米晶和硒化镉纳米棒等。

It should be emphasized that the manufacturing process is responsible for producing particular polymorphs or solates; the control methods merely determine the outcome.

应该强调的是，生产工艺对生产特定的同质多形异构体或溶剂化物是直接相关的。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。