淋巴瘤的

Methylation of CpG islands in the promoters induces gene silencing. The multiple tumor suppressor gene P16, located at chromosome 9p21, regulating normal proliferation of cells with a functional unit constituting of p16, cyclin D1 and pRb together. Methylation of P16 gene has been detected in several lymphocytic and plasmacytic malignancies such as lymphoma, acute lymphocytic leukemia and multiple myeloma and shows relationships with the pathogenesis of these diseases. Application of demethylation agents or arsenical to refresh the gene functions will be expected to be a new treatment for hemopoietic malignancies.

基因启动子区CpG岛甲基化常导致基因沉默。P16基因是一定位于9p21的多种肿瘤抑制基因，通过pl6INK4Acyclin D1-PRb通路维持机体细胞的有序增殖。P16基因甲基化在淋巴瘤、急性淋巴细胞性白血病、多发性骨髓瘤等多种淋巴细胞浆细胞肿瘤中被检测到，并与疾病的发生、发展存在一定关系，应用甲基化抑制因子或砷剂去甲基化治疗，恢复基因功能可望成为血液恶性肿瘤治疗的一种新手段。

To indolent lymphoma, Bexxar has higher remission rate than purely anti-CD20 monoclonal and the number of the patients with long-term catabasis after Bexxar are much more than thos number after chemotherapy.

对于惰性淋巴瘤，Bexxar比单纯抗CD20的抗体有较高的缓解率，并且用Bexxar治疗后取得了长期缓解的患者数目要远远大于化疗后的患者数目。

Prepare 131I-labbelled anti-CD20 monoclonal antibody using lodogen iodine labelling;(2)Measure the immunity activation of labbelled antibody by means of both cell combine analysis and LDH cytotoxicity detection kit;(3)Evaluate the injury rate of tumor exposed to 131I-chimeric anti-CD20 monoclonal antibody in vitro. The MTT method and the experiment of cell growth control are used;(4)Record the apotosis of Daudi cell using gelose electrophoresis;(5)Learn the inhibition effect of radioactive medication on the marrow. Radiohnmunoimages are taken on various intervals after injection of the labeled antibodies to the nude mice. The distribution of radioactive medication, I31l-labeled antibodies, in the marrow tissue indicates the inhibition effect. Here a B cell non-hodgkin lymphoma model in nude mice is established by us;(6)28-day observation are done in 3 groups of nude mice model.

(1) 用lodogen标记法制备131I-国产人鼠嵌合抗CD20单抗；(2)采用细胞结合分析法和乳酸脱氢酶法细胞杀伤性实验测定131I标记后国产人鼠嵌合抗CD20单抗与靶细胞的免疫活和利结合能力；(3) MTT法和细胞生长抑制实验测定131I-国产人鼠嵌合抗CD20单抗的体外杀瘤活性；(4)用琼脂糖凝胶电泳法研究131I-国产人鼠嵌合抗CD20单抗致Daudi细胞凋亡；(5)建立荷人B细胞淋巴瘤移植瘤裸鼠模型，应用γ计数法检测注射到荷瘤裸鼠体内的131I-国产人鼠嵌合抗CD20单抗的组织分布情况，明确其靶向性；(6)将荷瘤裸鼠分3组进行放射免疫治疗，分别为阴性对照组、131I-国产人鼠嵌合抗CD20单抗组、国产人鼠嵌合抗CD20单抗组。

We report two cases of nasal T/NK cell lymphoma with the unique feature of a crusted necrotic ulcer surrounded by erythematous infiltrative rim at midfacial region, clinically presented as so-called lethal midline granuloma.

我们提出两侧鼻部 T/NK细胞淋巴瘤，临床表现为所谓的致命性中线肉芽肿，病人在脸部的中央有一坏死结痂的溃疡，周围有红的浸润性病灶。

Helicobacter pylori is a spiral-shaped,Gram-negative bacterium,which is the main causes resulting in gastroduodenal ulcer and chronic reactiveness gastritis and has a close relationship with MALLT and gastric cancer.

幽门螺杆菌是一种存在于人类胃黏膜的G-的螺旋形细菌，是胃十二指肠溃疡、慢性活动性胃炎的主要病因，并与黏膜相关性淋巴组织淋巴瘤及胃癌的关系密切。

I think there are two important differential diagnoses for this case - seminoma and high grade diffuse large B cell lymphoma.

译：我认为本例有两个重要的鉴别诊断：单纯的精原细胞瘤和高度恶性的弥漫的大B细胞淋巴瘤。

Part II Regulation of gambogic acid on anti-apoptotic protein of Jurkat cells and Raji cellsTo study the Regulation of gambogic acid on anti-apoptotic protein of Jurkat cells and Raji cells.

第二部分藤黄酸对淋系肿瘤细胞系的细胞凋亡及抗凋亡蛋白的调控作用研究藤黄酸对人急性T淋巴细胞白血病细胞株Jurkat细胞和人Burkitt淋巴瘤细胞株Raji细胞的诱导凋亡及抗凋亡蛋白的调控作用。

In recent years,studies have revealed important roles of BAFF and its receptors in immune regulation of antibody isotype switching,germinal center maintenance,and T cell co-stimulation,that may provide new drugs in the future for the treatment of autoimmune disorders,lymphoma and B cell immunodeficiencies.

近几年来的研究表明，BAFF及其受体在抗体类型转换、生发中心维持、T细胞共刺激等方面发挥着重要的免疫调节作用，对自身免疫疾病、淋巴瘤和B细胞免疫缺陷的治疗具有潜在的应用前景。

Results: Small intestinal tumors with gastrointestinal bleeding had the following clinical characteristics:(1) Melena was more common;(2) Most of the patients were over 40 years old;(3) Benign tumors were more common;(4) Smooth muscle tumors is more common in the benign tumors which majouryly located injijunam.

结果 ：以消化道出血为主要症状的原发性小肠肿瘤的临床特点：(1)以便血为主；(2 )大多数在 4 0岁以上；(3)以良性肿瘤为多见；(4)良性肿瘤多为平滑肌肿瘤，主要位于空肠，而恶性肿瘤多位于回肠，以淋巴瘤和腺癌多见；(5 )消化道出血的时间和出血量与肿瘤的大小、性质无关。

Of lung cancer generally refers to the substance of the Ministry of lung cancer, often do not contain other pleural mesodermal origin of tumor, or malignant lymphoma, other malignant tumors such as carcinoid tumors, or transfer from other tumors.

肺癌一般指的是肺实质部的癌症，通常不包含其他肋膜起源的中胚层肿瘤，或恶性淋巴瘤、其他恶性肿瘤如类癌，或是转移自其他的肿瘤。

I will endeavour to find you some assistance.

我尽力帮你找人帮忙。

At first I only know bruck is the idol of American younglings, afterwards I returned back to Taiwan ,even in Beijing last year ,I saw her poster everywhere, I was so surprised at her charm.

起初我只晓得布鲁克雷德丝是美国少男少女崇拜的偶像，后来回台湾，甚至去年在北京，居然也四处看见她的海报，才惊讶她的魅力之大。