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淋巴结

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Nodus lymphaticus metabasis is an important index for tumor stage and a prognosis.Lymphatic vessel formation plays an important role in pathologic state.

淋巴结转移是肿瘤分期的重要内容和预后指标,淋巴管生成对肿瘤淋巴结转移等具有十分重要的作用。

Objective To explore livin, MTA1 and the caspase3 protein expression, their correlation and clinical pathology in colon cancer Methods The expressions of livin, MTA1 and caspase3 protein in 88 cases of colon cancer were detected by immunohistochemistry stainingResults Livin, caspase3 protein and MTA1 positive expression rates in colon cancer tissues were more than those in tissues beside the cancer Furthermore there were obvious relevance between livin protein, MTA1 positive expression rate and degree of histodifferentiation and lymph node metabasis and between caspase3 protein positive expression rate and degree of histodifferentiation of colon cancer Caspase3 protein expression had prominent inverse correlation with the livin expressionConclusions ①Over expression of livin having inhibtion on colon cancer is one of important factors of colon carcinogenesis ②Caspase3 protein expression in colon cancer tissues is inhibited to less and has prominent inverse correlation with livin expression Accordingly, suppressing caspase3 protein activity is one of channels, by which livin promotes colon carcinogenesis ③MTA1 plays the important role in histodifferentiation degree and lymph node metastasis of colon cancer

采用免疫组织化学染色方法检测88例结肠癌组织中Livin,Caspase3 及MTA1的表达情况。结果(1)结肠癌组织中Livin的阳性表达率显著高于癌旁组织,且Livin的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。(2)结肠癌组织中Caspase3蛋白的阳性表达率显著高于癌旁组织,且Caspase3蛋白的表达与结肠癌的组织分化程度显著相关。(3)结肠癌组织中MTA1的阳性表达率显著高于癌旁组织,且MTA1的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。(4)Caspase3蛋白的表达又与Livin的表达呈显著负相关。结论(1)Livin在结肠癌组织中过表达,它可能是促进结肠癌发生的重要因素之一。(2)Caspase3蛋白在结肠癌组织中表达被抑制而降低,且与Livin的表达呈负相关。因此,抑制Caspase3蛋白的活性是Livin促进结肠癌发生的途径之一。(3)MTA1对结肠癌的组织分化及淋巴转移发挥重要作用。

The positive expression both of p14ARF and mtp53 protein in NSCLC tissues were significantly different from that in nonmal lung tissues and tissues adjacent to the cancer (P.01).The expression of p14ARF protein was correlated with pathological degree(P<0.01),but it was uncorrelated with pathological staging,lymphaden metabasis and vessel invasion(P>0.05).The expression of mtp53 protein was correlated with clinical pathology staging,pathological degree and vessel invasion(P<0.05 or P<0.01),but it was uncorrelated with lymphaden metabasis(P>0.05).(2) The coexpression of p14ARF and mtp53 was 36.7%,their consistency was 38.8%,but the expression of p14ARF protein were negatively correlated with the expression of mtp53 protein(r=-0.3553,P<0.001).Conclusion The results suggest that the decrease of p14ARF and the increase of mtp53 protein may play an important role in the genesis and development of NSCLC.

结果 (1)在正常肺组织、癌旁组织和NSCLC中p14ARF蛋白的阳性表达率分别为93.3%、83.3%、55.1%,mtp53蛋白的阳性表达率分别为6.7%、44.4%、79.6%;p14ARF蛋白和mtp53蛋白在NSCLC中的表达与正常肺组织和癌旁组织比较均有显著性差异(P<0.01);p14ARF蛋白表达与临床病理分期、有无淋巴结转移、有无脉管浸润无关(P>0.05),而与病理分化程度有关(P<0.01);mtp53蛋白表达与临床病理分期、病理分化程度(P<0.01)及有无脉管浸润(P<0.05)有关,而与有无淋巴结转移无关(P>0.05);(2)在NSCLC中,pl4ARF与mtp53蛋白共表达为36.7%,一致性为38.8%,二者表达呈负相关(r=-0.3553,P<0.001)。

Methods: 34 patients with early gastric carcinoma intraoperatively underwent sentinel lymph node biopsy with methylene blue.

目的:探讨前哨淋巴结活检技术在早期胃癌中的应用及前哨淋巴结微转移检测的临床意义。

The Main radiological findings of pulmonary tuberculosis in immunocompromised patients appear larger confluent consolidation, multiple small cavities within a given lesion, miliary tuberculosis, enlarged mediastinal lymph nodes, and extra chest enlarged lymph nodes.

3种免疫损害病变患者并发肺结核的主要CT及X线表现为大片融合病变、单一病变内的多发小空洞、粟粒型肺结核、纵隔淋巴结肿大及胸部以外的淋巴结肿大。

The expression of MGMT was correlated with the patients'age and lymph node metastasis,while the expression of Survivin was associated with lymph node metastasis only.

MGMT在乳腺癌中的表达与患者的年龄、淋巴结转移有关,而Survivin仅与淋巴结转移有关。

Objective To study the expression of CD44v6,COX-2 and MMP-2 in gastric carcinomas and there relationship to lymph node metastasis.Methods The expression of CD44v6,COX-2 and MMP-2 in gastric carcinomas were detected by immunohistochemical method,and their relationship with lymph node metastasis was analyzed.

目的 研究胃癌组织中CD44v6、COX-2、MMP-2的表达及其与胃癌淋巴结转移的关系方法用免疫组化方法检测胃癌组织中CD44v6、COX-2、MMP-2的表达情况,并分析其表达与胃癌淋巴结转移的关系。

And 0. 45. There were no notable differences of P-gp and MRP expression in lymph node metastasis negative and positive patients.

淋巴结转移组患者P—gp和MRP的表达分别为0.61和0.69,无淋巴结转移组患者分别为0.54和0.45,两者比较差异无统计学意义(P〉0.05)。

Nowadays, Ultrasound has been used widely to assess superficial and abdominal LNs, because it is convenient to operation, nonradioactive, cheap and accurate to diagnose diseases.

由于超声操作简便、无放射辐射、费用低、诊断准确率高,现已广泛用于诊断浅表淋巴结及腹部淋巴结病变。

The results demonstrated that nuclide lymph imaging possessed a certain guiding value in clearance of lymph nodes of early cervical cancer.

以上结果表明,前哨淋巴结核素显像对早期宫颈癌淋巴结清除术具有一定的指导价值。

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