淋巴瘤

Results In those patients with marrow invasion , 4 cases in I phase（4.2%）,12 cases in II phase（12.6%）,36 cases in Ⅲ phase（37.9%）and 43 cases in Ⅳ phase(47.4%);small lymphocytic、diffuse cleaved cell、lymphoblastic lymphoma are main pathologic types;patients with mediastinal lymphadenectasis、splenomegaly and spleen violations are prone to catch bone marrow involvement;56 cases of anemia in patients with bone marrow involuement(58.9%), 42 patients with thrombocytopenia (44.2%),27 cases with leukopenia (28.4%),49 cases of patients leukocyte increased (51.6%),so,anemia is common;three were 30 cases with three items abnormal（31.6％）and 65 cases with one item abnormal at least (68.4%),the incidence of abnormal peripheral blood in leukocythemia patients were higher than that in patients with bone marrow infiltration,Particularly the patients with increased leukocyte or three items abnormalities were more common in leukemia; Abnormal cells in peripheral blood were observed in 66 cases (69.5%); chemotherapy efficiency reached 65.2% in the patients with bone marrow involuement,the median survival time was 11.5 months.

结果发生骨髓侵犯病例中I期4例（4.2%）， II期12例（12.6%），Ⅲ期36例（37.9%），Ⅳ期43例(47.4%)；病理类型以小淋巴细胞性，弥漫型裂细胞性（改为：弥漫性大B细胞型淋巴瘤）和淋巴母细胞性淋巴瘤多见；纵隔淋巴结肿大、脾脏肿大和脾受侵患者易发生骨髓侵犯；骨髓侵犯患者外周血中贫血56例(58.9%)，血小板减少42例(44.2%)，白细胞减少27例(28.4%)，白细胞增高49例(51.6%)，以贫血多见；三项均异常30例(31.6%)，至少一项不正常65例(68.4%)，淋巴瘤细胞白血病患者外周血象异常发生率高于骨髓浸润患者，尤其是白细胞增高或三项均异常者更常见于白血病；66例(69.5%)外周血分类中发现异常细胞；骨髓侵犯化疗有效率65.2%，中位生存期11.5个月。

Results In those patients with marrow invasion , 4 cases in I phase（4.2%）,12 cases in II phase（12.6%）,36 cases in Ⅲ phase（37.9%）and 43 cases in Ⅳ phase(47.4%);small lymphocytic、diffuse cleaved cell、lymphoblastic lymphoma are main pathologic types;patients with mediastinal lymphadenectasis、splenomegaly and spleen violations are prone to catch bone marrow involvement;56 cases of anemia in patients with bone marrow involuement(58.9%)恶性淋巴瘤症状, 42 patients with thrombocytopenia (44.2%),27 cases with leukopenia (28.4%),49 cases of patients leukocyte increased (51.6%),so,anemia is common;three were 30 cases with three items abnormal（31.6％）and 65 cases with one item abnormal at least (68.4%),the incidence of abnormal peripheral blood in leukocythemia patients were higher than that in patients with bone marrow infiltration,Particularly the patients with increased leukocyte or three items abnormalities were more common in leukemia; Abnormal cells in peripheral blood were observed in 66 cases (69.5%); chemotherapy efficiency reached 65.2% in the patients with bone marrow involuement,the median survival time was 11.5 months.

结果发生骨髓侵犯病例中I期4例（4.2%）， II期12例（12.6%），Ⅲ期36例（37.9%）恶性淋巴瘤分期，Ⅳ期43例(47.4%)；病理类型以小淋巴细胞性，弥漫型裂细胞性（改为：弥漫性大B细胞型淋巴瘤）和淋巴母细胞性淋巴瘤多见；纵隔淋巴结肿大、脾脏肿大和脾受侵患者易发生骨髓侵犯；骨髓侵犯患者外周血中贫血56例(58.9%)，血小板减少42例(44.2%)，白细胞减少27例(28.4%)，白细胞增高49例(51.6%)，以贫血多见；三项均异常30例(31.6%)，至少一项不正常65例(68.4%)，淋巴瘤细胞白血病患者外周血象异常发生率高于骨髓浸润患者，尤其是白细胞增高或三项均异常者更常见于白血病；66例(69.5%)外周血分类中发现异常细胞；骨髓侵犯化疗有效率65.2%，中位生存期11.5个月。

Methods Tissue arrayer was used to create a 252-dot tissue microarray, consisting of 84 cases of malignant lymphomas arising in esophagus, stomach, intestines, thyroid, saliva gland , orbital cavity and lung, Seven cases of diffuse large B cell lymphomas,9 adenocarcinomas, 1 neuroendocrine tumor,1 squamous carcinoma, 6 T-cell lymphomas and 18 reactive lymphoid nodes were also included as control in the microarray.

