溴酮

Secondly, the reaction of crotyl bromide and carbonyl compounds promoted by dysprosium were studied. The γ-adduct of crotyl was mainly obtained in the reaction of ketone and ester. While the α-and γ-adduct mixture were obtained in the reaction of aldehyde.

其次，还研究了镝促进下巴豆基溴与羰基化合物的反应，酮和酯主要得到巴豆基γ-位进攻的产物，而醛则得到α与γ位进攻的混合产物。

In the second part of the thesis, we discussed a L-proline-catalyzed direct Aldol reaction between L-amino acid-derived N,N-dibenzyl -amino aldehydes 15 and acetone, cyclopentanone or hydroxyacetone, which afforded (-amino--hydroxy- or (-amino-,(-dihydroxy-ketones in good to excellent yields (up to 94%) and diastereoseletivities (up to 94.9%).

发现许多情况下，反应的产率和de值超过90%。接着，在碱性条件下，我们将L-亮氨酸衍生的N，N-二苄基--氨基醛15g与羟基丙酮反应得到的主要产物(，-二羟基-γ-氨基酮171d与次溴酸钠反应，得到了具有抗肿瘤活性的天然产物PM-94128的氨基酸片断184。

A sample-pretreated method of ether-extraction-precolumn-derivation was established, and the chromatographic conditions, which was used for determinating the derivant of extracted UDCA, were decided to be Hypersil C_(18) column(250×4.6mm, 10μm), acetonitrile-methol-0.005mol·L~(-1) phosphoric buffer-triethylamine(50:27:42:0.25, adjusted to pH3.0±0.1 by phosphoric acid) as mobile phase with detective UV wavelength at 247nm and column temperature at 35℃.

建立了乙醚提取-柱前衍生化血浆样品预处理方法，采用Hypersil C_(18)柱(250×4.6mm，10μm)，乙腈-甲醇-0.005mol·L~(-1)NaH_2PO_4缓冲液-三乙胺(50：27：42：0.25，磷酸调节pH3.0±0.1)为流动相的HPLC法，以溴苯乙酮为衍生化试剂，在247nm处测定家兔血浆中熊去氧胆酸衍生化产物。

Results The synthesis condition was improved. The method of methane sulfonic acid/DL-methionine was found an ideal substitute of BBr3 for less cost. While using hydrobromic acid, the O-demethylation and hydrolyzation could be combined in one stage.

结果 优化了纳洛酮的合成工艺，甲磺酸／DL-甲硫氨酸法试剂价格低廉，可降低生产成本；而氢溴酸法不但试剂价格更低，还可将去氧甲基化和水解合并为一步反应，使新工艺的总收率提高到59.90%，产品质量符合中国药典。

The intramolecular Reformatsky-type reaction of benzyl bromide and keto group is the key step.

其中关键步骤是苄溴与酮基的分子内Reformatsky型反应。

According to the requirements from different clients, we have adopted CP2000,BP98,USP standards to produce Galanthamine Hydrobromide .We also have other products, such as Dihydrogalanthamine hydrobromide （98%HPLC）, Lycorine（98%HPLC）and so on.

公司其它产品有氢溴酸二氢加兰他敏(98% HPLC)、石蒜碱(98% HPLC)，虎杖提取物、灵芝提取物、枳实提取物、黑升麻提取物、绿茶提取物、枳实黄酮等。

Silver nanoparticles with average particle size ranging from 2 to 131nm were manipulatively synthesized starting from silver nitrate using 10 kinds of different functional group-containing organic modifiers, such as polyvinylpyrrolidone, tween-80, sodium dodecyl sulfate, sodium polyacrylate, polyethylene glycol, D-sorbitol, sodium dodecyl sulfonate, sodium dodecylbenzene sulfonate, polyvinyl alcohol, cetyltrimethylammonium bromide, at room temperature.

摘 要：选择10种含有不同官能团的有机物为表面修饰剂，如聚乙烯吡咯烷酮、吐温-80、十二烷基硫酸钠、聚丙烯酸钠、聚乙二醇、山梨醇、十二烷基磺酸钠、聚乙烯醇、十二烷基苯磺酸钠和十六烷基三甲基溴化铵等，在室温下进行了平均粒径在2～131nm范围内纳米银颗粒的控制合成研究。

That 1,4-addition reactions of Grignard agent made from 1-bromo-3-triphenylmethoxyl-1-octene and organozinc agent made from 1-iodo-3-trimethysiloxy-1-octene with 2-(6-methoxylcarbonylhexyl)-4-(2- tetrahydro-pyranyloxy)-2-cyclopentenone both gave prostaglandin 〓 methyl ester statethat prostaglandin E compounds can be prepared by 1,4-addition reaction oforganozinc agent.

最后，研究了溴化-3-三苯甲氧基-1-辛烯基镁和碘化-3-三甲硅氧基-1-辛烯基锌与2-(6-甲氧羰己基)-4-(2-四氢吡喃氧基)-2-环戊烯酮通过1，4-加成反应合成〓甲酯的方法，结果表明，用有机锌试剂通过1，4-加成反应来合成PGE类化合物是可行的。

None of them have been reported before. Some efforts were also made to find cupric ion as the right catayzer which could promote the cyclization of phenylhydrazine and a-bromoacetophenone efficiently.

为了扩展这一新的合成方法，我们用苯肼替代甲肼，发现在合适的催化剂存在下，苯肼也能够与α-溴代苯乙酮发生类似的环合反应，得到2，4-二苯基-1，2，3-三氮唑。

While in phenylhydrazine case, the intermediate phenylhydrazone was not active enough for the reaction of intermolecular condensation, unless in the presence of oxidizer, such as cupric chloride.

苯腙可以通过苯肼和α-溴代苯乙酮在没有催化剂存在下反应得到。

And discuss some key point of integrated management system design, include hazard identification and risk assessment and risk control in the occupational health and safety management, the measure of satisfaction target of customer, the flawlessness of law system, the integration of the integrated management system and enterprise standardization system, unify lead institution and work orgnization, integreted internal audit and integrated management review.

同时，论述了一体化管理体系构建中的几个主要问题，包括职业健康安全管理中的危险源辨识、风险评价和风险控制、顾客满意度的科学监测、法律、法规体系的完善、一体化管理体系与企业标准化体系的有机结合、统一的领导机构和工作机构、一体化的内部审核和管理评审。

Deepwater Taranaki is investigated for its petroleum potential, using all available seismic data tied to shallow-water wells.

运用与浅水井相关的现有全部震波探测数据考察了深海区塔拉纳基盆地的油藏前景。