淋巴结

The major clinical manifestation was lymph node enlargement found in all patients. Skin involvement and osteolysis were not frequent. The characteristic finding was leukemic cells with highly indented or lobulated flower-like nuclei in peripheral blood and bone marrow. ATL cells were CD2,CD3,CD4,CD25 positive and CD8 negative. No specific chromosome abnormality or HLA type was found. Seven of 8 patients examined had HTLV-Ⅰ antibody. The HTLV-Ⅰ provirus genome sequence integrated into host cell DNA was amplified by PCR and confirmed by liquid hybridization. All of these results showed that HTLV-Ⅰ was also the etiological agent of ATL in China. One of the 9 cases of ATL was classified as lymphoma type, one as chronic-type, and the rest as acute type.

结果和结论确诊9例ATL，其临床特征主要为淋巴结肿大，皮损及溶骨改变少见，外周血及骨髓出现典型的花瓣状核淋巴细胞，胞体大，核畸形，免疫表型为CD-1、CD+2、CD3+、CD4+、CD-8，还表达CD25等激活标记，染色体核型及HLA分型未发现有规律性的变化。8例ATL中有7例血清HTLV-Ⅰ抗体阳性，应用PCR及液相杂交法可检出整合到宿主细胞DNA中的HTLV-Ⅰ病毒序列，表明在我国HTLV-Ⅰ也是ATL的病因。9例中1例为淋巴瘤型，1例为慢性型，7例为急性型ATL，治疗效果及预后均不良。

Results The incidence of postcoital vaginal bleeding is lower in postmemoposal wemen than premenopausal wemen, the stages ,the incidences of pelvic lymph nodes metastasis, the results of the Pap smear cytology tests and HPV tests are not significantly different in two groups.

结果：绝经组与未绝经组比较，绝经组阴道接触性出血较未绝经组发生率低（P〈0.01），两组临床分期、淋巴结转移率、宫颈涂片细胞学检查阳性率及HPV检测阳性率无显著差异（P〉0.05），绝经组官颈腺癌发生率占5.2％，未绝经组占28.8％（65／226），两组中腺癌发生率差异显著（P〈0.01）。

Results: the incidence of postcoital vaginal bleeding was lower in postcoital wemen than that in remenopausal wemen, the stages, the incidences of pelvic lymph nodes metastasis, the results of the pap smear cytology tests and hpv tests were not significantly different in two groups. the incidence of cervical adeocarcinomai was lower in postmenopausal wemen than that in prmenoposal wemen. conclusion: the cervical cancer screening is necessary in postmenopausal wemen and they are helpful for preventing the development of cervical cancer.

结果 绝经组与未绝经组比较，绝经组阴道接触性出血较未绝经组发生率低（p＜0.01），两组临床分期、淋巴结转移率、宫颈涂片及细胞学检查阳性率差异无统计学意义（p＞0.05），绝经组宫颈腺癌发生率占4.2％，未绝经组占28.8%，两组中腺癌发生率差异有统计学意义（p＜0.01 结论绝经后妇女宫颈癌发病期别通常较晚，绝经后宫颈病变筛查是必要的，定期妇科检查、宫颈涂片细胞学检查可帮助绝经后妇女预防宫颈癌。

Statisticalanalysis showed that the point mutation of ras oncogenes play an important role in theprognosis of the patients...

点突变的发生与患者的预后、淋巴结转移及临床分期有关。

Patients developed head cervical lymph node swelling. The lymph node biopsy revealed a background of reactive lymphadenopathy and necrosis in some cases and apoptosis, nuclear debris in all cases, loss of lymph node structure, proliferation of lymphocytes and various types histiocytes with phagocytosis, no infiltration of neutrophils. Three histological types: proliferative, necrotizing and xanthomatous were classified.

形态特征为在活跃的反应性增生淋巴结病变的背景下，出现不同程度的凝固性坏死，淋巴细胞凋亡及核碎片几乎见于所有病例，伴有多种形态的组织细胞增生，吞噬现象明显，无中性杜白细胞浸润，组织学上可分为3型：增生型，坏死型及黄色瘤样型。

Objective The aim of this study was to investigate the expression of NF-κB and the re-expression of α-and β-catenin in cancer cells of metastatic lymph nodes in advanced gastric carcinoma.

目的 探讨进展期胃癌核因子κB(nuclear factor kappa B， NF-κB)蛋白的表达与α-catenin及β-catenin在转移淋巴结内癌细胞中的再表达情况及其与临床病理因素的关系。

Objective The aim of this study was to investigate the expression of nuclear factor-kappa B in the primary cancer cells and the re-expression of E-cadherin and β-catenin in cancer cells of metastatic lymph nodes in advanced gastric carcinoma.

目的 探讨进展期胃癌核因子-κB(nuclear factor-kappa B， NF-κB)蛋白的表达，上皮钙黏蛋白(E-cadherin， E-cad)及β-catenin在转移淋巴结内癌细胞中的再表达情况及其与临床病理因素的关系。

The expression of NF-κB protein is related to progression of the advanced gastric carcinoma. The re-expression of E-cadherin and β-catenin in cancer cells of metastatic lymph nodes from advanced gastric carcinoma existed, and which was closely correlated with tumor grade, may play an important role in the re-growth of cancer cells in metastatic foci.

NF-κB的表达与进展期胃癌的发展过程密切相关，E-cad及β-catenin在转移淋巴结中的再表达是进展胃癌发生的重要事件，二者协同发挥作用，并对癌细胞在转移灶中的聚集生长起重要作用，联合评价其功能具有更重要的临床意义。

The re-expression of α-and β-catenin in cancerous cells of metastatic lymph nodes from advanced gastric carcinoma is existent. and which correlates with tumor grade may play an important role in the re-growth of cancer cells in metastatic foci.

及β-catenin在转移淋巴结中的再表达是进展期胃癌发生的重要事件，二者协同发挥作用，并对癌细胞在转移灶中的聚集生长起重要作用，联合评价其功能具有更重要临床意义。

ResultsCharacteristic features at the presentation of AITL included generalized lymphadenopathy, fever, splenomegaly, and skin rashes with polyclonal hyper-gammaglobulinemia and other hematological abnormalities (such as Coombs-positive hemolytic anemia), which often involved the bone marrow and had well-described histologic features.The positive rate for CXCL13 was 93.3%.

结果：AITL主要表现为淋巴结肿大、发热、脾大和皮疹，伴有多克隆性高球蛋白血症和其他血液学异常如白细胞升高、Coombs试验阳性，常累及骨髓，具有特征性的病理组织学表现，免疫组织化学实验显示B-淋巴细胞趋化因子CXCL13阳性率为93.3%。

The concept of equivalent rotationally rigidity is offered and the formula of rotationally rigidity is obtained.

主要做了如下几个方面的工作：对伸臂位于顶部的单层框架—筒体模型进行分析，提出了等效转动约束的概念和转动约束刚度的表达式。

Male cats normally do not need aftercare with the exception of the night after the anesthetic.

男猫通常不需要善后除了晚上的麻醉。