建立包含84例MALT型淋巴瘤、7例弥漫性大B细胞淋巴瘤、9例腺癌、1例神经内分泌肿瘤、1例鳞癌、6例T细胞性非何杰金淋巴瘤和18例正常淋巴结共252点阵的组织芯片，应用免疫组织化学检测Ki-67、TopoⅡα、p53、Bcl-2、Bax、C-myc和Bcl-10在MALT型淋巴瘤中的表达情况。

ALCL was not uncommon in children. The differential diagnoses included malgnant histiocytosis, T zone or pleomorphic T-cell lymphoma, Hodgkins lymphoma, mycosis fungoides, and metastatic carcinoma.

小儿间变性大细胞性淋巴瘤并不少见，需与恶性组织细胞增生症、T区或多形T淋巴瘤、霍奇金淋巴瘤、蕈样霉菌病和转移性癌等鉴别。

alcl was not uncommon in children. the differential diagnoses included malgnant histiocytosis, t zone or pleomorphic t-cell lymphoma, hodgkins lymphoma, mycosis fungoides, and metastatic carcinoma. immunohistochemical study cd30, cd15, lca and ema were very helpful for diagnosis and differential diagnosis.

小儿间变性大细胞性淋巴瘤并不少见，需与恶性组织细胞增生症、t区或多形t淋巴瘤、霍奇金淋巴瘤、蕈样霉菌病和转移性癌等鉴别。cd30、cd15、lca和ema免疫酶标检查对诊断及鉴别诊断十分有用。

In this topic we detected the expression level of SDF-1,CXCR4,VEGF of the above two malignant hematological tumors as well as their relations to the tumor cell"s characters of drug resistance and infiltration etc, and then elucidated the change of the microenviroment" on the occurrence and development of hematologic tumor. This topic may provide some theoretical and clinical proofs for finding out some new therapeusis to the above two malignant hematological tumors.

本课题旨在通过研究急性白血病和恶性淋巴瘤患者SDF-1、CXCR4、VEGF的表达水平及其与肿瘤细胞迁移、耐药、浸润的关系，阐明骨髓造血微环境和恶性淋巴瘤局部病变微环境的改变在上述血液肿瘤发生发展中的作用及其与血管新生的联系，为从新的角度探索白血病、淋巴瘤的治疗方法提供理论及临床依据。

Objective We sought to investigate the clinical features as well as characteristics of the immunological forms with respect to the idiopathically head-neck non-Hodgkin's lymphoma.

恶性淋巴瘤是来自淋巴系统及网状内皮系统的非上皮性恶性肿瘤。非霍奇金淋巴瘤常发生在淋巴结内，而首发于淋巴结外的恶性淋巴瘤仅占全身恶性淋巴瘤的10%~15%，易于广泛播散。

Three cases of advanced NHL associated with lymphomatous leptomeningitis were reported with a review of the literature.Two of the patients were poorly differenti- ated lymphocytic lymphoma,diffuse type,and the other Burkitt's lymphoma.

本文报告3例淋巴瘤性脑膜炎，并复习文献讨论淋巴瘤脑膜炎的诊断、治疗和预防。3例患者均为晚期非何杰金氏淋巴瘤。1例为低分化淋巴细胞淋巴瘤弥漫型，1例为 Burkitt's 淋巴瘤。

Results Of 62 cases of PMLGI, 6 cases were low grade malignant B-cell lymphoma of MALT type, 14 cases high grade malignant B-cell lymphoma of MALT type with a low grade malignant component, 1 case lymphomatous polyposes, 2 cases Butkitt-like lymphoma, 38 cases B-cell large cell lymphoma and 1 case intestinal T-cell lymphoma.

结果：62例PMLGI中，低度恶性B细胞粘膜相关组织型淋巴瘤6例，高度恶性B细胞粘膜相关组织型淋巴瘤伴低恶成分14例，淋巴瘤性息肉病1例，Burkitt样淋巴瘤2例，B大细胞淋巴瘤38例，肠道T细胞淋巴瘤1例。

This experiment try to investigate the expressions of Epstein-Barr virus latent membrane protein 1(LMP-1),nuclear factor κ gene bindingand the apoptotic index in nasal NK/T cell lymphoma,and probe into the correlation of LMP-1 with NF-κB,AI,analyze their roles in the occurrence and development of nasal NK/T cell lymphomaMethods:From 1999 to 2004 ,26 cases of nasal NK/T cell lymphoma and 10 cases of benign lymph follicle hyperplasia were selected from Department of Pathology in Hospital of Shangdong province .

目的：EB病毒Epstein-Barr virus在鼻NK/T细胞淋巴瘤(nasal NK/T cell lymphoma)的瘤细胞的检出率较高，但其在淋巴瘤发生发展中的确切作用尚不清楚，本研究通过检测鼻腔NK/T细胞淋巴瘤中EB病毒感染潜伏膜蛋白(latent membrane protein-1，LMP-1)与细胞因子κB(nuclear factor κ gene binding，NF-κB)的表达及其细胞凋亡指数(apoptotic index，AI)，比较三者间相互关系，分析EB病毒在鼻NK/T细胞淋巴瘤发生发展中的致瘤机制。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。