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The Expression of P16, CyclinD1 and Cdk4 in Salivary Gland Carcinoma and Their Significance

论文标题:P16,cyclinD1和cdk4在涎腺癌组织中的表达及意义

The abnormal condition of telomere is involved in salivary tumor transformation.

端粒的异常状态参与涎腺肿瘤的发生。

Objective: To investigate the expression of nuclear factor-kappaB in the polymorphic adenoma of salivary glands.

目的:研究在涎腺多形性腺瘤中表达及意义。

Grens syndrome,also called sicca syndrome, is a chronic and inflammatory autoimmune disorder characterized by the progressive lymphocytic and plasma cell infiltration of salivary and lacrimal glands, which eventually results in xerostomia and xerophthalmia.

grens syndrome, SS),也称干燥综合征,是一种慢性炎症性自身免疫性疾病,病理特征为大量淋巴细胞和浆细胞进行性浸润涎腺和泪腺。临床表现为口干、眼干,根据是否伴有全身结缔组织病,SS可分为原发和继发两个类型。

A portion of ductal cells and individual serous acinic cells of the minor salivary gland also expressed Fas not only in membranous but also in cytoplasmic pattern.

结果发现,在正常鼻咽粘膜表面及隐窝的假复层纤毛柱状上皮细胞胞膜、部分小涎腺的导管上皮和个别浆液性腺泡上皮细胞的胞膜和胞浆Fas阳性表达;鳞状化生上皮的表层细胞胞膜有Fas表达,但基底细胞未见Fas表达;浸润的淋巴细胞也不表达Fas.45.9%(17/37)的鼻咽非角化性癌Fas阳性,但只有不足10%的癌细胞胞膜微弱表达Fas。

An expression vector for one isoform of the mbC α1 subunit cDNA was constructed using the human cytomegalovirus promoter to direct expression and this expression vector was used in a novel transfection assay of primary cultures of bovine adrenal chromaffin cells.

为表达具有生物活性的钙离子通道,将mbC的一个异构体的蛋白编码区插入到由人的涎腺病毒启动子控制表达的质粒中。这个表达质粒

Methods 147cases of common tumor of salivary gland, confirmed by Needle aspiration cytodiagnosis were retrospectively analyzed and compared with findings from histopathology.

回顾性分析147例针吸细胞学诊断的涎腺常见肿瘤,并与病理组织学进行对照。

Diagnostic coincidence rate and diagnostic accuracy of needle aspiration cytodiagnosis was 97.83% and 88.04%; respectively for salivary benign tumor as well as 96.36% and 78.18% respectively for salivary malignancies.

结果 针吸细胞学诊断涎腺肿瘤的总符合率为91.84%,其中良性肿瘤定性诊断符合率为97.83%,准确率88.04%;恶性肿瘤定性诊断符合率为96.36%,准确率为78.18%。

Results Total diagnostic coincidence rate was 91.84%. Diagnostic coincidence rate and diagnostic accuracy of needle aspiration cytodiagnosis was 97.83% and 88.04%; respectively for salivary benign tumor as well as 96.36% and 78.18% respectively for salivary malignancies.

结果 针吸细胞学诊断涎腺肿瘤的总符合率为91.84%,其中良性肿瘤定性诊断符合率为97.83%,准确率88.04%;恶性肿瘤定性诊断符合率为96.36%,准确率为78.18%。

Materials and Methods 15 cases included 8 salivary gland mixed tumors, 2 capillary hemangiomas, 3 squamous cell carcinoma and 2 mucous epidermoid cyst.

资料与方法本组15例中涎腺混合瘤8例,海绵状血管瘤2例,鳞状细胞癌3例,黏液表皮样囊肿2例。

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